Confidence estimation via the parametric bootstrap in logistic joinpoint regression

We consider asymptotic properties of the maximum likelihood and related estimators in a clustered logistic joinpoint model with an unknown joinpoint. Sufficient conditions are given for the consistency of confidence bounds produced by the parametric bootstrap; one of the conditions required is that the true location of the joinpoint is not at one of the observation times. A simulation study is presented to illustrate the lack of consistency of the bootstrap confidence bounds when the joinpoint is an observation time. A removal algorithm is presented which corrects this problem, but at the price of an increased mean square error. Finally, the methods are applied to data on yearly cancer mortality in the US for individuals age 65 and over.     

Mixture cure model with an application to interval mapping of quantitative trait loci

When censored time-to-event data are used to map quantitative trait loci (QTL), the existence of nonsusceptible subjects entails extra challenges. If the heterogeneous susceptibility is ignored or inappropriately handled, we may either fail to detect the responsible genetic factors or find spuriously significant locations. In this article, an interval mapping method based on parametric mixture cure models is proposed, which takes into consideration of nonsusceptible subjects. The proposed model can be used to detect the QTL that are responsible for differential susceptibility and/or time-to-event trait distribution. In particular, we propose a likelihood-based testing procedure with genome-wide significance levels calculated using a resampling method. The performance of the proposed method and the importance of considering the heterogeneous susceptibility are demonstrated by simulation studies and an application to survival data from an experiment on mice infected with Listeria monocytogenes.     

Non linear parametric mode regression

In this article, we propose a semi-parametric mode regression for a non linear model. We use an expectation-maximization algorithm in order to estimate the regression coefficients of modal non linear regression. We also establish asymptotic properties for the proposed estimator under assumptions of the error density. We investigate the performance through a simulation study.     

Estimating the structural dimension of regressions via parametric inverse regression

A new estimation method for the dimension of a regression at the outset of an analysis is proposed. A linear subspace spanned by projections of the regressor vector X , which contains part or all of the modelling information for the regression of a vector Y on X , and its dimension are estimated via the means of parametric inverse regression. Smooth parametric curves are fitted to the p inverse regressions via a multivariate linear model. No restrictions are placed on the distribution of the regressors. The estimate of the dimension of the regression is based on optimal estimation procedures. A simulation study shows the method to be more powerful than sliced inverse regression in some situations.     

A new goodness-of-fit test for certain bivariate distributions applicable to traffic accidents

T. Cacoullos and H. Papageorgiou [On some bivariate probability models applicable to traffic accidents and fatalities, Int. Stat. Rev. 48 (1980) 345–356] studied a special class of bivariate discrete distributions appropriate for modeling traffic accidents, and fatalities resulting therefrom. The corresponding random variable may be written as $Z={(N,Y)}^{\prime }$, with $Y={\sum }_{j=1}^N{X}_j$, where ${\left\{X_j\right\}}_{j=1}^N$, are independent copies of a (discrete) random variable $X$, and $N$ is independent of ${\left\{X_j\right\}}_{j=1}^N$, and follows a Poisson law. If $X$ follows a Poisson law (resp. Binomial law), the resulting distribution is termed Poisson–Poisson (resp. Poisson–Binomial). L2-type goodness-of-fit statistics are constructed for the ‘general distribution’ of this kind, where $X$ may be an arbitrary discrete nonnegative random variable. The test statistics utilize a simple characterization involving the corresponding probability generating function, and are shown to be consistent. The proposed procedures are shown to perform satisfactorily in simulated data, while their application to accident data leads to positive conclusions regarding the modeling ability of this class of bivariate distributions.     

上证指数波动率和收益率长期依赖关系的实证研究

运用经典的和修正过的重标极差方法研究了在1999到2009上证指数中的波动率和收益率的长期依赖关系。运用具有预白（pre-whitening）和后黑（postblackening）的Moving block bootstrap方法为假设检验构建置信区间。结果显示上证指数的收益率没有显著的长期相关。但是,波动率具有显著的长期相关。关于收益率的研究和之前一些研究提出的中国股票市场具有可持续性的结论相抵触。并且,之前这方面的研究大多数没有运用置信区间或只是基于标准正态分布的置信区间。因此,这些研究的结果需要从新检验和从新进行解释。     

A resampling approach to estimate variance components of multilevel models

In a multilevel model for complex survey data, the weight‐inflated estimators of variance components can be biased. We propose a resampling method to correct this bias. The performance of the bias corrected estimators is studied through simulations using populations generated from a simple random effects model. The simulations show that, without lowering the precision, the proposed procedure can reduce the bias of the estimators, especially for designs that are both informative and have small cluster sizes. Application of these resampling procedures to data from an artificial workplace survey provides further evidence for the empirical value of this method. The Canadian Journal of Statistics 40: 150–171; 2012 © 2012 Statistical Society of Canada     

Lower confidence bounds for percentiles of weibull and birnbaum-saunders distributions

Approximate lower confidence bounds on percentiles of the Weibull and the Birnbaum-Saunders distributions are investigated. Asymptotic lower confidence bounds based on Bonferroni's inequality and the Fisher information are discussed, and parametric bootstrap methods to provide better bounds are considered. Since the standard percentile bootstrap method typically does not perform well for confidence bounds on quantiles, several other bootstrap procedures are studied via extensive computer simulations. Results of the simulations indicate that the bootstrap methods generally give sharper lower bounds than the Bonferroni bounds but with coverages still near the nominal confidence level. Two illustrative examples are also presented, one for tensile strength of carbon micro-composite specimens and the other for cycles-to-failure data.     

Parameter and reliability estimation for an exponentiated half-logistic distribution under progressive type II censoring

In this article, we deal with a two-parameter exponentiated half-logistic distribution. We consider the estimation of unknown parameters, the associated reliability function and the hazard rate function under progressive Type II censoring. Maximum likelihood estimates (M LEs) are proposed for unknown quantities. Bayes estimates are derived with respect to squared error, linex and entropy loss functions. Approximate explicit expressions for all Bayes estimates are obtained using the Lindley method. We also use importance sampling scheme to compute the Bayes estimates. Markov Chain Monte Carlo samples are further used to produce credible intervals for the unknown parameters. Asymptotic confidence intervals are constructed using the normality property of the MLEs. For comparison purposes, bootstrap-p and bootstrap-t confidence intervals are also constructed. A comprehensive numerical study is performed to compare the proposed estimates. Finally, a real-life data set is analysed to illustrate the proposed methods of estimation.     

An estimating equation for parametric shared frailty models with marginal additive hazards

Summary.  Multivariate failure time data arise when data consist of clusters in which the failure times may be dependent. A popular approach to such data is the marginal proportional hazards model with estimation under the working independence assumption. In some contexts, however, it may be more reasonable to use the marginal additive hazards model. We derive asymptotic properties of the Lin and Ying estimators for the marginal additive hazards model for multivariate failure time data. Furthermore we suggest estimating equations for the regression parameters and association parameters in parametric shared frailty models with marginal additive hazards by using the Lin and Ying estimators. We give the large sample properties of the estimators arising from these estimating equations and investigate their small sample properties by Monte Carlo simulation. A real example is provided for illustration.