Correlation of Noncancer Benchmark Doses in Short‐ and Long‐Term Rodent Bioassays

This study investigated whether, in the absence of chronic noncancer toxicity data, short‐term noncancer toxicity data can be used to predict chronic toxicity effect levels by focusing on the dose–response relationship instead of a critical effect. Data from National Toxicology Program (NTP) technical reports have been extracted and modeled using the Environmental Protection Agency's Benchmark Dose Software. Best‐fit, minimum benchmark dose (BMD), and benchmark dose lower limits (BMDLs) have been modeled for all NTP pathologist identified significant nonneoplastic lesions, final mean body weight, and mean organ weight of 41 chemicals tested by NTP between 2000 and 2012. Models were then developed at the chemical level using orthogonal regression techniques to predict chronic (two years) noncancer health effect levels using the results of the short‐term (three months) toxicity data. The findings indicate that short‐term animal studies may reasonably provide a quantitative estimate of a chronic BMD or BMDL. This can allow for faster development of human health toxicity values for risk assessment for chemicals that lack chronic toxicity data.     

The hierarchical model for load balancing on two machines

Following previous work, we consider the hierarchical load balancing model on two machines of possibly different speeds. We first focus on maximizing the minimum machine load and show that no competitive algorithm exists for this problem. We overcome this barrier in two ways, both related to previously known models. The first one is fractional assignment, where each job can be arbitrarily split between the machines. The second one is a semi-online model where the sum of jobs is known in advance. We design algorithms of best possible competitive ratios for both these cases. Furthermore, we show that the combination of the two models leads to the existence of an optimal algorithm (i.e., an algorithm of competitive ratio 1). This algorithm is clearly optimal for the makespan minimization problem as well. For the latter problem, we consider the fractional assignment model and design an algorithm of best possible competitive ratio for it. This work was submitted as the M.Sc. thesis of the first author.     

Restricted likelihood ratio lack-of-fit tests using mixed spline models

Summary.  Penalized regression spline models afford a simple mixed model representation in which variance components control the degree of non-linearity in the smooth function estimates. This motivates the study of lack-of-fit tests based on the restricted maximum likelihood ratio statistic which tests whether variance components are 0 against the alternative of taking on positive values. For this one-sided testing problem a further complication is that the variance component belongs to the boundary of the parameter space under the null hypothesis. Conditions are obtained on the design of the regression spline models under which asymptotic distribution theory applies, and finite sample approximations to the asymptotic distribution are provided. Test statistics are studied for simple as well as multiple-regression models.     

Ordered Tests for Right–Censored Survival Data

In comparative clinical trials or animal carcinogenesis studies, the effect of increasing dose levels of an agent or an increasing number of additional modalities are frequently evaluated on the prolonged survival time of patients with a particular disease. It is of particular interest to test the ordered alternative that a treatment level increase leads to better survival. This paper considers an ordered test based on the two–sample weighted Kaplan–Meier statistics (Pepe & Fleming, 1989, 1991). It evaluates asymptotic relative efficiencies of the proposed ordered weighted Kaplan–Meier test, the competing ordered weighted logrank test (Liu et al., 1993) and modified ordered logrank test (Liu & Tsai, 1999) under Lehmann alternatives, for various piecewise exponential survival distributions. Finally, it demonstrates the proposed test on an appropriate dataset.     

四川能源现状及其能源结构发展选择——从中国太阳能第一楼谈起

中国太阳能第一楼试运行的成功是我国对传统能源消费结构开始变革的标志:用清洁能源替代传统能源推动经济的可持续发展。四川的能源资源品种齐全,除了丰富的水力能资源外,煤炭、天然气、泥炭等常规能源以及风能、太阳能等新能源都有一定数量。但长期以来四川一直以煤炭能源消费占主导,使本来应该发挥优势的水能和天然气资源没有得到有效开发。第一楼自给性清洁能源选择的重要启示就是要充分结合区域资源优势、高效利用能源尤其是清洁能源。     

A family of power‐divergence diagnostics for goodness‐of‐fit

The author extends to the Bayesian nonparametric context the multinomial goodness‐of‐fit tests due to Cressie & Read (1984). Her approach is suitable when the model of interest is a discrete distribution. She provides an explicit form for the tests, which are based on power‐divergence measures between a prior Dirichlet process that is highly concentrated around the model of interest and the corresponding posterior Dirichlet process. In addition to providing interesting special cases and useful approximations, she discusses calibration and the choice of test through examples.     

A nonparametric test for interaction in two‐way layouts

The authors present a new nonparametric approach to test for interaction in two‐way layouts. Based on the concept of composite linear rank statistics, they combine the correlated row and column ranking information to construct the test statistic. They determine the limiting distributions of the proposed test statistic under the null hypothesis and Pitman alternatives. They also propose consistent estimators for the limiting covariance matrices associated with the test. They illustrate the application of their test in practical settings using a microarray data set.     

Modified Restricted Almost Unbiased Liu Estimator in Linear Regression Model

In this article we introduce a modified restricted almost unbiased Liu estimator in linear regression model which satisfies the linear restrictions. The mean squared error matrix (MSEM) of the proposed estimator is derived and compared with the corresponding competitors in literature. Finally, a numerical example and a Monte Carlo simulation are given to illustrate some of the theoretical results.     

傈僳族的跨界迁徙与生计方式变迁

傈僳族是我国西南边疆迁徙活动较为频繁的跨界民族之一。文章运用历史文献和田野考察资料,以在中缅北界地区生活的傈僳族为例,力求在社会变迁的历史和现实中对其生计方式的转换进行讨论,将跨界迁徙和游动与生计方式变迁联系起来,强调族际交往、族群关系与民族认同对生计方式变迁造成的影响,兼而讨论生计方式变迁与国家管理模式的关联性。     

Truncated linear estimation of a bounded multivariate normal mean

We consider the problem of estimating the mean θ$\theta$ of an _Np(θ,_Ip)${\mathrm{N}}_{\mathrm{p}}(\theta ,I_p)$ distribution with squared error loss ∥δ−θ∥²$\parallel \delta -\theta {\parallel }^2$ and under the constraint ∥θ∥≤m$\parallel \theta \parallel \le m$, for some constant m>0$m>0$. Using Stein's identity to obtain unbiased estimates of risk, Karlin's sign change arguments, and conditional risk analysis, we compare the risk performance of truncated linear estimators with that of the maximum likelihood estimator _δmle${\delta }_{\mathrm{mle}}$. We obtain for fixed (m,p)$(m,p)$ sufficient conditions for dominance. An asymptotic framework is developed, where we demonstrate that the truncated linear minimax estimator dominates _δmle${\delta }_{\mathrm{mle}}$, and where we obtain simple and accurate measures of relative improvement in risk. Numerical evaluations illustrate the effectiveness of the asymptotic framework for approximating the risks for moderate or large values of p.