Bounding the resampling risk for sequential Monte Carlo implementation of hypothesis tests

Sequential designs can be used to save computation time in implementing Monte Carlo hypothesis tests. The motivation is to stop resampling if the early resamples provide enough information on the significance of the p-value of the original Monte Carlo test. In this paper, we consider a sequential design called the B-value design proposed by Lan and Wittes and construct the sequential design bounding the resampling risk, the probability that the accept/reject decision is different from the decision from complete enumeration. For the B-value design whose exact implementation can be done by using the algorithm proposed in Fay, Kim and Hachey, we first compare the expected resample size for different designs with comparable resampling risk. We show that the B-value design has considerable savings in expected resample size compared to a fixed resample or simple curtailed design, and comparable expected resample size to the iterative push out design of Fay and Follmann. The B-value design is more practical than the iterative push out design in that it is tractable even for small values of resampling risk, which was a challenge with the iterative push out design. We also propose an approximate B-value design that can be constructed without using a specially developed software and provides analytic insights on the choice of parameter values in constructing the exact B-value design.     

Using quantile averages in matched observational studies

In two observational studies, one investigating the effects of minimum wage laws on employment and the other of the effects of exposures to lead, an estimated treatment effect's sensitivity to hidden bias is examined. The estimate uses the combined quantile averages that were introduced in 1981 by B. M. Brown as simple, efficient, robust estimates of location admitting both exact and approximate confidence intervals and significance tests. Closely related to Gastwirth's estimate and Tukey's trimean, the combined quantile average has asymptotic efficiency for normal data that is comparable with that of a 15% trimmed mean, and higher efficiency than the trimean, but it has resistance to extreme observations or breakdown comparable with that of the trimean and better than the 15% trimmed mean. Combined quantile averages provide consistent estimates of an additive treatment effect in a matched randomized experiment. Sensitivity analyses are discussed for combined quantile averages when used in a matched observational study in which treatments are not randomly assigned. In a sensitivity analysis in an observational study, subjects are assumed to differ with respect to an unobserved covariate that was not adequately controlled by the matching, so that treatments are assigned within pairs with probabilities that are unequal and unknown. The sensitivity analysis proposed here uses significance levels, point estimates and confidence intervals based on combined quantile averages and examines how these inferences change under a range of assumptions about biases due to an unobserved covariate. The procedures are applied in the studies of minimum wage laws and exposures to lead. The first example is also used to illustrate sensitivity analysis with an instrumental variable.     

Accommodating stochastic departures from percentile invariance in causal models

Summary.  Consider a clinical trial in which participants are randomized to a single-dose treatment or a placebo control and assume that the adherence level is accurately recorded. If the treatment is effective, then good adherers in the treatment group should do better than poor ad- herers because they received more drug; the treatment group data follow a dose–response curve. But, good adherers to the placebo often do better than poor adherers, so the observed adherence–response in the treatment group cannot be completely attributed to the treatment. Efron and Feldman proposed an adjustment to the observed adherence–response in the treatment group by using the adherence–response in the control group. It relies on a percentile invariance assumption under which each participant's adherence percentile within their assigned treatment group does not depend on the assigned group (active drug or placebo). The Efron and Feldman approach is valid under percentile invariance, but not necessarily under departures from it. We propose an analysis based on a generalization of percentile invariance that allows adherence percentiles to be stochastically permuted across treatment groups, using a broad class of stochastic permutation models. We show that approximate maximum likelihood estimates of the underlying dose–response curve perform well when the stochastic permutation process is correctly specified and are quite robust to model misspecification.     

Maximizing a Family of Optimal Statistics over a Nuisance Parameter with Applications to Genetic Data Analysis

In this article, a simple algorithm is used to maximize a family of optimal statistics for hypothesis testing with a nuisance parameter not defined under the null hypothesis. This arises from genetic linkage and association studies and other hypothesis testing problems. The maximum of optimal statistics over the nuisance parameter space can be used as a robust test in this situation. Here, we use the maximum and minimum statistics to examine the sensitivity of testing results with respect to the unknown nuisance parameter. Examples from genetic linkage analysis using affected sub pairs and a candidate-gene association study in case-parents trio design are studied.     

Testing for Circular Reflective Symmetry about a Known Median Axis

Circular data arise in many contexts, a particularly rich source being animal orientation experiments. Often, in the analysis of such data, a fundamental question of scientific interest is whether the underlying distribution is reflectively symmetric about some specific axis. In this paper, the situation in which the axis of interest is known to be a median axis is considered and a simple, asymptotically distribution- free test for circular reflective symmetry against skew alternatives is developed. The results from a simulation study lead to a testing strategy incorporating the new test and the circular analogue of the modified runs test of Modarres & Gastwirth (1996). The application of the testing strategy is illustrated using circular data arising from two animal orientation experiments.     

Pooling multivariate data under W, LR and LM tests

Two independent random samples are drawn from two multivariate normal populations with mean vectors μ1 and μ2 and a common variance-covariance matrix Σ. Ahmed and Saleh (1990) considered preliminary test maximum likelihood estimator (PMLTE) for estimating μ1 based on the Hotelling's T _N ², when it is suspected that μ1=μ2. In this paper, the PTMLE based on the Wald (W), Likelihood Ratio (LR) and Lagrangian Multiplier (LM) tests are considered. Using the quadratic risk function, the conditions of superiority of the proposed estimator for departure parameter are derived. A max-min rule for the size of the preliminary test of significance is presented. It is demonstrated that the PTMLE based on W test produces the highest minimum guaranteed efficiencies compared to UMLE among the three test procedures.     

On a test for structural stability of euler conditions parameters estimated via the generalized method of moments estimator: small sample properties

This paper presents Monte Carlo experiments on the small sample performance of the predictive test for structural change proposed by Ghysels and Hall. The predictive test was found to be more powerful than the overidentifying restrictions test in terms of size-corrected power when a shift in parameter has occurred. Also, it was found that the power of the predictive test decreases drastically as the number of the out-sample data decreases.     

试析短跑放松技术的理论方法及检测

文章从生理学的角度,阐述了放松技术对提高短跑成绩的作用,认为放松技术主要指肌 肉放松。肌肉放松可增大肌肉的收缩力量和收缩速度,提高速度耐力和肌肉、关节的灵活性及柔 韧性。同时,从心理学的角度分析了短跑运动员的情绪、意志、自信心和竞争力等心理品质对肌 肉放松的影响,结合训练实践,针对性的提出了短跑放松训练方法和检测手段。     

Saddlepoint approximations for some models of circular data

In this article we provide saddlepoint approximations for some important models of circular data. The particularity of these saddlepoint approximations is that they do not require solving the saddlepoint equation iteratively, so their evaluation is immediate. We first give very accurate approximations to P-values, critical values and power functions for some optimal tests regarding the concentration parameter under wrapped symmetric α-stable and circular normal models. Then, we consider an approximation to the distribution of a projection of the two-dimensional Pearson random walk with exponential step sizes.