Distribution of Exposure Concentrations and Doses for Constituents of Environmental Tobacco Smoke

The ultimate goal of the research reported in this series of three articles is to derive distributions of doses of selected environmental tobacco smoke (ETS)-related chemicals for nonsmoking workers. This analysis uses data from the 16-City Study collected with personal monitors over the course of one workday in workplaces where smoking occurred. In this article, we describe distributions of ETS chemical concentrations and the characteristics of those distributions (e.g., whether the distribution was log normal for a given constituent) for the workplace exposure. Next, we present population parameters relevant for estimating dose distributions and the methods used for estimating those dose distributions. Finally, we derive distributions of doses of selected ETS-related constituents obtained in the workplace for people in smoking work environments. Estimating dose distributions provided information beyond the usual point estimate of dose and showed that the preponderance of individuals exposed to ETS in the workplace were exposed at the low end of the dose distribution curve. The results of this analysis include estimations of hourly maxima and time-weighted average (TWA) doses of nicotine from workplace exposures to ETS (extrapolated from 1 day to 1 week) and doses derived from modeled lung burdens of ultraviolet-absorbing particulate matter (UVPM) and solanesol resulting from workplace exposures to ETS (extrapolated from 1 day to 1 year).     

Percentage points of the statistics for testing hypotheses on mean vectors of multivariate normal distributions with missing observations

A problem of testing of hypotheses on the mean vector of a multivariate normal distribution with unknown and positive definite covariance matrix is considered when a sample with a special, though not unusual, pattern of missing observations from that population is available. The approximate percentage points of the test statistic are obtained and their accuracy has been checked by comparing them with some exact percentage points which are calculated for complete samples and some special incomplete samples. The approximate percentage points are in good agreement with exact percentage points. The above work is extended to the problem of testing the hypothesis of equality of two mean vectors of two multivariate normal distributions with the same, unknown covariance matrix     

A procedure for testing the equality of k dependent correlation coefficients

A procedure is proposed for testing the equality of k dependent correlation coefficients. The procedure is simulated utilizing Monte Carlo techniques; and, a method for post hoc probing is also suggested.     

Monte carlo estimates of the distributions of the random polygons of the voronoi tessellation with respect to a poisson process

A large-scale study, in which two million random Voronoi polygons (with respect to a homogeneous Poisson point process) were generated and mensurated, is described. The polygon characteristics recorded are number of sides (or vertices), perimeter, area and interior angles. A feature is the efficient “quantile” method of replicating Poisson-type random structures, which it is hoped may find useful application elsewhere.     

All pairwise comparisons of exponential location parameters under type i censoring — equal scale parameter case

In this paper, procedures for all pairwise comparisons of location parameters of negative exponential populations are developed when the common scale parameter is known or unknown using large sample distributional approximations of the relevant random variables. The small sample performance of these procedures are then examined using Monte Carlo simulation.     

Linear Models with Doubly Exchangeable Distributed Errors

We study the general linear model (GLM) with doubly exchangeable distributed error for m observed random variables. The doubly exchangeable general linear model (DEGLM) arises when the m-dimensional error vectors are “doubly exchangeable,” jointly normally distributed, which is a much weaker assumption than the independent and identically distributed error vectors as in the case of GLM or classical GLM (CGLM). We estimate the parameters in the model and also find their distributions. We show that the tests of intercept and slope are possible in DEGLM as a particular case using parametric bootstrap as well as multivariate Satterthwaite approximation.