A Note on Screening Regression Equations

Consider developing a regression model in a context where substantive theory is weak. To focus on an extreme case, suppose that in fact there is no relationship between the dependent variable and the explanatory variables. Even so, if there are many explanatory variables, the R ² will be high. If explanatory variables with small t statistics are dropped and the equation refitted, the R ² will stay high and the overall F will become highly significant. This is demonstrated by simulation and by asymptotic calculation.     

Efficient network meta-analysis: A confidence distribution approach

Network meta-analysis synthesizes several studies of multiple treatment comparisons to simultaneously provide inference for all treatments in the network. It can often strengthen inference on pairwise comparisons by borrowing evidence from other comparisons in the network. Current network meta-analysis approaches are derived from either conventional pairwise meta-analysis or hierarchical Bayesian methods. This paper introduces a new approach for network meta-analysis by combining confidence distributions (CDs). Instead of combining point estimators from individual studies in the conventional approach, the new approach combines CDs, which contain richer information than point estimators, and thus achieves greater efficiency in its inference. The proposed CD approach can efficiently integrate all studies in the network and provide inference for all treatments, even when individual studies contain only comparisons of subsets of the treatments. Through numerical studies with real and simulated data sets, the proposed approach is shown to outperform or at least equal the traditional pairwise meta-analysis and a commonly used Bayesian hierarchical model. Although the Bayesian approach may yield comparable results with a suitably chosen prior, it is highly sensitive to the choice of priors (especially for the between-trial covariance structure), which is often subjective. The CD approach is a general frequentist approach and is prior-free. Moreover, it can always provide a proper inference for all the treatment effects regardless of the between-trial covariance structure.     

On the conservative simultaneous confidence procedures for multiple comparisons among mean vectors

In this paper, conservative simultaneous confidence intervals for multiple comparisons among mean vectors in multivariate normal distributions are considered. Some properties of the multivariate Tukey–Kramer procedure for pairwise comparisons and the conservative simultaneous confidence procedure for comparisons with a control are presented. Particularly, the upper bound for the conservativeness of the simultaneous confidence procedure for comparisons with a control is obtained. Finally, numerical results by Monte Carlo simulations and an example to illustrate the procedure are given.     

Bayesian latent variable models for clustered mixed outcomes

A general framework is proposed for modelling clustered mixed outcomes. A mixture of generalized linear models is used to describe the joint distribution of a set of underlying variables, and an arbitrary function relates the underlying variables to be observed outcomes. The model accommodates multilevel data structures, general covariate effects and distinct link functions and error distributions for each underlying variable. Within the framework proposed, novel models are developed for clustered multiple binary, unordered categorical and joint discrete and continuous outcomes. A Markov chain Monte Carlo sampling algorithm is described for estimating the posterior distributions of the parameters and latent variables. Because of the flexibility of the modelling framework and estimation procedure, extensions to ordered categorical outcomes and more complex data structures are straightforward. The methods are illustrated by using data from a reproductive toxicity study.     

Latent class models for longitudinal studies of the elderly with data missing at random

The elderly population in the USA is expected to double in size by the year 2025, making longitudinal health studies of this population of increasing importance. The degree of loss to follow-up in studies of the elderly, which is often because elderly people cannot remain in the study, enter a nursing home or die, make longitudinal studies of this population problematic. We propose a latent class model for analysing multiple longitudinal binary health outcomes with multiple-cause non-response when the data are missing at random and a non-likelihood-based analysis is performed. We extend the estimating equations approach of Robins and co-workers to latent class models by reweighting the multiple binary longitudinal outcomes by the inverse probability of being observed. This results in consistent parameter estimates when the probability of non-response depends on observed outcomes and covariates (missing at random) assuming that the model for non-response is correctly specified. We extend the non-response model so that institutionalization, death and missingness due to failure to locate, refusal or incomplete data each have their own set of non-response probabilities. Robust variance estimates are derived which account for the use of a possibly misspecified covariance matrix, estimation of missing data weights and estimation of latent class measurement parameters. This approach is then applied to a study of lower body function among a subsample of the elderly participating in the 6-year Longitudinal Study of Aging.     

Expected utility within a generalized concept of probability — a comprehensive framework for decision making under ambiguity

It has often been complained that the standard framework of decision theory is insufficient. In most applications, neither the maximin paradigm (relving on complete ignorance on the states of natures) nor the classical Bayesian paradigm (assuming perfect probabilistic information on the states of nature) reflect the situation under consideration adequately. Typically one possesses some, but incomplete, knowledge on the stochastic behaviour of the states of nature. In this paper first steps towards a comprehensive framework for decision making under such complex uncertainty will be provided. Common expected utility theory will be extended to interval probability, a generalized probabilistic setting which has the power to express incomplete stochastic knowledge and to take the extent of ambiguity (non-stochastic uncertainty) into account. Since two-monotone and totally monotone capacities are special cases of general interval probatility, wher Choquet integral and interval-valued expectation correspond to one another, the results also show, as a welcome by-product, how to deal efficiently with Choquet Expected Utility and how to perform a neat decision analysis in the case of belief functions. Received: March 2000; revised version: July 2001     

Assessing Profitability of a Newsboy-Type Product with Normally Distributed Demand Based on Multiple Samples

This article develops a new index “Achievable Capacity Index,” I _A , which can accurately measure the profitability of newsboy-type product with normally distributed demand. An unbiased and effective estimator of I _A is derived to estimate actual I _A as the parameters of distribution are unknown. Practically, the market information regarding demand is obtained from multiple samples rather than single sample. Therefore, we estimate and test I _A based on multiple samples. A hypothesis testing for examining whether the profitability meets designated requirement is presented. Critical values of the test are calculated to determine the evaluation results. Finally, a real case on the sales of donuts is presented to illustrate the applicability of our approach.     

Small-Area Estimation of Economic Statistics

A ratio-correlation (multiple regression) approach for estimating key economic statistics for small areas is proposed and compared with several synthetic estimation methods using various measures of performance. Using published data that are easily accessible, the methods provide a means of estimating statistics not currently published with a reasonable amount of error.     

SAMPLE SIZE DETERMINATION FOR MULTIPLE MANY-ONE AND PAIRWISE COMPARISONS OF PROPORTIONS USING THE ARCSIN TRANSFORMATION

Our paper provides sample size formulas for multiple comparisons of k treatments with a control as well as with pairwise comparisons of k treatments when observing proportions. The test statistics we regard use the arcsin transformation of the proportions. We determine sample sizes with preassigned all-pairs, any-pair and per-pair power considering the control either of the comparisonwise or of the familywise type I error rate.