Acceleration of the Multiple-Try Metropolis algorithm using antithetic and stratified sampling

The Multiple-Try Metropolis is a recent extension of the Metropolis algorithm in which the next state of the chain is selected among a set of proposals. We propose a modification of the Multiple-Try Metropolis algorithm which allows for the use of correlated proposals, particularly antithetic and stratified proposals. The method is particularly useful for random walk Metropolis in high dimensional spaces and can be used easily when the proposal distribution is Gaussian. We explore the use of quasi Monte Carlo (QMC) methods to generate highly stratified samples. A series of examples is presented to evaluate the potential of the method.     

On the Breslow–Holubkov estimator

Breslow and Holubkov (J Roy Stat Soc B 59:447–461 1997a) developed semiparametric maximum likelihood estimation for two-phase studies with a case–control first phase under a logistic regression model and noted that, apart for the overall intercept term, it was the same as the semiparametric estimator for two-phase studies with a prospective first phase developed in Scott and Wild (Biometrica 84:57–71 1997). In this paper we extend the Breslow–Holubkov result to general binary regression models and show that it has a very simple relationship with its prospective first-phase counterpart. We also explore why the design of the first phase only affects the intercept of a logistic model, simplify the calculation of standard errors, establish the semiparametric efficiency of the Breslow–Holubkov estimator and derive its asymptotic distribution in the general case.     

Multistage sampling for latent variable models

I consider the design of multistage sampling schemes for epidemiologic studies involving latent variable models, with surrogate measurements of the latent variables on a subset of subjects. Such models arise in various situations: when detailed exposure measurements are combined with variables that can be used to assign exposures to unmeasured subjects; when biomarkers are obtained to assess an unobserved pathophysiologic process; or when additional information is to be obtained on confounding or modifying variables. In such situations, it may be possible to stratify the subsample on data available for all subjects in the main study, such as outcomes, exposure predictors, or geographic locations. Three circumstances where analytic calculations of the optimal design are possible are considered: (i) when all variables are binary; (ii) when all are normally distributed; and (iii) when the latent variable and its measurement are normally distributed, but the outcome is binary. In each of these cases, it is often possible to considerably improve the cost efficiency of the design by appropriate selection of the sampling fractions. More complex situations arise when the data are spatially distributed: the spatial correlation can be exploited to improve exposure assignment for unmeasured locations using available measurements on neighboring locations; some approaches for informative selection of the measurement sample using location and/or exposure predictor data are considered.     

Using a mixture model for multiple imputation in the presence of outliers: the 'Healthy for life' project

Summary.  We consider the problem of obtaining population-based inference in the presence of missing data and outliers in the context of estimating the prevalence of obesity and body mass index measures from the 'Healthy for life' study. Identifying multiple outliers in a multivariate setting is problematic because of problems such as masking, in which groups of outliers inflate the covariance matrix in a fashion that prevents their identification when included, and swamping, in which outliers skew covariances in a fashion that makes non-outlying observations appear to be outliers. We develop a latent class model that assumes that each observation belongs to one of K unobserved latent classes, with each latent class having a distinct covariance matrix. We consider the latent class covariance matrix with the largest determinant to form an 'outlier class'. By separating the covariance matrix for the outliers from the covariance matrices for the remainder of the data, we avoid the problems of masking and swamping. As did Ghosh-Dastidar and Schafer, we use a multiple-imputation approach, which allows us simultaneously to conduct inference after removing cases that appear to be outliers and to promulgate uncertainty in the outlier status through the model inference. We extend the work of Ghosh-Dastidar and Schafer by embedding the outlier class in a larger mixture model, consider penalized likelihood and posterior predictive distributions to assess model choice and model fit, and develop the model in a fashion to account for the complex sample design. We also consider the repeated sampling properties of the multiple imputation removal of outliers.     

Semiparametric Bayesian classification with longitudinal markers

Summary.  We analyse data from a study involving 173 pregnant women. The data are observed values of the β human chorionic gonadotropin hormone measured during the first 80 days of gestational age, including from one up to six longitudinal responses for each woman. The main objective in this study is to predict normal versus abnormal pregnancy outcomes from data that are available at the early stages of pregnancy. We achieve the desired classification with a semiparametric hierarchical model. Specifically, we consider a Dirichlet process mixture prior for the distribution of the random effects in each group. The unknown random-effects distributions are allowed to vary across groups but are made dependent by using a design vector to select different features of a single underlying random probability measure. The resulting model is an extension of the dependent Dirichlet process model, with an additional probability model for group classification. The model is shown to perform better than an alternative model which is based on independent Dirichlet processes for the groups. Relevant posterior distributions are summarized by using Markov chain Monte Carlo methods.     

Bayesian analysis of human movement curves

Summary.  We consider the Bayesian analysis of human movement data, where the subjects perform various reaching tasks. A set of markers is placed on each subject and a system of cameras records the three-dimensional Cartesian co-ordinates of the markers during the reaching movement. It is of interest to describe the mean and variability of the curves that are traced by the markers during one reaching movement, and to identify any differences due to covariates. We propose a methodology based on a hierarchical Bayesian model for the curves. An important part of the method is to obtain identifiable features of the movement so that different curves can be compared after temporal warping. We consider four landmarks and a set of equally spaced pseudolandmarks are located in between. We demonstrate that the algorithm works well in locating the landmarks, and shape analysis techniques are used to describe the posterior distribution of the mean curve. A feature of this type of data is that some parts of the movement data may be missing—the Bayesian methodology is easily adapted to cope with this situation.     

Adaptive sampling without replacement of clusters

In a common form of adaptive cluster sampling, an initial sample of units is selected by random sampling without replacement and, whenever the observed value of the unit is sufficiently high, its neighboring units are added to the sample, with the process of adding neighbors repeated if any of the added units are also high valued. In this way, an initial selection of a high-valued unit results in the addition of the entire network of surrounding high-valued units and some low-valued “edge” units where sampling stops. Repeat selections can occur when more than one initially selected unit is in the same network or when an edge unit is shared by more than one added network. Adaptive sampling without replacement of networks avoids some of this repeat selection by sequentially selecting initial sample units only from the part of the population not already in any selected network. The design proposed in this paper carries this step further by selecting initial units only from the population, exclusive of any previously selected networks or edge units.     

我国可转换债券转股条款设计的实证研究

转股条款的灵活设计是实现可转债特定融资动因的重要途径之一,本文根据相关理论假说及其对证券条款设计的意义,设计了较为系统的实证分析框架和稳健的模型估计方法,对我国可转债的转股条款进行了较为严格意义上的实证检验。研究发现,高负债率、小规模和获取经营现金能力较差的公司明显倾向于设计较低的转股价格和较高的转换比率;信用记录较短（以上市年限代表）和收益不稳定的公司具有相同的倾向。国内可转债设计主要由财务危机假说解释,而制度性因素对条款设计具有重要影响。总体上,目前可转债的条款设计没有得到发行人的理性对待,本文就此提出了相关政策建议。