Hypothesis Testing Problems in an Unbalanced Longitudinal Ophthalmology Study

ABSTRACT

The analysis of clustered data in a longitudinal ophthalmology study is complicated by correlations between repeatedly measured visual outcomes of paired eyes in a participant and missing observations due to the loss of follow-up. In the present article we consider hypothesis testing problems in an ophthalmology study, where eligible eyes are randomized to two treatments (when two eyes of a participant are eligible, the paired eyes are assigned to different treatments), and vision function outcomes are repeatedly measured over time. A large sample-based nonparametric test statistic and a nonparametric Bootstrap test analog are proposed for testing an interaction effect of two factors and testing an effect of a eye-specific factor within a level of the other person-specific factor on visual function outcomes. Both test statistics allow for missing observations, correlations between repeatedly measured outcomes on individual eyes, and correlations between repeatedly measured outcomes on both eyes of each participant. A simulation study shows that these proposed test statistics maintain nominal significance levels approximately and comparable powers to each other, as well as higher powers than the naive test statistic ignoring correlations between repeated bilateral measurements of both eyes in the same person. For illustration, we apply the proposed test statistics to the changes of visual field defect score in the Advanced Glaucoma Intervention Study.     

On Sharp Jensen's Inequality and Some Unusual Applications

The purpose of this article is two-fold. First, we find it very interesting to explore a kind of notion of optimality of the customary Jensen-bound among all Jensen-type bounds. Without this result, the customary Jensen-bound stood alone simply as just another bound. The proposed notion and the associated optimality are important given that in some situations the Jensen's inequality does leave us empty handed.

When it comes to highlighting Jensen's inequality, unfortunately only a handful of nearly routine applications continues to recycle time after time. Such encounters rarely produce any excitement. This article may change that outlook given its second underlying purpose, which is to introduce a variety of unusual applications of Jensen's inequality. The collection of our important and useful applications and their derivations are new.     

Analysis of a factorial quantal response assay using inverse regression

An inverse regression approach to analyzing quantal response assays with one quanritative independent- variable and any number of qualitative independent variables is presented. A general factorial model ror LQC- inverted relationship and methods of testing hypotheses estimating qulitative Interest are developed. This naper provides a modified method of analysis which is easier to apply than previously existing methods.     

The mad estimator: when is it non-linear? applications to two-way design models

The mean absolute deviation (MAD) estimator has recently received a great deal of attention as applied to full-rank linear regression models. This paper provides a necessary and sufficient condition for the MAD estimator to be a non-linear estimator, in which case conditions for the variance of the MAD estimator to be larger or smaller than those for OLS are, in general, unknown. The non-linearity of the MAD estimator is examined for several two-way designs; in particular (1) randomized block design (2) two-way nested design (3) two-way classification with interaction and (4) partially balanced incomplete block design     

Structural properties and estimation in m|EK| 1 queue

In this paper we study the distribution of the number of customers served in a busy period in the framework of modified power series distribution introduced by Gupta (197U) and obtain the moments and probability generating function of this distribution. We also study the maximum likelihood estimation of the parameter θand the variance and the asymptotic bias of the MLE are also obtained. The minimum variance unbiased estimate of θ^ris investigated and an estimate of the probabilities is given.     

Multiplicative-interaction logit models for i×j×2 three-way tables

Multiplicative-interaction (M-I) logit models are proposed for three-way IxJx2 contingency tables where the third variable constitutes a binary response. Models are derived by assigning unknown scores to the categories and forming product interactions from them. Asymptotic results under special sampling constraints are derived for maximum likelihood estimates and the goodness-of-fit statistics. The class of models proposed in this paper are found to be useful when no obvious scores are available. An example is included.     

Asymptotic equivalence of the harrell-davis median estimator and the sample median

This paper presents an asymptotic equivalence result with a sharp rate of convergence forthe sample median and the Harrell-Davis median estimator. The consequences of this result are discussed.     

An emplrical bayes approach in estimating the parameters of the or more geometric distributions

The estimation of the parameters of two or more geometric distribuionsis considered by usinq an empirical Bayesian approach. Robbins (1983) gave empirical Bayes estimates if the number of distributions N is large, buthere we consider the cascwhore N is small. The parameters of the prior distribution areest imated by looking at maximum like lihood and momentest imation methods.