Generalized RCINAR(p) Process with Signed Thinning Operator

We propose a new integer-valued time series process, called generalized pth-order random coefficient integer-valued autoregressive process with signed thinning operator. This kind of process is appropriate for modeling negative integer-valued time series; strict stationarity and ergodicity of the process are established. Estimators of the model's parameters are derived and their properties are studied via simulation. We apply our process to a real data example.     

Analyzing Binomial Data in a Split-Plot Design: Classical Approach or Modern Techniques?

Modeling data that are non-normally distributed with random effects is the major challenge in analyzing binomial data in split-plot designs. Seven methods for analyzing such data using mixed, generalized linear, or generalized linear mixed models are compared for the size and power of the tests. This study shows that analyzing random effects properly is more important than adjusting the analysis for non-normality. Methods based on mixed and generalized linear mixed models hold Type I error rates better than generalized linear models. Mixed model methods tend to have higher power than generalized linear mixed models when the sample size is small.     

On the asymptotic properties of parameter estimates in a regression model with non-normally distributed errors

As pointed out in a recent paper by Amirkhalkhali and Rao (1986) (henceforth referred to as A&R), the usual assumption of normality for the error terms of a regression model isoften untenable. However, when this assumption is dropped, it may be difficult to characterize parameter estimates for the model. For example, A&R (p. 189) state that “if the regression errors are non-normal, we are not even sure of their [e.g., the generalized least squares parameter estimates1] asymptotic properties.” A partial answer, however, is given by Spall and Wall (1984), which presents an asymptotic distribution theory for Kalman filter estimates for cases where the random terms of the state space model are not necessarily Gaussian. Certain of these asymptotic distribution results are also discussed in Spall (1985) in the context of model validation (diagnostic checking)     

ASYMPTOTIC AND SMALL SAMPLE STATISTICAL PROPERTIES OF RANDOM FRAILTY VARIANCE ESTIMATES FOR SHARED GAMMA FRAILTY MODELS

This paper concerns maximum likelihood estimation for the semiparametric shared gamma frailty model; that is the Cox proportional hazards model with the hazard function multiplied by a gamma random variable with mean 1 and variance θ. A hybrid ML-EM algorithm is applied to 26 400 simulated samples of 400 to 8000 observations with Weibull hazards. The hybrid algorithm is much faster than the standard EM algorithm, faster than standard direct maximum likelihood (ML, Newton Raphson) for large samples, and gives almost identical results to the penalised likelihood method in S-PLUS 2000. When the true value θ₀ of θ is zero, the estimates of θ are asymptotically distributed as a 50–50 mixture between a point mass at zero and a normal random variable on the positive axis. When θ₀ > 0, the asymptotic distribution is normal. However, for small samples, simulations suggest that the estimates of θ are approximately distributed as an x ? (100 ? x)% mixture, 0 ≤ x ≤ 50, between a point mass at zero and a normal random variable on the positive axis even for θ₀ > 0. In light of this, p-values and confidence intervals need to be adjusted accordingly. We indicate an approximate method for carrying out the adjustment.     

Optimal allocation of time points for the random effects model

In this article the problem of the optimal selection and allocation of time points in repeated measures experiments is considered. D‐ optimal designs for linear regression models with a random intercept and first order auto‐regressive serial correlations are computed numerically and compared with designs having equally spaced time points. When the order of the polynomial is known and the serial correlations are not too small, the comparison shows that for any fixed number of repeated measures, a design with equally spaced time points is almost as efficient as the D‐ optimal design. When, however, there is no prior knowledge about the order of the underlying polynomial, the best choice in terms of efficiency is a D‐ optimal design for the highest possible relevant order of the polynomial. A design with equally‐spaced time points is the second best choice     

On the Alias Method for Generating Random Variables from a Discrete Distribution

The alias method of Walker is a clever, new, fast method for generating random variables from an arbitrary, specified discrete distribution. A simple probabilistic proof is given, in terms of mixtures, that the method works for any discrete distribution with a finite number of outcomes. A more efficient version of the table-generating portion of the method is described. Finally, a brief discussion on efficiency of the method is given. We believe that the generality, speed, and simplicity of the method make it attractive for use in generating discrete random variables.     

New Developments in Statistical Computing: New Bias Evaluation Features of EXPLOR—A Program for Assessing Experimental Design Properties

Longitudinal investigations play an increasingly prominent role in biomedical research. Much of the literature on specifying and fitting linear models for serial measurements uses methods based on the standard multivariate linear model. This article proposes a more flexible approach that permits specification of the expected response as an arbitrary linear function of fixed and time-varying covariates so that mean-value functions can be derived from subject matter considerations rather than methodological constraints. Three families of models for the covariance function are discussed: multivariate, autoregressive, and random effects. Illustrations demonstrate the flexibility and utility of the proposed approach to longitudinal analysis.     

Review of Statistical Filmstrip Programs

We develop a novel nonparametric likelihood ratio test for independence between two random variables using a technique that is free of the common constraints of defining a given set of specific dependence structures. Our methodology revolves around an exact density-based empirical likelihood ratio test statistic that approximates in a distribution-free fashion the corresponding most powerful parametric likelihood ratio test. We demonstrate that the proposed test is very powerful in detecting general structures of dependence between two random variables, including nonlinear and/or random-effect dependence structures. An extensive Monte Carlo study confirms that the proposed test is superior to the classical nonparametric procedures across a variety of settings. The real-world applicability of the proposed test is illustrated using data from a study of biomarkers associated with myocardial infarction. Supplementary materials for this article are available online.     

Simple Counterexamples against the Conditionality Principle

The famous theorem of Birnbaum, stating that the likelihood principle follows from the conditionality principle together with the sufficiency principle, has caused much discussion among statisticians. Briefly, many writers dislike the consequences of the likelihood principle (among other things, confidence coefficients and levels of tests are dismissed as meaningless), but at the same time they feel that both the conditionality principle and the sufficiency principle are intuitively obvious. In the present article we give examples to show that the conditionality principle should not be taken to be of universal validity, and we discuss some consequences of these examples.     

Resolving the Mixed Models Controversy

Two standard mixed models with interactions are discussed. When each is viewed in the context of superpopulation models, the mixed models controversy is resolved. The tests suggested by the expected mean squares under the constrained-parameters model are correct for testing the main effects and interactions under both the unconstrained-and constrained-parameters models.