Using quantile averages in matched observational studies

In two observational studies, one investigating the effects of minimum wage laws on employment and the other of the effects of exposures to lead, an estimated treatment effect's sensitivity to hidden bias is examined. The estimate uses the combined quantile averages that were introduced in 1981 by B. M. Brown as simple, efficient, robust estimates of location admitting both exact and approximate confidence intervals and significance tests. Closely related to Gastwirth's estimate and Tukey's trimean, the combined quantile average has asymptotic efficiency for normal data that is comparable with that of a 15% trimmed mean, and higher efficiency than the trimean, but it has resistance to extreme observations or breakdown comparable with that of the trimean and better than the 15% trimmed mean. Combined quantile averages provide consistent estimates of an additive treatment effect in a matched randomized experiment. Sensitivity analyses are discussed for combined quantile averages when used in a matched observational study in which treatments are not randomly assigned. In a sensitivity analysis in an observational study, subjects are assumed to differ with respect to an unobserved covariate that was not adequately controlled by the matching, so that treatments are assigned within pairs with probabilities that are unequal and unknown. The sensitivity analysis proposed here uses significance levels, point estimates and confidence intervals based on combined quantile averages and examines how these inferences change under a range of assumptions about biases due to an unobserved covariate. The procedures are applied in the studies of minimum wage laws and exposures to lead. The first example is also used to illustrate sensitivity analysis with an instrumental variable.     

Modelling Variability in the Branching Structure of Strawberry Inflorescences

The branching structure of inflorescences of the cultivated strawberry ( Fragaria × ananassa Duch.) is very variable. This paper demonstrates that some aspects of this variability are well described by a simple stochastic model of branching that has two adjustable parameters. The model is shown to provide a good fit to data from a set of almost 700 inflorescences of the cultivar Elsanta, collected over two successive years. For one parameter the maximum likelihood estimator is a moment estimator which is fully efficient even if the detailed branching structure of the inflorescences is not recorded. This parameter provides a convenient summary of branching vigour. The maximum likelihood estimator of the second parameter must be determined iteratively and can be quite inefficient unless the full branching structure is recorded. The model demonstrates that branching structure is affected by the order in which inflorescences emerge on the plant.     

A Characterization of the Normal Family of Distributions Based on the Bias of the Maximum Likelihood Estimator

This paper characterizes the family of Normal distributions within the class of exponential families of distributions, via the structure of the bias of the maximum likelihood estimator Θ _n of the canonical parameter Θ . More specifically, when E _θ ( Θ n ) – Θ = (1/ n ) Q ( Θ ) + o (1/ n ), the equality Q ( Θ ) = 0 proves to be a property of the Normal distribution only. The same conclusion is obtained for the one-dimensional case bt assuming that Q ( Θ ) is a polynomial of Θ .     

Multiple roots of estimating functions

Estimating functions can have multiple roots. In such cases, the statistician must choose among the roots to estimate the parameter. Standard asymptotic theory shows that in a wide variety of cases, there exists a unique consistent root, and that this root will lie asymptotically close to other consistent (possibly inefficient) estimators for the parameter. For this reason, attention has largely focused on the problem of selecting this root and determining its approximate asymptotic distribution. In this paper, however, we concentrate on the exact distribution of the roots as a random set. In particular, we propose the use of higher-order root intensity functions as a tool for examining the properties of the roots and determining their most problematic features. The use of root intensity functions of first and second order is illustrated by application to the score function for the Cauchy location model.     

Robust location estimation with missing data

In a missing data setting, we have a sample in which a vector of explanatory variables ${\bf x}_i$ is observed for every subject i, while scalar responses $y_i$ are missing by happenstance on some individuals. In this work we propose robust estimators of the distribution of the responses assuming missing at random (MAR) data, under a semiparametric regression model. Our approach allows the consistent estimation of any weakly continuous functional of the response's distribution. In particular, strongly consistent estimators of any continuous location functional, such as the median, L‐functionals and M‐functionals, are proposed. A robust fit for the regression model combined with the robust properties of the location functional gives rise to a robust recipe for estimating the location parameter. Robustness is quantified through the breakdown point of the proposed procedure. The asymptotic distribution of the location estimators is also derived. The proofs of the theorems are presented in Supplementary Material available online. The Canadian Journal of Statistics 41: 111–132; 2013 © 2012 Statistical Society of Canada     

Parameter selection in modified histogram estimates

A multivariate modified histogram density estimate depending on a reference density g and a partition P has been proved to have good consistency properties according to several information theoretic criteria. Given an i.i.d. sample, we show how to select automatically both g and P so that the expected L ₁ error of the corresponding selected estimate is within a given constant multiple of the best possible error plus an additive term which tends to zero under mild assumptions. Our method is inspired by the combinatorial tools developed by Devroye and Lugosi [Devroye, L. and Lugosi, G., 2001, Combinatorial Methods in Density Estimation (New York, NY: Springer–Verlag)] and it includes a wide range of reference density and partition models. Results of simulations are also presented.     

Analyzing Binomial Data in a Split-Plot Design: Classical Approach or Modern Techniques?

Modeling data that are non-normally distributed with random effects is the major challenge in analyzing binomial data in split-plot designs. Seven methods for analyzing such data using mixed, generalized linear, or generalized linear mixed models are compared for the size and power of the tests. This study shows that analyzing random effects properly is more important than adjusting the analysis for non-normality. Methods based on mixed and generalized linear mixed models hold Type I error rates better than generalized linear models. Mixed model methods tend to have higher power than generalized linear mixed models when the sample size is small.     

Income vulnerability of rural households in Bangladesh: a comparison between Bayesian and classical methods

The geographical location and the monsoon climate render Bangladesh highly vulnerable to natural hazards, deteriorating the country's socio-economic stability. This study is based on 500 randomly chosen rural households from the Household Income and Expenditure Survey [Bangladesh Bureau of Statistics, Planning Division, Ministry of Planning, Government of the People's Republic of Bangladesh, Dhaka, 2006]. The objectives are to estimate the income vulnerability of rural households and to check whether the Bayesian approaches (natural conjugate prior and non-informative prior estimates) have any superiority over the classical (feasible generalized least square (FGLS)) method. The poverty level, measured from the data, is 24%; whereas the vulnerability estimates, using FGLS, natural conjugate prior and non-informative prior are 31%, 69% and 82%, respectively. Vulnerability estimates by the Bayesian natural conjugate prior approach is found to have greater efficiency compared with FGLS and non-informative prior approaches.     

New Developments in Statistical Computing: New Bias Evaluation Features of EXPLOR—A Program for Assessing Experimental Design Properties

Longitudinal investigations play an increasingly prominent role in biomedical research. Much of the literature on specifying and fitting linear models for serial measurements uses methods based on the standard multivariate linear model. This article proposes a more flexible approach that permits specification of the expected response as an arbitrary linear function of fixed and time-varying covariates so that mean-value functions can be derived from subject matter considerations rather than methodological constraints. Three families of models for the covariance function are discussed: multivariate, autoregressive, and random effects. Illustrations demonstrate the flexibility and utility of the proposed approach to longitudinal analysis.     

On Graphing Paired Data

Techniques for graphing paired data are considered. A conventional method frequently used when reporting scientific results, particularly in medical journals, involves representing pairs of measurements by straight line segments titled at different angles related to the differences between the components of the data pairs. However when the sample size is only moderately large, this type of display can become cluttered and thus uninformative due to overlap. It is suggested that a new graph that combines features of ANOVA plots and multivalued dot charts may provide a more effective visual display of paired data. A designed experiment in data perception using simulated data provides some evidence in favor of this parallel line plot.