Use of prior information for estimating the variance components

The MINQUE and its modifications are considered for estimating the variances of the balanced one-way random effects model. The effects of the a priori values on the estimators of the variances are examined in detail. The Mean Square Errors of the estimators are compared for variations in the prior values of the unknown variances.     

Assessing Effects on Long-term Survival after Early Termination of Randomized Trials

In this paper we present an approach to using historical control data to augment information from a randomized controlled clinical trial, when it is not possible to continue the control regimen to obtain the most reliable and valid assessment of long term treatment effects. Using an adjustment procedure to the historical control data, we investigate a method of estimating the long term survival function for the clinical trial control group and for evaluating the long term treatment effect. The suggested method is simple to interpret, and particularly motivated in clinical trial settings when ethical considerations preclude the long term follow-up of placebo controls. A simulation study reveals that the bias in parameter estimates that arises in the setting of group sequential monitoring will be attenuated when long term historical control information is used in the proposed manner. Data from the first and second National Wilms' Tumor studies are used to illustrate the method.     

Asymptotic properties of a generalized regression-type predictor of a finite population variance in probability sampling

A system of predictors for estimating a finite population variance is defined and shown to be asymptotically design-unbiased (ADU) and asymptotically design-consistent (ADC) under probability sampling. An asymptotic mean squared error (MSE) of a generalized regression-type predictor, generated from the system, is obtained. The suggested predictor attains the minimum expected variance of any design-unbiased estimator when the superpopulation model is correct. The generalized regression-type predictor and the predictor suggested by Mukhopadhyay (1990) are compared.     

Regression Analysis of Restricted Mean Survival Time Based on Pseudo-Observations

Regression models for survival data are often specified from the hazard function while classical regression analysis of quantitative outcomes focuses on the mean value (possibly after suitable transformations). Methods for regression analysis of mean survival time and the related quantity, the restricted mean survival time, are reviewed and compared to a method based on pseudo-observations. Both Monte Carlo simulations and two real data sets are studied. It is concluded that while existing methods may be superior for analysis of the mean, pseudo-observations seem well suited when the restricted mean is studied.     

Missing at random (MAR) in nonparametric regression - A simulation experiment

The additive model is considered when some observations on x are missing at random but corresponding observations on y are available. Especially for this model, missing at random is an interesting case because the complete case analysis is expected to be no more suitable. A simulation experiment is reported and the different methods are compared based on their superiority with respect to the sample mean squared error. Some focus is also given on the sample variance and the estimated bias. In detail, the complete case analysis, a kind of stochastic mean imputation, a single imputation and the nearest neighbor imputation are discussed.     

On the cohen-sackrowitz estimator of a common mean

The paper reconsider certain estimators proposed by COHENand SACKROWITZ[Ann.Statist.(1974)2,1274-1282,Ann.Statist.4,1294]for the common mean of two normal distributions on the basis of independent samples of equal size from the two populations. It derives the ncecessary and sufficient condition for improvement over the first sample mean, under squared error loss, for any member of a class containing these. It shows that the estimator proposded by them for simultaneous improvement over botyh sample means has the desired property if and only if the common size of the samples is at least nine. The requirement is milder than that for any other estimator at the present state of knolwledge and may be constrasted with their result which implies the desired property of the estimator only if the common size of the samples is at least fifteen. Upper bounds for variances if the estimators derived by them are also improved     

The estimation of derivatives of a nonparametric regression function when the data are correlated

A kernel estimator of a derivative of arbitrary order of a nonparametric average population curve is considered for a correlated-errors model with balanced replicate measurements at each design point. Asymptotic expansions of the mean squared error are derived for two classes of correlation functions in the model. Consistency, choice of smoothing parameter, and rates of convergence are examined for the important special cases of estimating the first and second derivatives.     

Admissible minimum bias estimation of response surfaces

The minimum bias estimator was introduced as an alternative to the least squares estimator for approximating response functions by low-order polynomials. Here we show how to obtain an admissible estimator with smaller squared bias.     

Kernel estimation of a distribution function

A distribution function is estimated by a kernel method with

a poinrwise mean squared error criterion at a point x. Relation- ships between the mean squared error, the point x, the sample size and the required kernel smoothing parazeter are investigated for several distributions treated by Azzaiini (1981). In particular it is noted that at a centre of symmetry or near a mode of the distribution the kernei method breaks down. Point- wise estimation of a distribution function is motivated as a more useful technique than a reference range for preliminary medical diagnosis.     

Asymptotic risk comparisions of restricted and unrestricted maximum likelihood estimators

Conditions for choosing between restricted and unrestrieted maximum likelihood estimators based on various asymptotic risk oriteria are derived. These conditions involve the non-centrality parameters of classical and specification test statistics, and are generlizations of well known results for the linear regression model.