Sample Size Calculation for the Therapeutic Equivalence Problem

A method is proposed for the sample size calculation in the case of therapeutic equivalence of two pharmaceuticals, when the decision is based on post-treatment differences and the post-treatment values are dependent on the pretreatment ones. When the correlation coefficient is large (over 0.7), it is shown that sample size calculation (and the corresponding hypothesis test) based on the sample statistic formed by the mean difference of the post–pre differences of each group has smaller variance and hence leads to smaller sample sizes.     

New Goodness-of-Fit Tests Based on Sample Quantiles

In this article power divergences statistics based on sample quantiles are transformed in order to introduce new goodness-of-fit tests. Quantiles of the distribution of proposed statistics are calculated under uniformity, normality, and exponentiality. Several power comparisons are performed to show that the new tests are generally more powerful than the original ones.     

Accuracy Analysis of the Percentile Method for Estimating Non Normal Manufacturing Quality

We consider asymmetric kernel estimates based on grouped data. We propose an iterated scheme for constructing such an estimator and apply an iterated smoothed bootstrap approach for bandwidth selection. We compare our approach with competing methods in estimating actuarial loss models using both simulations and data studies. The simulation results show that with this new method, the estimated density from grouped data matches the true density more closely than with competing approaches.     

A comparison of three methods of estimating the logistic regression coefficients

A Sampling experiment performed using data collected for a large clinical trial shows that the discriminant function estimates of the logistic regression coefficients for discrete variables may be severely biased. The simulations show that the mixed variable location model coefficient estimates have bias which is of the same magnitude as the bias in the coefficient estimates obtained using conditional maximum likelihood estimates but require about one-tenth of the computer time.     

Computational algorithms for the factor model

Algorithms for computing the maximum likelihood estimators and the estimated covariance matrix of the estimators of the factor model are derived. The algorithms are particularly suitable for large matrices and for samples that give zero estimates of some error variances. A method of constructing estimators for reduced models is presented. The algorithms can also be used for the multivariate errors-in-variables model with known error covariance matrix.     

A robust procedure for testing an assumed value of the population correlation coefficient

For testing that the population correlations coefficientp Q, Tiku and Balakrishnan1986) developed a robust test. This test is extended here to situcitions where one wants to test that p p , p being a specified non-zero value of p. o o     

Small sample properties of parameter estimation in the dirichlet distribution

A numerically feasible algorithm is proposed for maximum likelihood estimation of the parameters of the Dirichlet distribution. The performance of the proposed method is compared with the method of moments using bias ratio and squared errors by Monte Carlo simulation. For these criteria, it is found that even in small samples maximum likelihood estimation has advantages over the method of moments.     

Efficient estimators for the good family

We consider the problem of estimating the two parameters of the discrete Good distribution. We first show that the sufficient statistics for the parameters are the arithmetic and the geometric means. The maximum likelihood estimators (MLE's) of the parameters are obtained by solving numerically a system of equations involving the Lerch zeta function and the sufficient statistics. We find an expression for the asymptotic variance-covariance matrix of the MLE's, which can be evaluated numerically. We show that the probability mass function satisfies a simple recurrence equation linear in the two parameters, and propose the quadratic distance estimator (QDE) which can be computed with an ineratively reweighted least-squares algorithm. the QDE is easy to calculate and admits a simple expression for its asymptotic variance-covariance matrix. We compute this matrix for the MLE's and the QDE for various values of the parameters and see that the QDE has very high asymptotic efficiency. Finally, we present a numerical example.     

Inference in log-alpha-power and log-skew-normal multivariate models

ABSTRACT

Random vectors with positive components are common in many applied fields, for example, in meteorology, when daily precipitation is measured through a region Marchenko and Genton (2010 Marchenko, Y., Genton, M. (2010). Multivariate log-skew-elliptical distributions with applications to precipitation data. Environmetrics 21:318–340.[Crossref], [Web of Science ®] , [Google Scholar]). Frequently, the log-normal multivariate distribution is used for modeling this type of data. This modeling approach is not appropriate for data with high asymmetry or kurtosis. Consequently, more flexible multivariate distributions than the log-normal multivariate are required. As an alternative to this distribution, we propose the log-alpha-power multivariate and log-skew-normal multivariate models. The first model is an extension for positive data of the fractional order statistics model Durrans (1992 Durrans, S. (1992). Distributions of fractional order statistics in hydrology. Water Resour. Res. 28:1649–1655.[Crossref], [Web of Science ®] , [Google Scholar]). The second one is an extension of the log-skew-normal model studied by Mateu-Figueras and Pawlowsky-Glahn (2007 Mateu-Figueras, G., Pawlowsky-Glahn, V. (2007). The skew-normal distribution on the simplex. Commun. Stat.-Theory Methods 36:1787–1802.[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]). We study parameter estimation for these models by means of pseudo-likelihood and maximum likelihood methods. We illustrate the proposal analyzing a real dataset.