Tests of hypotheses based on ranks in the general linear model

A unified approach is developed for testing hypotheses in the general linear model based on the ranks of the residuals. It complements the nonparametric estimation procedures recently reported in the literature. The testing and estimation procedures together provide a robust alternative to least squares. The methods are similar in spirit to least squares so that results are simple to interpret. Hypotheses concerning a subset of specified parameters can be tested, while the remaining parameters are treated as nuisance parameters. Asymptotically, the test statistic is shown to have a chi-square distribution under the null hypothesis. This result is then extended to cover a sequence of contiguous alternatives from which the Pitman efficacy is derived. The general application of the test requires the consistent estimation of a functional of the underlying distribution and one such estimate is furnished.     

New difference-based estimator of parameters in semiparametric regression models

The paper introduces a new difference-based Liu estimator β?_Ldiff=([Xtilde]′[Xtilde]+I)^?1([Xtilde]′[ytilde]+η β?_diff) of the regression parameters β in the semiparametric regression model, y=Xβ+f+?. Difference-based estimator, β?_diff=([Xtilde]′[Xtilde])^?1[Xtilde]′[ytilde] and difference-based Liu estimator are analysed and compared with respect to mean-squared error (mse) criterion. Finally, the performance of the new estimator is evaluated for a real data set. Monte Carlo simulation is given to show the improvement in the scalar mse of the estimator.     

Case–control genome-wide joint association study using semiparametric empirical model and approximate Bayes factor

We propose a semiparametric approach for the analysis of case–control genome-wide association study. Parametric components are used to model both the conditional distribution of the case status given the covariates and the distribution of genotype counts, whereas the distribution of the covariates are modelled nonparametrically. This yields a direct and joint modelling of the case status, covariates and genotype counts, and gives a better understanding of the disease mechanism and results in more reliable conclusions. Side information, such as the disease prevalence, can be conveniently incorporated into the model by an empirical likelihood approach and leads to more efficient estimates and a powerful test in the detection of disease-associated SNPs. Profiling is used to eliminate a nuisance nonparametric component, and the resulting profile empirical likelihood estimates are shown to be consistent and asymptotically normal. For the hypothesis test on disease association, we apply the approximate Bayes factor (ABF) which is computationally simple and most desirable in genome-wide association studies where hundreds of thousands to a million genetic markers are tested. We treat the approximate Bayes factor as a hybrid Bayes factor which replaces the full data by the maximum likelihood estimates of the parameters of interest in the full model and derive it under a general setting. The deviation from Hardy–Weinberg Equilibrium (HWE) is also taken into account and the ABF for HWE using cases is shown to provide evidence of association between a disease and a genetic marker. Simulation studies and an application are further provided to illustrate the utility of the proposed methodology.     

General treatment of goodness-of-fit tests based on Kullback–Leibler information

This paper introduces a general goodness-of-fit test based on the estimated Kullback–Leibler information. The test uses the Vasicek entropy estimate. Two special cases of the test for location–scale and shape families are discussed. The results are used to introduce goodness-of-fit tests for the uniform, Laplace, Weibull and beta distributions. The critical values and powers for some alternatives are obtained by simulation.     

Accent on Teaching Materials

Estimation of covariance components in the multivariate random-effect model with nested covariance structure is discussed. There are two covariance matrices to be estimated, namely, the between-group and the within-group covariance matrices. These two covariance matrices are most often estimated by forming a multivariate analysis of variance and equating mean square matrices to their expectations. Such a procedure involves taking the difference between the between-group mean square and the within-group mean square matrices, and often produces an estimated between-group covariance matrix that is not nonnegative definite. We present estimators of the two covariance matrices that are always proper covariance matrices. The estimators are the restricted maximum likelihood estimators if the random effects are normally distributed. The estimation procedure is extended to more complicated models, including the twofold nested and the mixed-effect models. A numerical example is presented to illustrate the use of the estimation procedure.     

Bayesian Binomial Regression: Predicting Survival at a Trauma Center

Standard methods for analyzing binomial regression data rely on asymptotic inferences. Bayesian methods can be performed using simple computations, and they apply for any sample size. We provide a relatively complete discussion of Bayesian inferences for binomial regression with emphasis on inferences for the probability of “success.” Furthermore, we illustrate diagnostic tools, perform model selection among nonnested models, and examine the sensitivity of the Bayesian methods.     

Simulating from irregular data: Kernel Carlo Simulation

In this paper, we address the problem of simulating from a data-generating process for which the observed data do not follow a regular probability distribution. One existing method for doing this is bootstrapping, but it is incapable of interpolating between observed data. For univariate or bivariate data, in which a mixture structure can easily be identified, we could instead simulate from a Gaussian mixture model. In general, though, we would have the problem of identifying and estimating the mixture model. Instead of these, we introduce a non-parametric method for simulating datasets like this: Kernel Carlo Simulation. Our algorithm begins by using kernel density estimation to build a target probability distribution. Then, an envelope function that is guaranteed to be higher than the target distribution is created. We then use simple accept–reject sampling. Our approach is more flexible than others, can simulate intelligently across gaps in the data, and requires no subjective modelling decisions. With several univariate and multivariate examples, we show that our method returns simulated datasets that, compared with the observed data, retain the covariance structures and have distributional characteristics that are remarkably similar.     

Rethinking Print Periodicals Holdings Retention Policy in Small Academic Libraries

Abstract

Collection development policies in small academic libraries may lack a formal policy statement about print periodical holdings retention. However, there is a need for a distinct policy about print periodicals holdings and their retention. Periodicals collections at academic libraries have been greatly affected by publishers’ decisions to discontinue print journal formats and move to online-only electronic versions. The move from one format to another produces challenges to the retention of an effective print periodicals collection. Given these continuous changes in publication format, it is necessary for academic libraries to rethink their print periodicals holdings retention. This article will present a literature review on and case study of periodicals collection management and explore strategies for developing holdings policies and guidelines for retention. It will argue that collection development policies ought to include a separate policy for the print periodicals collection and that unlike their reputation for being time-consuming and inflexible, periodical retention policies can improve flexibility and guide in decision making, helping to preserve core titles and acquire new titles that support academic programs and the work of the college community.     

Accuracy Analysis of the Percentile Method for Estimating Non Normal Manufacturing Quality

We consider asymmetric kernel estimates based on grouped data. We propose an iterated scheme for constructing such an estimator and apply an iterated smoothed bootstrap approach for bandwidth selection. We compare our approach with competing methods in estimating actuarial loss models using both simulations and data studies. The simulation results show that with this new method, the estimated density from grouped data matches the true density more closely than with competing approaches.     

An Adaptive Test for the Two-Sample Location Problem Based on U-Statistics

For the two-sample location problem with continuous data we consider a general class of tests, all members of it are based on U-statistics. The asymptotic efficacies are investigated in detail. We construct an adaptive test where all statistics involved are suitably chosen U-statistics. It is shown that the proposed adaptive test has good asymptotic and finite sample power properties.