Accurate computation of single and product moments of order statistics under progressive censoring

An accurate procedure is proposed to calculate approximate moments of progressive order statistics in the context of statistical inference for lifetime models. The study analyses the performance of power series expansion to approximate the moments for location and scale distributions with high precision and smaller deviations with respect to the exact values. A comparative analysis between exact and approximate methods is shown using some tables and figures. The different approximations are applied in two situations. First, we consider the problem of computing the large sample variance–covariance matrix of maximum likelihood estimators. We also use the approximations to obtain progressively censored sampling plans for log-normal distributed data. These problems illustrate that the presented procedure is highly useful to compute the moments with precision for numerous censoring patterns and, in many cases, is the only valid method because the exact calculation may not be applicable.     

Stress-strength reliability of exponentiated Fréchet distributions based on Type-II censored data

In this paper, we consider inference of the stress-strength parameter, R, based on two independent Type-II censored samples from exponentiated Fréchet populations with different index parameters. The maximum likelihood and uniformly minimum variance unbiased estimators, exact and asymptotic confidence intervals and hypotheses testing for R are obtained. We conduct a Monte Carlo simulation study to evaluate the performance of these estimators and confidence intervals. Finally, two real data sets are analysed for illustrative purposes.     

Prediction of future failures times based on Type-I hybrid censored samples of random sample sizes

In this article, we consider the prediction of future failure times based on Type-I hybrid censored samples. Point predictors and prediction intervals using different procedures are discussed for a general model. The exponential and Rayleigh distributions are used as illustrative examples to show the most simplified forms of the so obtained predictors as well as prediction intervals. Intensive simulation study and a real life dataset are presented to illustrate our findings and results.     

A volume based approach to establish B-spline based expressions for density functions and its application to progressive hybrid censoring

We propose an approach to determine the distribution of particular linear combinations of hybrid censored order statistics which is based on the calculation of volumes of polytopes. For this purpose, we establish efficient and compact volume formulas in terms of B-splines. Further, we illustrate our approach for ten different progressive hybrid censoring schemes under an exponential assumption.     

Diabetes education program for people with type 2 diabetes: An international perspective

BackgroundIn the Palestinian community, lifestyle changes, rapid urbanization and socioeconomic development, stress, smoking, and changes in food habits has increased the risk of non-communicable diseases especially diabetes mellitus. Diabetes complications can be prevented if the glycemic status of patients with diabetes is maintained within a nearly normal range. Therefore, patient education is critical in controlling blood glucose levels within the normal range.ObjectiveThis study aimed at measuring the effect of diabetes educational intervention program for patients suffering from type 2 diabetes attending the Diabetes Clinic in Tulkarim Directorate of Health.MethodsA short duration observational study involving pre- and post-test educational intervention program was carried out on a relatively small number of type 2 diabetes patients at the Diabetes Clinic in Tulkarim Directorate of Health. In total, 215 patients attended a group-based 4 h educational intervention session about diabetes. The program included explaining diabetes mellitus-symptoms, risk factors, types, treatment and complications and main aspects of self-care of the disease (foot care, eye care, and blood glucose monitoring), main aspects of dietary management, weight reduction, blood pressure, smoking cessation, periodic investigations, home monitoring and importance of physical activity. Knowledge evaluation questionnaire were evaluated pre- and post-study. Anthropometric measurements such as body weight (WT), body mass index (BMI) and laboratory tests such as fasting blood glucose (FBG), hemoglobin A1C (HbA1c), cholesterol (Chol), and triglycerides (TG) were measured both at the beginning and at the end of the study. Significance of the results was assessed by paired t-test at 95% confidence interval.ResultsThe participant’s mean age was 51.07 that ranged between 31 and 70 years. For a total of 215 participants, 41.4% were males and 58.6% were females. The mean weight before educational intervention was 80.81 ± 14.95 kg (82.6 kg for males and 79.5 kg for females) that decreased to 78.9 ± 14.33 kg (81.1 kg for males and 77.3 kg for females) after educational intervention program. The BMI also decreased significantly after educational intervention. The mean fasting blood sugar was 188.65 ± 71.45 mg/dL before educational intervention that decreased to 177.7 ± 66.11 mg/dL after the educational intervention (p = 0.049). The mean glycosylated hemoglobin was 8.57 ± 1.21 before educational intervention that decreased to 7.95 ± 1.42 after educational intervention. The mean value of cholesterol before educational intervention was 183.27 ± 37.74 mg/dL that decreased to 169.57 ± 34.23 mg/dL after educational intervention. The mean triglycerides value decreased after educational intervention from 209.85 ± 171.04 mg/dL to 183.28 ± 152.4 mg/dL (p = 0.025). The mean score of knowledge questionnaire before educational intervention was 60.6 ± 20.65 that increased to 78.1 ± 13.4 after conducting educational intervention.ConclusionsDiabetes education was found to be effective on BMI, FBG, HbA1c, Chol, TG, and knowledge.RecommendationsDiabetes education is a cornerstone in the management and care of diabetes and should be an integral part of health planning involving patient’s family, diabetes care team, community, and decision makers in the education process.     

Influencing behaviour: The mindspace way

The ability to influence behaviour is central to many of the key policy challenges in areas such as health, finance and climate change. The usual route to behaviour change in economics and psychology has been to attempt to ‘change minds’ by influencing the way people think through information and incentives. There is, however, increasing evidence to suggest that ‘changing contexts’ by influencing the environments within which people act (in largely automatic ways) can have important effects on behaviour. We present a mnemonic, MINDSPACE, which gathers up the nine most robust effects that influence our behaviour in mostly automatic (rather than deliberate) ways. This framework is being used by policymakers as an accessible summary of the academic literature. To motivate further research and academic scrutiny, we provide some evidence of the effects in action and highlight some of the significant gaps in our knowledge.     

从确认到竞争:被选举权的民主建构

被选举权是标志和象征人民作为"主权者"的地位和身份之基本权利。公民依法主动竞争公共职位是被选举权作为民主权利的内在要求,也是市场经济需要竞争性政治的折射。被选举权的激活对于选拔政治人才,强化权力受托人的责任意识,推动公民参与,促进权力可持续发展,培养公民人格等具有特殊意义。规范被选举权的运作,需要建立和完善权力角逐的平等竞争规则、筛选过滤机制、对当选者的监督制约机制以及纠纷化解体系。     

Sex, self-interest and health care priorities

In this questionnaire study, individuals were asked to prioritise publicly provided preventive health care services, one of which would be unavailable to them by virtue of their sex. The aim was to establish whether men and women would exhibit different degrees of self-interest when making a constrained choice. Around 1800 subjects from east-central England prioritised three different types of cancer screening. Most also provided written explanations for their rankings and these were classified into explanatory themes. Logistic regressions using socio-demographic and attitude data predicted the type of screening chosen as first priority. The analysis revealed that many men and women did indeed assign similar priorities to the different types of screening and, even when the priorities differed, these were often justified by similar arguments relating to technical aspects of the interventions and to self-interest. However, women were far more likely than men to prioritise a type of screening from which they themselves would benefit directly and the variations in preferences and explanations between the sexes occurred primarily because of differences in other-regarding attitudes. The bias towards screening of females was driven by women's greater worries about the disease in question and by men's “benevolent sexism” with respect to women's wellbeing.     

社会学民族志的力量:重返早期社会研究的田野工作

自20世纪70年代以来,社会学民族志在田野工作和叙事复兴中与传统人文学汇聚,显著扩展了自己的学科边界。但是,这种扩展并没有解决社会学民族志在深度的经验发生和强烈的理论诉求之间遭遇的紧张。对于这种紧张,本文主张再访早期社会研究的田野,即19世纪末期到一战之前的若干典型研究,从中反思早期社会学田野工作是如何在“直接经验”的倾向中完成类型化,以及如何在这个经验感获得的同时改变对社会世界的道德想象。早期社会学的田野工作的力量之一不在于以规范的诉求压制经验感,而是以独特的情感结构连接经验的观察和道德理想的重生。由此,我们不仅需要反思诸如社会调查到社区研究这样的简单思路,更要重新理解理论史上所谓的“进步主义式”的道德本身。这一工作对重新认识早期社会研究和今天的社会学民族志都具有意义上的准备。     

Adaptive phase I/II clinical trials for drug combination assessment in oncology using the outcomes of each cycle

Many new anticancer agents can be combined with existing drugs, as combining a number of drugs may be expected to have a better therapeutic effect than monotherapy owing to synergistic effects. Furthermore, to drive drug development and to reduce the associated cost, there has been a growing tendency to combine these as phase I/II trials. With respect to phase I/II oncology trials for the assessment of dose combinations, in the existing methodologies in which efficacy based on tumor response and safety based on toxicity are modeled as binary outcomes, it is not possible to enroll and treat the next cohort of patients unless the best overall response has been determined in the current cohort. Thus, the trial duration might be potentially extended to an unacceptable degree. In this study, we proposed a method that randomizes the next cohort of patients in the phase II part to the dose combination based on the estimated response rate using all the available observed data upon determination of the overall response in the current cohort. We compared the proposed method to the existing method using simulation studies. These demonstrated that the percentage of optimal dose combinations selected in the proposed method is not less than that in the existing method and that the trial duration in the proposed method is shortened compared to that in the existing method. The proposed method meets both ethical and financial requirements, and we believe it has the potential to contribute to expedite drug development.