Spatial Matching of Multiple Configurations of Points with a Bioinformatics Application

In this article, we present a general model to deal with the problem of matching multiple objects or configurations of points from a Bayesian point of view. We study both labeled and non labeled cases. Our model generalizes, in terms of non singular affine transformations and multiple configurations, previous two-terms matching models. As a practical application in Bioinformatics, we consider data from a microarray experiment of gorilla, bonobo, and human-cultured fibroblasts. We find out the matchings and the best affine transformation between the projections of genes on a two-dimensional space, obtained by a multidimensional scaling technique.     

A Note on the Poisson Likelihood Ratio Test Statistic for Kulldorff's Scan Methods

Methods based on scan statistics are widely used in health-related applications to detect clusters of disease. The most common methods are based on the Bernoulli and Poisson models. Kulldorff (1997 Kulldorff , M. ( 1997 ). A spatial scan statistic . Communications in Statistics—Theory and Methods 26 : 1481 – 1496 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) derived the likelihood ratio test statistic for his scan method for both of these models. His scan statistic is widely used with freely available software, SaTScan^? (see Kulldorff, 2005 Kulldorff , M. ( 2005 ). SaTScan: software for the spatial, temporal, and space-time scan statistics , version 5.1 [computer program]. Information Management Services 2005; Available: http://www.satscan.org/. Accessed July 2007 . [Google Scholar]). We provide an alternative derivation of the likelihood ratio test statistic in the Poisson case. Our derivation is simpler and more general in the sense that it applies when the incidences are not aggregated into subregional counts.     

Exchange option in a two-state Poisson CAPM

In this paper we derive the pricing formula for the exchange option value in a two-state Poisson CAPM. A two-state Poisson CAPM models the stochastic market environment. We also provide examples and graphs to illustrate our result.     

Analyzing Cohort Mortality Data

Several methods for analyzing data from mortality studies of occupationally or environmentally exposed cohorts are shown to be special cases of a single procedure. The procedure assumes a proportional hazards model for exposure effects and represents the log-likelihood kernel for the data as that of N independent Poisson variates, where N is the total number of person-units of mortality observation time in the study. It formalizes and justifies the epidemiological techniques of classifying deaths and person-months of study time into categories defined by exposure and other covariates, and of computing standardized mortality ratios and indirectly standardized death rates. Parameters representing exposure effects can be estimated by using standard software packages. Special cases and applications are described in the context of lung cancer mortality among U.S. uranium miners.     

The robustness of the likelihood ratio test,the nonparametric sum rank test,and f-ratio tests when the populations are from the negative binomial family

In this study, the robustness of power and significance level of several statistical testing methods was evaluated under the assumption that the test populations were from Poisson, negative binomial, or geometric distributions. The F-ratio test, with or without appropriate transformations, was shown to be both safe and robust for all distributions examined.     

Looking for a Grandview: introducing concepts of robust sampling to policymakers and practitioners engaged in measuring the well‐being of children at the local authority level

Local authorities are increasingly required to measure and monitor the well‐being of children. One key aspect of ensuring that these data on child well‐being are robust is that they form an accurate and representative picture of that child population. Rather than being only the purview of researchers, the act of gathering outcome data now falls within the remit of policymakers and practitioners. This article therefore describes the principles and importance of solid sampling methodologies to this audience and also considers the practical reasons as to why policymakers and practitioners may require larger samples than may be necessary for a representative picture of child well‐being. These ideas are illustrated by one local authority in the UK’s approach to measuring child well‐being, using representative sampling techniques and the subsequent expansion of this sample. The consequences of expanding the sample size are illustrated by examining the impact upon key findings related to child well‐being. The potential benefits and limitations of larger samples are discussed, as are some practical solutions to the apparent impasse.     

Objective Bayesian Testing of a Poisson Mean

We consider testing hypotheses about a single Poisson mean. When prior information is not available, use of objective priors is of interest. We provide intrinsic priors based on the arithmetic intrinsic and fractional Bayes factors, and evaluate their characteristics.     

The Dynamic Model for Cancer Relapse Based on Two-Stage Model of Carcinogenesis

In this article, the time from the start of chemotherapy randomization until cancer relapse is of primary interest. Here, cancer relapse refers to the appearance of the first observable malignant clone after therapy. A dynamic model for cancer relapse after chemotherapy is developed. The model differs from the traditional cure rate models in that it takes into consideration the growth kinetics of malignant tumors using a two-stage carcinogenesis model. The survival and hazard functions for cancer relapse time are derived, and a simulation study is performed to validate the underlying model.     

The Poisson Generalized Linear Failure Rate Model

We formulate a new cure rate survival model by assuming that the number of competing causes of the event of interest has the Poisson distribution, and the time to this event has the generalized linear failure rate distribution. A new distribution to analyze lifetime data is defined from the proposed cure rate model, and its quantile function as well as a general expansion for the moments is derived. We estimate the parameters of the model with cure rate in the presence of covariates for censored observations using maximum likelihood and derive the observed information matrix. We obtain the appropriate matrices for assessing local influence on the parameter estimates under different perturbation schemes and present some ways to perform global influence analysis. The usefulness of the proposed cure rate survival model is illustrated in an application to real data.