Model‐free causal inference of binary experimental data

For binary experimental data, we discuss randomization‐based inferential procedures that do not need to invoke any modeling assumptions. In addition to the classical method of moments, we also introduce model‐free likelihood and Bayesian methods based solely on the physical randomization without any hypothetical super population assumptions about the potential outcomes. These estimators have some properties superior to moment‐based ones such as only giving estimates in regions of feasible support. Due to the lack of identification of the causal model, we also propose a sensitivity analysis approach that allows for the characterization of the impact of the association between the potential outcomes on statistical inference.     

Bayesian quantile regression and variable selection for partial linear single-index model: Using free knot spline

Partial linear single-index model (PLSIM) has both the flexibility of nonparametric treatment and interpretability of linear term, yet existing literatures about it mainly focused on mean regression, and quantile regression analysis is scarce. Based on free knot spline approximation, we apply asymmetric Laplace distribution to implement Bayesian quantile regression, and perform variable selection in linear term and index vector via binary indicators. Our approach is exempt from regularity conditions in frequentist method, and could execute variable selection and quantile regression under mutual posterior correction, which is also the first work to implement them jointly for PLSIM in fully Bayesian framework. The numerical simulation manifests the superiority of our approach to previous methods, which embodied in better efficiency of variable selection, index vector estimates and link function approximation with different error distributions. For illustration of its application, we build a power consumption model of A₂/O process in wastewater treatment and emphatically analyze the impact of water quality factors.     

Welfare gains of the poor: An endogenous Bayesian approach with spatial random effects

We introduce a Bayesian instrumental variable procedure with spatial random effects that handles endogeneity, and spatial dependence with unobserved heterogeneity. We find through a limited Monte Carlo experiment that our proposal works well in terms of point estimates and prediction. We apply our method to analyze the welfare effects generated by a process of electricity tariff unification on the poorest households. In particular, we deduce an Equivalent Variation measure where there is a budget constraint for a two-tiered pricing scheme, and find that 10% of the poorest municipalities attained welfare gains above 2% of their initial income.     

基于带跳时变系数模型的PPI与CPI相关性研究

2008年以来,我国PPI与CPI走势出现了多次背离与分化,从整体上看,两者相关性很弱。但从动态视角来看,由于相关关系可能会因时而变,整体相关性有可能被关系本身的方向和强弱变化所削弱甚至掩盖。为准确反映两者相关性的动态变化,本文放宽时变系数函数的光滑性假设,提出了带跳时变系数模型,并给出一种非参数三步估计方法：首先,估计系数函数中跳点的位置和个数;然后,基于估计的跳点和Bootstrap方法选择的窗宽给出系数函数的最终估计;最后,利用蒙特卡洛模拟评价本文提出的非参数估计和窗宽选择方法的有限样本性质。通过对2008年1月至2017年12月我国PPI和CPI月度同比数据的实证分析,我们发现该模型能较好地刻画PPI与CPI相关性的时变和带跳特征,进而也验证了该模型的应用价值。     

A generalized Bayesian nonlinear mixed‐effects regression model for zero‐inflated longitudinal count data in tuberculosis trials

In this paper, we investigate Bayesian generalized nonlinear mixed‐effects (NLME) regression models for zero‐inflated longitudinal count data. The methodology is motivated by and applied to colony forming unit (CFU) counts in extended bactericidal activity tuberculosis (TB) trials. Furthermore, for model comparisons, we present a generalized method for calculating the marginal likelihoods required to determine Bayes factors. A simulation study shows that the proposed zero‐inflated negative binomial regression model has good accuracy, precision, and credibility interval coverage. In contrast, conventional normal NLME regression models applied to log‐transformed count data, which handle zero counts as left censored values, may yield credibility intervals that undercover the true bactericidal activity of anti‐TB drugs. We therefore recommend that zero‐inflated NLME regression models should be fitted to CFU count on the original scale, as an alternative to conventional normal NLME regression models on the logarithmic scale.     

Treatment effect quantification for time‐to‐event endpoints–Estimands,analysis strategies,and beyond

A draft addendum to ICH E9 has been released for public consultation in August 2017. The addendum focuses on two topics particularly relevant for randomized confirmatory clinical trials: estimands and sensitivity analyses. The need to amend ICH E9 grew out of the realization of a lack of alignment between the objectives of a clinical trial stated in the protocol and the accompanying quantification of the “treatment effect” reported in a regulatory submission. We embed time‐to‐event endpoints in the estimand framework and discuss how the four estimand attributes described in the addendum apply to time‐to‐event endpoints. We point out that if the proportional hazards assumption is not met, the estimand targeted by the most prevalent methods used to analyze time‐to‐event endpoints, logrank test, and Cox regression depends on the censoring distribution. We discuss for a large randomized clinical trial how the analyses for the primary and secondary endpoints as well as the sensitivity analyses actually performed in the trial can be seen in the context of the addendum. To the best of our knowledge, this is the first attempt to do so for a trial with a time‐to‐event endpoint. Questions that remain open with the addendum for time‐to‐event endpoints and beyond are formulated, and recommendations for planning of future trials are given. We hope that this will provide a contribution to developing a common framework based on the final version of the addendum that can be applied to design, protocols, statistical analysis plans, and clinical study reports in the future.     

Focused estimation for noisy and small data sets: a Bayesian minimum expected loss estimator approach

Central to many inferential situations is the estimation of rational functions of parameters. The mainstream in statistics and econometrics estimates these quantities based on the plug‐in approach without consideration of the main objective of the inferential situation. We propose the Bayesian Minimum Expected Loss (MELO) approach focusing explicitly on the function of interest, and calculating its frequentist variability. Asymptotic properties of the MELO estimator are similar to the plug‐in approach. Nevertheless, simulation exercises show that our proposal is better in situations characterised by small sample sizes and/or noisy data sets. In addition, we observe in the applications that our approach gives lower standard errors than frequently used alternatives when data sets are not very informative.     

Posterior consistency in frailty models and simulation studies to test the presence of random effects

The estimation of random effects in frailty models is an important problem in survival analysis. Testing for the presence of random effects can be essential to improving model efficiency. Posterior consistency in dispersion parameters and coefficients of the frailty model was demonstrated in theory and simulations using the posterior induced by Cox’s partial likelihood and simple priors. We also conducted simulation studies to test for the presence of random effects; the proposed method performed well in several simulations. Data analysis was also conducted. The proposed method is easily tractable and can be used to develop various methods for Bayesian inference in frailty models.     

Experimental designs in management and leadership research: Strengths,limitations, and recommendations for improving publishability

Despite the renewed interest in the use of experimental designs in the fields of leadership and management over the past few decades, these designs are still relatively underutilized. Although there are several potential reasons for this, chief among them is misunderstanding the value of these designs. The purpose of this article is to review the role of laboratory, field, and quasi-experimental designs in management and leadership research. We first discuss the primary goals of experimental studies. Next, we examine the characteristics of experimental designs and how to distinguish laboratory, field, and quasi-experiments from one another and from non-experimental studies. Following these discussions, we provide examples of each type of experimental design and discuss their relative strengths and limitations. Finally, we discuss steps that researchers can take to increase the probability of having articles reporting experiments accepted by leadership and management journals.     

The analysis of multiple ties in longitudinal egocentric network data: A case study on bidirectional relationships between trust and drug use

We extend multi-level models to examine single egocentric network ties to the joint analysis of paired dynamic ties. Two analytic challenges are addressed. First, inference needs to account for multiple layers of nesting: ties are nested within pairs, pairs are nested within time points, and time points are nested within egos. Second, the focus is on the relationship between two dynamic ties; specification of outcome and predictor may be difficult. Instead, we treat both ties as outcomes. Our approach is used to analyze trust and reported drug use between egos and alters over time in a Bayesian framework.