Assessing respondent-driven sampling: A simulation study across different networks

The purpose was to assess RDS estimators in populations simulated with diverse connectivity characteristics, incorporating the putative influence of misreported degrees and transmission processes. Four populations were simulated using different random graph models. Each population was “infected” using four different transmission processes. From each combination of population x transmission, one thousand samples were obtained using a RDS-like sampling strategy. Three estimators were used to predict the population-level prevalence of the “infection”. Several types of misreported degrees were simulated. Also, samples were generated using the standard random sampling method and the respective prevalence estimates, using the classical frequentist estimator. Estimation biases in relation to population parameters were assessed, as well as the variance. Variability was associated with the connectivity characteristics of each simulated population. Clustered populations yield greater variability and no RDS-based strategy could address the estimation biases. Misreporting degrees had modest effects, especially when RDS estimators were used. The best results for RDS-based samples were observed when the “infection” was randomly attributed, without any relation with the underlying network structure.     

大学生就业决定因素分析——基于多层模型的方法

本文利用山东2007届高校毕业生就业调查数据,建立多层交叉随机效应模型,检验了个体、专业和学校等多层变量对大学生就业的影响。结果发现,初次就业概率在学校和专业之间存在显著差异,且学校因素对就业的作用大于专业,但学校与专业对就业的交互作用不显著。就业能力以及与专业相关的实习经历对就业具有显著的正向作用。因此,大学生就业政策的重点是提高教育质量和突出专业特色,提升就业能力,完善就业导向的实习指导和服务。     

Asthma Patients' Activities and Air Pollution: A Semiparametric Censored Regression Analysis

Asthma patients' health status may be especially sensitive to some types of air pollution, but the evidence on this is mixed. We explore the effects of ground-level ozone on asthma patient's activities, breaking apart the usual aggregated category of leisure into indoor and outdoor activities, and differentiating those by whether the activities were active or inactive. Applying the semiparametric censored estimation method we demonstrate that even though the period over which activities were observed was relatively low in ozone levels, there is a significant impact of ozone on a few activities. The (non-ozone) economic and demographic variables in the model play significant roles in explaining the allocation of time among seven activities, suggesting the suitability of the approach for other household decision-making contexts.     

Optimal estimation of a finite population mean under generalized random permutation models

Employing certain generalized random permutation models and a general class of linear estimators of a finite population mean, it is shown that many of the conventional estimators are “optimal” in the sense of minimum average mean square error. Simple proofs are provided by using a well-known theorem on UMV estimation. The results also cover certain simple response error situations.     

Hypothesis group testing for disjoint pairs

Classical group testing (CGT) is a widely applicable biotechnical technique used to identify a small number of distinguished objects from a population when the presence of any one of these distinguished objects among a group of others produces an observable result. This paper discusses a variant of CGT called group testing for disjoint pairs (GTAP). The difference between the two is that in GTDP, the distinguished items are pairs from, not individual objects in, the population. There are several biological examples of when this abstract model applies. One biological example is DNA hybridization. The presence of pairs of hybridized DNA strands can be detected in a pool of DNA strands. Another situation is the detection of binding interactions between prey and bait proteins. This paper gives a random pooling method, similar in spirit to hypothesis testing, which identifies pairs of objects from a population that collectively have an observable function. This method is simply to apply, achieves good results, is amenable to automation and can be easily modified to compensate for testing errors. M.A. Bishop is supported by AFOSR FA8750-06-C-0007. A.J. Macula is supported by NSF-0436298, AFOSR FA8750-06-C-0007.     

Three-step estimation in linear mixed models with skew-t distributions

Linear mixed models based on the normality assumption are widely used in health related studies. Although the normality assumption leads to simple, mathematically tractable, and powerful tests, violation of the assumption may easily invalidate the statistical inference. Transformation of variables is sometimes used to make normality approximately true. In this paper we consider another approach by replacing the normal distributions in linear mixed models by skew-t distributions, which account for skewness and heavy tails for both the random effects and the errors. The full likelihood-based estimator is often difficult to use, but a 3-step estimation procedure is proposed, followed by an application to the analysis of deglutition apnea duration in normal swallows. The example shows that skew-t models often entail more reliable inference than Gaussian models for the skewed data.     

Decision Making in `Random in a Broad Sense' Environments

It is shown that the uncertainty connected with a `random in a broad sense' (not necessarily stochastic) event always has some `statistical regularity' (SR) in the form of a family of finite-additive probability distributions. The specific principle of guaranteed result in decision making is introduced. It is shown that observing this principle of guaranteed result leads to determine the one optimality criterion corresponding to a decision system with a given `statistical regularity'.     

A simulation study on power comparisons for group sequential tests of non-parametric statistics

In this article, a group sequential test (GST) of non-parametric statistics for survival data is briefly reviewed. An asymptotic joint distribution of the test statistics, obtained after each interim analysis, is given to illustrate the applicability of the critical values of the GST procedures. It should be noted that censored observations are generally seen in survival data. Therefore, if one makes power calculations irrespective of censoring, reliable results may not be achieved, due to the lack of information about the censoring structure. A wide simulation study, covering different censoring rates and tied observations, is conducted to make the power comparisons under various scenarios. The simulation results are interpreted and compared with the results obtained by using power analysis and sample size (PASS) software.     

An experiment in primary health care provision

Missing data and, more generally, imperfections in implementing a study design are an endemic problem in large scale studies involving human subjects. We present an analysis of an experiment in the interaction between general practitioners and their patients, in which the issue of missing data is addressed by a sensitivity analysis using multiple imputation. Instead of specifying a model for missingness we explore certain extreme ways of departing from the assumption of data missing at random and establish the largest extent of such departures which would still fail to supplant the evidence about the studied effect. An important advantage of the approach is that the algorithm intended for the complete data, to fit generalized linear models with random effects, is used without any alteration.