A multistate approach for estimating the incidence of human immunodeficiency virus by using data from a prevalent cohort study

Summary.  Cohort studies of individuals infected with the human immunodeficiency virus (HIV) provide useful information on the past pattern of HIV diagnoses, progression of the disease and use of antiretroviral therapy. We propose a new method for using individual data from an open prevalent cohort study to estimate the incidence of HIV, by jointly modelling the HIV diagnosis, the inclusion in the cohort and the progression of the disease in a Markov model framework. The estimation procedure involves the construction of a likelihood function which takes into account the probability of observing the total number of subjects who are enrolled in the cohort and the probabilities of passage through the stages of disease for each observed subject conditionally on being included in the cohort. The estimator of the HIV infection rate is defined as the function which maximizes a penalized likelihood, and the solution of this maximization problem is approximated on a basis of cubic M -splines. The method is illustrated by using cohort data from a hospital-based surveillance system of HIV infection in Aquitaine, a region of south-western France. A simulation study is performed to study the ability of the model to reconstruct the incidence of HIV from prevalent cohort data.     

Smoothing spline Gaussian regression: more scalable computation via efficient approximation

Summary.  Smoothing splines via the penalized least squares method provide versatile and effective nonparametric models for regression with Gaussian responses. The computation of smoothing splines is generally of the order O ( n ³), n being the sample size, which severely limits its practical applicability. We study more scalable computation of smoothing spline regression via certain low dimensional approximations that are asymptotically as efficient. A simple algorithm is presented and the Bayes model that is associated with the approximations is derived, with the latter guiding the porting of Bayesian confidence intervals. The practical choice of the dimension of the approximating space is determined through simulation studies, and empirical comparisons of the approximations with the exact solution are presented. Also evaluated is a simple modification of the generalized cross-validation method for smoothing parameter selection, which to a large extent fixes the occasional undersmoothing problem that is suffered by generalized cross-validation.     

A framework for progressively improving small area population estimates

Summary.  The paper presents a framework for small area population estimation that enables users to select a method that is fit for the purpose. The adjustments to input data that are needed before use are outlined, with emphasis on developing consistent time series of inputs. We show how geographical harmonization of small areas, which is crucial to comparisons over time, can be achieved. For two study regions, the East of England and Yorkshire and the Humber, the differences in output and consequences of adopting different methods are illustrated. The paper concludes with a discussion of how data, on stream since 1998, might be included in future small area estimates.     

Bayesian Analysis of DNA Profiling Data in Forensic Identification Applications

The utilization of DNA evidence in cases of forensic identification has become widespread over the last few years. The strength of this evidence against an individual standing trial is typically presented in court in the form of a likelihood ratio (LR) or its reciprocal (the profile match probability). The value of this LR will vary according to the nature of the genetic relationship between the accused and other possible perpetrators of the crime in the population. This paper develops ideas and methods for analysing data and evaluating LRs when the evidence is based on short tandem repeat profiles, with special emphasis placed on a Bayesian approach. These are then applied in the context of a particular quadruplex profiling system used for routine case-work by the UK Forensic Science Service.     

Likelihood Estimation for Censored Random Vectors

This article shows how to construct a likelihood for a general class of censoring problems. This likelihood is proven to be valid, i.e. its maximizer is consistent and the respective root-n estimator is asymptotically efficient and normally distributed under regularity conditions. The method generalizes ordinary maximum likelihood estimation as well as several standard estimators for censoring problems (e.g. tobit type I-tobit type V).     

层次分析法在企业筹资决策中的应用研究

将运筹学中的层次分析法应用于企业的筹资决策中,可以减少企业筹资决策的盲目性。本文在建立了筹资决策的层次分析模型的基础上,进行了实证分析并指出了应用此方法应注意的问题。     

Tests of specification in econometrics

This survey of recent developments in testing for misspecification of econometric models reviews procedures based on a method due to Hausman. Particular attention is given to alternative forms of the test, its relationship to classical test procedures, and its role in pre-test estimation.     

ESTIMATING THE COMMON MEAN OF A BIVARIATE NORMAL POPULATION

For estimating the common mean of a bivariate normal distribution, Krishnamoorthy & Rohatgi (1989) proposed some estimators which dominate the maximum likelihood estimator in a large region of the parameter space. We consider some modifications of these estimators and study their risk performance.     

A stochastic Newton-Raphson method

A stochastic approximation procedure of the Robbins-Monro type is considered. The original idea behind the Newton-Raphson method is used as follows. Given n approximations X₁,…, X_n with observations Y₁,…, Y_n, a least squares line is fitted to the points (X_m, Y_m),…, (X_n, Y_n) where m<n may depend on n. The (n+1)st approximation is taken to be the intersection of the least squares line with y=0. A variation of the resulting process is studied. It is shown that this process yields a strongly consistent sequence of estimates which is asymptotically normal with minimal asymptotic variance.     

Some New Results on Likelihood Ratio Orderings for Spacings of Heterogeneous Exponential Random Variables

Let X ₁, X ₂,…, X _n be independent exponential random variables with X _i having failure rate λ _i for i = 1,…, n. Denote by D _i:n  = X _i:n  ? X _i?1:n the ith spacing of the order statistics X _1:n  ≤ X _2:n  ≤ ··· ≤ X _n:n , i = 1,…, n, where X _0:n ≡ 0. It is shown that if λ _n+1 ≤ [≥] λ _k for k = 1,…, n then D _n:n  ≤ _lr D _n+1:n+1 and D _1:n  ≤ _lr D _2:n+1 [D _2:n+1 ≤ _lr D _2:n ], and that if λ _i  + λ _j  ≥ λ _k for all distinct i,j, and k then D _n?1:n  ≤ _lr D _n:n and D _n:n+1 ≤ _lr D _n:n , where ≤ _lr denotes the likelihood ratio order. We also prove that D _1:n  ≤ _lr D _2:n for n ≥ 2 and D _2:3 ≤ _lr D _3:3 for all λ _i 's.