Simulated annealing for the bounds of Kendall's τ and Spearman's ρ

It has long been known that, for many joint distributions, Kendall's τ and Spearman's ρ have different values, as they measure different aspects of the dependence structure. Although the classical inequalities between Kendall's τ and Spearman's ρ for pairs of random variables are given, the joint distributions which can attain the bounds between Kendall's τ and Spearman's ρ are difficult to find. We use the simulated annealing method to find the bounds for ρ in terms of τ and its corresponding joint distribution which can attain those bounds. Furthermore, using this same method, we find the improved bounds between τ and ρ, which is different from that given by Durbin and Stuart.     

Optimal design and maintenance of a repairable multi-state system with standby components

The configuration of a repairable system directly influences its performance measures, such as mean time between failures and steady state availability. Additionally, maintenance strategies such as corrective, preventive, and condition-based can affect the performance of the system. The objective of this work is to investigate the trade-offs between the configuration of a repairable multi-state system with binary components and its maintenance strategy. The corresponding stochastic process for the proposed model is formulated using the continuous-time Markov process and important performance measures of such a multi-state system are derived. An optimization model is introduced for the cost-effective design of this repairable multi-state system. The results are demonstrated using a numerical example for a power generation system.     

Optimal quantization applied to sliced inverse regression

In this paper we consider a semiparametric regression model involving a d-dimensional quantitative explanatory variable X and including a dimension reduction of X via an index β′X. In this model, the main goal is to estimate the Euclidean parameter β and to predict the real response variable Y conditionally to X. Our approach is based on sliced inverse regression (SIR) method and optimal quantization in L^p-norm. We obtain the convergence of the proposed estimators of β and of the conditional distribution. Simulation studies show the good numerical behavior of the proposed estimators for finite sample size.     

Efficient circular neighbour designs for spatial interference model

We consider circular block designs for field-trials when there are two-sided spatial interference between neighbouring plots of the same blocks. The parameter of interest is total effects that is the sum of direct effect of treatment and neighbour effects, which correspond to the use of a single treatment in the whole field. We determine universally optimal approximate designs. When the number of blocks may be large, we propose efficient exact designs generated by a single sequence of treatment. We also give efficiency factors of the usual binary block neighbour balanced designs which can be used when the number of blocks is small.     

Optimal designs for response functions with a downturn

In many toxicological assays, interactions between primary and secondary effects may cause a downturn in mean responses at high doses. In this situation, the typical monotonicity assumption is invalid and may be quite misleading. Prior literature addresses the analysis of response functions with a downturn, but so far as we know, this paper initiates the study of experimental design for this situation. A growth model is combined with a death model to allow for the downturn in mean doses. Several different objective functions are studied. When the number of treatments equals the number of parameters, Fisher information is found to be independent of the model of the treatment means and on the magnitudes of the treatments. In general, A- and D_A-optimal weights for estimating adjacent mean differences are found analytically for a simple model and numerically for a biologically motivated model. Results on c-optimality are also obtained for estimating the peak dose and the EC₅₀ (the treatment with response half way between the control and the peak response on the increasing portion of the response function). Finally, when interest lies only in the increasing portion of the response function, we propose composite D-optimal designs.     

Controlled Direct and Mediated Effects: Definition,Identification and Bounds

Abstract. Results are given which provide bounds for controlled direct effects when nounmeasured confounding assumptions required for the identification of these effects do not hold. Previous results concerning bounds for controlled direct effects rely on monotonicity relationships between the treatment, mediator and the outcome themselves; the results presented in this article instead assume that monotonicity relationships hold between the unmeasured confounding variable or variables and the treatment, mediator and outcome. Whereas prior results give bounds that contain the null hypothesis of no direct effect, the results presented here will in many instances yield bounds that do not contain the null hypothesis of no direct effect. For contexts in which a set of variables intercepts all paths between a treatment and an outcome, it is possible to provide a definition for a controlled mediated effect. We discuss the identification of these controlled mediated effects; the bounds for controlled direct effects are applicable also to controlled mediated effects. An example is given to illustrate how the results in the article can be used to draw inferences about direct and mediated effects in the presence of unmeasured confounding variables.     

Locally optimal designs for the simple death process

We demonstrate the existence and uniqueness of optimal observation schedules for discrete observation of the simple death process. Optimality is framed in the sense of observing the process at times that maximise the Fisher information for the death rate. We examine the relationship of our designs with those obtained by other authors for the simple birth process. A number of interesting properties are uncovered. Practical considerations in the application of these designs in an experimental setting are investigated, and we examine the performance of some approximately optimal designs that are usually simpler to implement. We will show that our optimal designs are highly robust to mis-specification of the death rate.     

On calculating the fisher information in order statistics

This article gives a simple result for the expression of the Fisher information in order statistics. This result enables us to calculate easily the Fisher information in any set of order statistics whose details have been known to be messy and complicated. We consider here its application in the optimal spacing problem where the exact Fisher information in order statistics has been approximated with the asymptotic information or the reciprocal of the variance of a suitable estimator. This work was supported by Korea Research Foundation Grant(KRF-2000-015-DP0056)     

安徽省旅游业跨越式发展的战略思考

面对旅游业白热化的市场竞争,安徽旅游业要想实现省政府提出的战略目标——在2010年把我省旅游业培育成国民经济的支柱产业,就必须跨越式发展。安徽省旅游业实现跨越式发展的条件已经成熟,但还有一系列障碍急待排除,从战略高度考虑,安徽省旅游业跨越式发展可实行7条行动对策。