Dependence Between Two Diagnostic Tests with Copula Function Approach: A Simulation Study

The study of the dependence between two medical diagnostic tests is an important issue in health research since it can modify the diagnosis and, therefore, the decision regarding a therapeutic treatment for an individual. In many practical situations, the diagnostic procedure includes the use of two tests, with outcomes on a continuous scale. For final classification, usually there is an additional “gold standard” or reference test. Considering binary test responses, we usually assume independence between tests or a joint binary structure for dependence. In this article, we introduce a simulation study assuming two dependent dichotomized tests using two copula function dependence structures in the presence or absence of verification bias. We compare the test parameter estimators obtained under copula structure dependence with those obtained assuming binary dependence or assuming independent tests.     

Variable Selection via Regression Trees in the Presence of Irrelevant Variables

Many tree algorithms have been developed for regression problems. Although they are regarded as good algorithms, most of them suffer from loss of prediction accuracy when there are many irrelevant variables and the number of predictors exceeds the number of observations. We propose the multistep regression tree with adaptive variable selection to handle this problem. The variable selection step and the fitting step comprise the multistep method.

The multistep generalized unbiased interaction detection and estimation (GUIDE) with adaptive forward selection (fg) algorithm, as a variable selection tool, performs better than some of the well-known variable selection algorithms such as efficacy adaptive regression tube hunting (EARTH), FSR (false selection rate), LSCV (least squares cross-validation), and LASSO (least absolute shrinkage and selection operator) for the regression problem. The results based on simulation study show that fg outperforms other algorithms in terms of selection result and computation time. It generally selects the important variables correctly with relatively few irrelevant variables, which gives good prediction accuracy with less computation time.     

Robust methods in econometrics

This survey of recent developments in robust estimation and inference is directed primarily toward econometricians. It is argued that many of the techniques in common use in econometrics are highly sensitive to unverified hypotheses. Recent progress in designing alternative robust procedures is described and some prospects for future developments are discussed.     

Book Reviews

The diagnostic tools examined in this article are applicable to regressions estimated with panel data or cross-sectional data drawn from a population with grouped structure. The diagnostic tools considered include (a) tests for the existence of group effects under both fixed and random effects models, (b) checks for outlying groups, and (c) specification tests for comparing the fixed and random effects models. A group-specific counterpart to the studentized residual is introduced. The methods are illustrated using a hedonic housing price regression.     

Estimating systems of trending variables

A survey is given of some results on inference in cointegrated systems. We discuss some regression methods, and contrast them with the analysis of the vector autoregressive model. We discuss determination of cointegrating rank and estimation of parameters, as well as asymptotic inference. The problems are treated for 1(1) and for 1(2) variables.     

Understanding Canonical Correlation through the General Linear Model and Principal Components

Canonical correlation has been little used and little understood, even by otherwise sophisticated analysts. An alternative approach to canonical correlation, based on a general linear multivariate model, is presented. Properties of principal component analysis are used to help explain the method. Standard computational methods for full rank canonical correlation, techniques for canonical correlation on component scores, and canonical correlation with less than full rank are discussed. They are seen to be essentially equivalent when the model equation for canonical correlation on component scores is presented. The two approaches to less than full rank situations are equivalent in some senses, but quite different in usefulness, depending on the application. An example dataset is analyzed in detail to help demonstrate the conclusions.     

Use of the Correlation Coefficient with Normal Probability Plots

The use of the correlation coefficient is suggested as a technique for summarizing and objectively evaluating the information contained in probability plots. Goodness-of-fit tests are constructed using this technique for several commonly used plotting positions for the normal distribution. Empirical sampling methods are used to construct the null distribution for these tests, which are then compared on the basis of power against certain nonnormal alternatives. Commonly used regression tests of fit are also included in the comparisons. The results indicate that use of the plotting position p_i = (i - .375)/(n + .25) yields a competitive regression test of fit for normality.     

A Critical Look at Some Analyses of Major League Baseball Salaries

At a data analysis exposition sponsored by the Section on Statistical Graphics of the ASA in 1988, 15 groups of statisticians analyzed the same data about salaries of major league baseball players. By examining what they did, what worked, and what failed, we can begin to learn about the relative strengths and weaknesses of different approaches to analyzing data. The data are rich in difficulties. They require reexpression, contain errors and outliers, and exhibit nonlinear relationships. They thus pose a realistic challenge to the variety of data analysis techniques used. The analysis groups chose a wide range of model-fitting methods, including regression, principal components, factor analysis, time series, and CART. We thus have an effective framework for comparing these approaches so that we can learn more about them. Our examination shows that approaches commonly identified with Exploratory Data Analysis are substantially more effective at revealing the underlying patterns in the data and at building parsimonious, understandable models that fit the data well. We also find that common data displays, when applied carefully, are often sufficient for even complex analyses such as this.