Response surface model diagnosis in two-way tables

Graphical model diagnosis procedures for two-way tables have already been proposed by Mandel, as well as by Bradu and Gabriel who used Gabriel's biplot as a main tool.

In this paper, a graphical model diagnosis extending Mandel's approach is developed. Response surface models are obtained whereby the response is expressed in terms of ‘truth-connected’ latent variates and, ultimately, in terms of originally measured external variates.

Meaningful models are obtained in some cases, accurate smoothing and interpolation algorithms in others.

As a by–product, Euclidean maps, which represent a twodimensional scaling (for rows or columns) also displaying ,ANOVA features, are obtained. To an extent, these maps can be viewed as a substitute for a model in the event of partial failure of the modelling operation.     

Confidence intervals and bands for the binormal ROC curve revisited

Two types of confidence intervals (CIs) and confidence bands (CBs) for the receiver operating characteristic (ROC) curve are studied: pointwise CIs and simultaneous CBs. An optimized version of the pointwise CI with the shortest width is developed. A new ellipse-envelope simultaneous CB for the ROC curve is suggested as an adaptation of the Working-Hotelling-type CB implemented in a paper by Ma and Hall (1993). Statistical simulations show that our ellipse-envelope CB covers the true ROC curve with a probability close to nominal while the coverage probability of the Ma and Hall CB is significantly smaller. Simulations also show that our CI for the area under the ROC curve is close to nominal while the coverage probability of the CI suggested by Hanley and McNail (1982) uniformly overestimates the nominal value. Two examples illustrate our simultaneous ROC bands: radiation dose estimation from time to vomiting and discrimination of breast cancer from benign abnormalities using electrical impedance measurements.     

Comparison of Some Mrpp and Standard Rank Tests for Two Unequal Samples

MRPP rank tests for two subgroups of unequal size are studied in detail. Based on the Pearson criteria, appropriate Pearson curves are suggested for their approximate distributions. On the basis ot extensive simulations, empirical powers of these tests are compared among themselves and with some standard nonparametric tests for several underlying populations.     

Empirical power comparisons of two mrpp rank tests

Simulated powers of the MRPP two-sample rank test statistic ?₁- are compared with the powers of the MRPP test statistic ?₂(the two-sided Wilcoxon-Mann-Whitney test) for large samples from several underlying populations. Powers are obtained using two approximate distributions of ?₁ involving three and four moments

respectively, The use of the fourth moment indicates that an approximation to the null distribution of ? based on four moments can perform better     

Comparison of Scoring Systems for Invasive Pests Using ROC Analysis and Monte Carlo Simulations

Different international plant protection organisations advocate different schemes for conducting pest risk assessments. Most of these schemes use structured questionnaire in which experts are asked to score several items using an ordinal scale. The scores are then combined using a range of procedures, such as simple arithmetic mean, weighted averages, multiplication of scores, and cumulative sums. The most useful schemes will correctly identify harmful pests and identify ones that are not. As the quality of a pest risk assessment can depend on the characteristics of the scoring system used by the risk assessors (i.e., on the number of points of the scale and on the method used for combining the component scores), it is important to assess and compare the performance of different scoring systems. In this article, we proposed a new method for assessing scoring systems. Its principle is to simulate virtual data using a stochastic model and, then, to estimate sensitivity and specificity values from these data for different scoring systems. The interest of our approach was illustrated in a case study where several scoring systems were compared. Data for this analysis were generated using a probabilistic model describing the pest introduction process. The generated data were then used to simulate the outcome of scoring systems and to assess the accuracy of the decisions about positive and negative introduction. The results showed that ordinal scales with at most 5 or 6 points were sufficient and that the multiplication‐based scoring systems performed better than their sum‐based counterparts. The proposed method could be used in the future to assess a great diversity of scoring systems.     

A modified area under the ROC curve and its application to marker selection and classification

The area under the ROC curve (AUC) can be interpreted as the probability that the classification scores of a diseased subject is larger than that of a non-diseased subject for a randomly sampled pair of subjects. From the perspective of classification, we want to find a way to separate two groups as distinctly as possible via AUC. When the difference of the scores of a marker is small, its impact on classification is less important. Thus, a new diagnostic/classification measure based on a modified area under the ROC curve (mAUC) is proposed, which is defined as a weighted sum of two AUCs, where the AUC with the smaller difference is assigned a lower weight, and vice versa. Using mAUC is robust in the sense that mAUC gets larger as AUC gets larger as long as they are not equal. Moreover, in many diagnostic situations, only a specific range of specificity is of interest. Under normal distributions, we show that if the AUCs of two markers are within similar ranges, the larger mAUC implies the larger partial AUC for a given specificity. This property of mAUC will help to identify the marker with the higher partial AUC, even when the AUCs are similar. Two nonparametric estimates of an mAUC and their variances are given. We also suggest the use of mAUC as the objective function for classification, and the use of the gradient Lasso algorithm for classifier construction and marker selection. Application to simulation datasets and real microarray gene expression datasets show that our method finds a linear classifier with a higher ROC curve than some other existing linear classifiers, especially in the range of low false positive rates.     

铸铁烘缸椭圆人孔盖的计算

为了解决铸铁烘缸承压元件椭圆形人孔盖设计计算的困扰,设计人员基于国内规范结合ASME规范寻求一种新 的设计计算方法,即利用ASME规范提供的数表找到适合于铸铁烘缸人孔盖材料的特性曲线,将此特性曲线提供的特性 数值代入已经成熟的算例当中,从而计算出人孔盖的承压能力。此方法一旦成熟可以解决椭圆形人孔盖设计计算的难 题,使铸铁烘缸人孔盖的设计进一步的优化     

A Framework for Analysis of Production Authorization Card‐Controlled Production Systems

A framework for the analysis of manufacturing systems operating under a production authorization card (PAC) system is outlined. The PAC system provides a single model, which encompasses a broad variety of control strategies, including Kanban and CONWIP. This paper describes a framework for the performance analysis and comparison of both specific and families of control strategies. The framework starts with system performance measures estimated by simulation. These simulations in turn provide training data for neural network metamodels. The metamodels allow for a variety of analysis and optimization approaches, including the construction of optimal policy curves, which can provide considerable insight into the systems under study.     

Testing equality of survival distributions when the population marks are missing

This paper introduces a nonparametric approach for testing the equality of two or more survival distributions based on right censored failure times with missing population marks for the censored observations. The standard log-rank test is not applicable here because the population membership information is not available for the right censored individuals. We propose to use the imputed population marks for the censored observations leading to fractional at-risk sets that can be used in a two sample censored data log-rank test. We demonstrate with a simple example that there could be a gain in power by imputing population marks (the proposed method) for the right censored individuals compared to simply removing them (which also would maintain the right size). Performance of the imputed log-rank tests obtained this way is studied through simulation. We also obtain an asymptotic linear representation of our test statistic. Our testing methodology is illustrated using a real data set.