Block and Basu bivariate lifetime distribution in the presence of cure fraction

This paper presents estimates for the parameters included in the Block and Basu bivariate lifetime distributions in the presence of covariates and cure fraction, applied to analyze survival data when some individuals may never experience the event of interest and two lifetimes are associated with each unit. A Bayesian procedure is used to get point and confidence intervals for the unknown parameters. Posterior summaries of interest are obtained using standard Markov Chain Monte Carlo methods in rjags package for R software. An illustration of the proposed methodology is given for a Diabetic Retinopathy Study data set.     

A longitudinal analysis of infant and senescent mortality using mixture models

We construct a mixture distribution including infant, exogenous and Gompertzian/non-Gompertzian senescent mortality. Using mortality data from Swedish females 1751–, we show that this outperforms models without these features, and compare its trends in cohort and period mortality over time. We find an almost complete disappearance of exogenous mortality within the last century of period mortality, with cohort mortality approaching the same limits. Both Gompertzian and non-Gompertzian senescent mortality are consistently present, with the estimated balance between them oscillating constantly. While the parameters of the latter appear to be trending over time, the parameters of the former do not.     

On a bounded bimodal two-sided distribution fitted to the Old-Faithful geyser data

In this paper, we shall develop a novel family of bimodal univariate distributions (also allowing for unimodal shapes) and demonstrate its use utilizing the well-known and almost classical data set involving durations and waiting times of eruptions of the Old-Faithful geyser in Yellowstone park. Specifically, we shall analyze the Old-Faithful data set with 272 data points provided in Dekking et al. [3]. In the process, we develop a bivariate distribution using a copula technique and compare its fit to a mixture of bivariate normal distributions also fitted to the same bivariate data set. We believe the fit-analysis and comparison is primarily illustrative from an educational perspective for distribution theory modelers, since in the process a variety of statistical techniques are demonstrated. We do not claim one model as preferred over the other.     

Multivariate Kendall's tau for change‐point detection in copulas

Statistical procedures for the detection of a change in the dependence structure of a series of multivariate observations are studied in this work. The test statistics that are proposed are $L_1$ , $L_2$ , and $L_{\infty }$ distances computed from vectors of differences of Kendall's tau; two multivariate extensions of Kendall's measure of association are used. Since the distributions of these statistics under the null hypothesis of no change depend on the unknown underlying copula of the vectors, a procedure based on the multiplier central limit theorem is used for the computation of p‐values; the method is shown to be valid both asymptotically and for moderate sample sizes. Alternative versions of the tests that take into account possible breakpoints in the marginal distributions are also investigated. Monte Carlo simulations show that the tests are powerful under many scenarios of change‐point. In addition, two estimators of the time of change are proposed and their efficiency is carefully studied. The methodologies are illustrated on simulated series from the Canadian Regional Climate Model. The Canadian Journal of Statistics 41: 65–82; 2013 © 2012 Statistical Society of Canada     

A likelihood ratio test for goodness‐of‐fit of recessive and dominant models for case–control studies

Testing goodness‐of‐fit of commonly used genetic models is of critical importance in many applications including association studies and testing for departure from Hardy–Weinberg equilibrium. Case–control design has become widely used in population genetics and genetic epidemiology, thus it is of interest to develop powerful goodness‐of‐fit tests for genetic models using case–control data. This paper develops a likelihood ratio test (LRT) for testing recessive and dominant models for case–control studies. The LRT statistic has a closed‐form formula with a simple $\chi^{2}(1)$ null asymptotic distribution, thus its implementation is easy even for genome‐wide association studies. Moreover, it has the same power and optimality as when the disease prevalence is known in the population. The Canadian Journal of Statistics 41: 341–352; 2013 © 2013 Statistical Society of Canada     

Forecasting Multivariate Road Traffic Flows Using Bayesian Dynamic Graphical Models,Splines and Other Traffic Variables

Traffic flow data are routinely collected for many networks worldwide. These invariably large data sets can be used as part of a traffic management system, for which good traffic flow forecasting models are crucial. The linear multiregression dynamic model (LMDM) has been shown to be promising for forecasting flows, accommodating multivariate flow time series, while being a computationally simple model to use. While statistical flow forecasting models usually base their forecasts on flow data alone, data for other traffic variables are also routinely collected. This paper shows how cubic splines can be used to incorporate extra variables into the LMDM in order to enhance flow forecasts. Cubic splines are also introduced into the LMDM to parsimoniously accommodate the daily cycle exhibited by traffic flows. The proposed methodology allows the LMDM to provide more accurate forecasts when forecasting flows in a real high‐dimensional traffic data set. The resulting extended LMDM can deal with some important traffic modelling issues not usually considered in flow forecasting models. Additionally, the model can be implemented in a real‐time environment, a crucial requirement for traffic management systems designed to support decisions and actions to alleviate congestion and keep traffic flowing.     

A Copula‐Based Non‐parametric Measure of Regression Dependence

Abstract. This article presents a framework for comparing bivariate distributions according to their degree of regression dependence. We introduce the general concept of a regression dependence order (RDO). In addition, we define a new non‐parametric measure of regression dependence and study its properties. Besides being monotone in the new RDOs, the measure takes on its extreme values precisely at independence and almost sure functional dependence, respectively. A consistent non‐parametric estimator of the new measure is constructed and its asymptotic properties are investigated. Finally, the finite sample properties of the estimate are studied by means of a small simulation study.     

Maximum Likelihood Estimation for Stochastic Differential Equations with Random Effects

Abstract. We consider N independent stochastic processes (X _i (t), t ∈ [0,T _i ]), i=1,…, N, defined by a stochastic differential equation with drift term depending on a random variable φ _i . The distribution of the random effect φ _i depends on unknown parameters which are to be estimated from the continuous observation of the processes X_i. We give the expression of the exact likelihood. When the drift term depends linearly on the random effect φ _i and φ _i has Gaussian distribution, an explicit formula for the likelihood is obtained. We prove that the maximum likelihood estimator is consistent and asymptotically Gaussian, when T _i =T for all i and N tends to infinity. We discuss the case of discrete observations. Estimators are computed on simulated data for several models and show good performances even when the length time interval of observations is not very large.     

Flexible Copula Density Estimation with Penalized Hierarchical B‐splines

The paper introduces a new method for flexible spline fitting for copula density estimation. Spline coefficients are penalized to achieve a smooth fit. To weaken the curse of dimensionality, instead of a full tensor spline basis, a reduced tensor product based on so called sparse grids (Notes Numer. Fluid Mech. Multidiscip. Des., 31, 1991, 241‐251) is used. To achieve uniform margins of the copula density, linear constraints are placed on the spline coefficients, and quadratic programming is used to fit the model. Simulations and practical examples accompany the presentation.