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61.
    
New drug discovery in the pediatrics has dramatically improved survival, but with long- term adverse events. This motivates the examination of adverse outcomes such as long-term toxicity in a phase IV trial. An ideal approach to monitor long-term toxicity is to systematically follow the survivors, which is generally not feasible. Instead, cross-sectional surveys are conducted in Hudson et al. (2007 Hudson , M. M. , Rai , S. N. , Nunez , C. , Merchant , T. E. , Marina , N. M. , Zalamea , N. , Cox , C. , Phipps , S. , Pompeu , R. , Rosenthal , D. ( 2007 ). Noninvasive evaluation of late anthracycline cardiac toxicity in childhood cancer survivors . J. Clin. Oncol. 25 : 36353643 .[Crossref], [PubMed], [Web of Science ®] [Google Scholar]), with one of the objectives to estimate the cumulative incidence rates along with specific interest in fixed-term (5 or 10 year) rates. We present inference procedures based on current status data to our motivating example with very interesting findings.  相似文献   
62.
    
General augmentation techniques in experimental design, such as the foldover and the semifold, have been a common practice in industrial experimentation for years. Even though these techniques are extremely effective in maintaining balance and near orthogonality, they possess disadvantages, such as the inability to decouple specific terms and inefficiency. This article aims for a sequential experimentation approach capable of overcoming the drawbacks of the general methods while maintaining some of their benefits. We focus on the development of an algorithm for sequential augmentation of fractional factorial designs resolution III. Advantages, limitations, and potential benefits of the new method are provided.  相似文献   
63.
    
This paper studies nonparametric estimation of conditional moment restrictions in which the generalized residual functions can be nonsmooth in the unknown functions of endogenous variables. This is a nonparametric nonlinear instrumental variables (IV) problem. We propose a class of penalized sieve minimum distance (PSMD) estimators, which are minimizers of a penalized empirical minimum distance criterion over a collection of sieve spaces that are dense in the infinite‐dimensional function parameter space. Some of the PSMD procedures use slowly growing finite‐dimensional sieves with flexible penalties or without any penalty; others use large dimensional sieves with lower semicompact and/or convex penalties. We establish their consistency and the convergence rates in Banach space norms (such as a sup‐norm or a root mean squared norm), allowing for possibly noncompact infinite‐dimensional parameter spaces. For both mildly and severely ill‐posed nonlinear inverse problems, our convergence rates in Hilbert space norms (such as a root mean squared norm) achieve the known minimax optimal rate for the nonparametric mean IV regression. We illustrate the theory with a nonparametric additive quantile IV regression. We present a simulation study and an empirical application of estimating nonparametric quantile IV Engel curves.  相似文献   
64.
    
This paper studies a shape‐invariant Engel curve system with endogenous total expenditure, in which the shape‐invariant specification involves a common shift parameter for each demographic group in a pooled system of nonparametric Engel curves. We focus on the identification and estimation of both the nonparametric shapes of the Engel curves and the parametric specification of the demographic scaling parameters. The identification condition relates to the bounded completeness and the estimation procedure applies the sieve minimum distance estimation of conditional moment restrictions, allowing for endogeneity. We establish a new root mean squared convergence rate for the nonparametric instrumental variable regression when the endogenous regressor could have unbounded support. Root‐n asymptotic normality and semiparametric efficiency of the parametric components are also given under a set of “low‐level” sufficient conditions. Our empirical application using the U.K. Family Expenditure Survey shows the importance of adjusting for endogeneity in terms of both the nonparametric curvatures and the demographic parameters of systems of Engel curves.  相似文献   
65.
    
This paper provides a first order asymptotic theory for generalized method of moments (GMM) estimators when the number of moment conditions is allowed to increase with the sample size and the moment conditions may be weak. Examples in which these asymptotics are relevant include instrumental variable (IV) estimation with many (possibly weak or uninformed) instruments and some panel data models that cover moderate time spans and have correspondingly large numbers of instruments. Under certain regularity conditions, the GMM estimators are shown to converge in probability but not necessarily to the true parameter, and conditions for consistent GMM estimation are given. A general framework for the GMM limit distribution theory is developed based on epiconvergence methods. Some illustrations are provided, including consistent GMM estimation of a panel model with time varying individual effects, consistent limited information maximum likelihood estimation as a continuously updated GMM estimator, and consistent IV structural estimation using large numbers of weak or irrelevant instruments. Some simulations are reported.  相似文献   
66.
67.
马彪等 《统计研究》2021,38(9):101-113
农产品电商作为数字经济直接催生的新业态,为农民增收提供了新渠道。本文以家庭农场为研究对象,基于全国农村固定观察点新型农业经营主体发展指数专项调查的微观数据,对农产品电商的增收效应进行了实证检验。研究结果表明,农产品电商对家庭农场农业经营性收入的提高有明显的促进作用,但农产品电商的增收效应具有异质性。条件分位数处理效应的估计结果显示,农产品电商对中低收入水平家庭农场的增收效果要明显好于中高收入水平的家庭农场,更进一步的中介效应检验证实了自有品牌和产品认证在农产品电商增收效应中的部分中介作用。未来应该提升农村电商的配套服务水平,努力为农产品电商营造良好的电商氛围,以期更好地发挥农产品电商的增收效应。  相似文献   
68.
A series of weakly resolvable search designs for the pn factorial experiment is given for which the mean and all main effects are estimable in the presence of any number of two-factor interactions and for which any combination of three or fewer pairs of factors that interact may be detected. The designs have N = p(p–1)n+p runs except in one case where additional runs are required for detection and one case where (p?1)2 additional runs are needed to estimate all (p–1)2 degrees of freedom for each pair of detected interactions. The detection procedure is simple enough that computations can be carried out with hand calculations.  相似文献   
69.
《古田会议决议》蕴含着较为丰富的平等思想,主要表现在经济平等思想、政治平等思想和生活平等思想三个方面,而且每一方面都对当前更好地贯彻落实社会主义核心价值观具有重大的借鉴意义。  相似文献   
70.
Generalized aberration (GA) is one of the most frequently used criteria to quantify the suitability of an orthogonal array (OA) to be used as an experimental design. The two main motivations for GA are that it quantifies bias in a main-effects only model and that it is a good surrogate for estimation efficiencies of models with all the main effects and some two-factor interaction components. We demonstrate that these motivations are not appropriate for three-level OAs of strength 3 and we propose a direct classification with other criteria instead. To illustrate, we classified complete series of three-level strength-3 OAs with 27, 54 and 81 runs using the GA criterion, the rank of the matrix with two-factor interaction contrasts, the estimation efficiency of two-factor interactions, the projection estimation capacity, and a new model robustness criterion. For all of the series, we provide a list of admissible designs according to these criteria.  相似文献   
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