Assessing accuracy of a continuous screening test in the presence of verification bias

Summary.  In studies to assess the accuracy of a screening test, often definitive disease assessment is too invasive or expensive to be ascertained on all the study subjects. Although it may be more ethical or cost effective to ascertain the true disease status with a higher rate in study subjects where the screening test or additional information is suggestive of disease, estimates of accuracy can be biased in a study with such a design. This bias is known as verification bias. Verification bias correction methods that accommodate screening tests with binary or ordinal responses have been developed; however, no verification bias correction methods exist for tests with continuous results. We propose and compare imputation and reweighting bias-corrected estimators of true and false positive rates, receiver operating characteristic curves and area under the receiver operating characteristic curve for continuous tests. Distribution theory and simulation studies are used to compare the proposed estimators with respect to bias, relative efficiency and robustness to model misspecification. The bias correction estimators proposed are applied to data from a study of screening tests for neonatal hearing loss.     

论政治语言的结构

分析和研究政治语言的系统结构及结构要素之间的相互关系 ,是研究政治语言的重要内容 ,有利于更好地认识和把握政治语言。政治语言结构是一种特殊的层级系统 ,其要素包括符号、符号系统、符码、文本、语境和话语。政治语言结构的要素之间相互作用、相互关联 ,共同构成了政治语言的系统 ,并以其特有的方式表达政治意义 ,服务于政治活动     

两相交流伺服电机动态性能的研究

对于两相交流电机的速度伺服系统,分析在幅值控制时系统的机械特性与调节特性,提出了影响两相交流伺服电机动态性能的因素是系统的机械时间常数及增益系数的变化。为了防止因机械时间常数及增益系数的变化而引起的动态特性变差,采用一种简易跟随模型参考自适应控制方法,通过模型与自适应机构的调节作用,改善两相交流伺服电机系统的动态特性和控制精度。计算机仿真结果表明,电机的动态持性良好。     

网络环境下的学习模式探索

教育模式是教育观念、教育思想、教与学理论的集中体现,网络的出现为学习者提供了适应个性化需求的自主学习的机会,建立满足不同学生需要的网络学习模式,是网络教学的当务之急。     

福建省耕地流向及其与经济发展的关系

土地利用数量的净变化是土地双向变化的结果。在单一土地利用类型动态度模型基础上利用单一土地利用动态变化辅助方法:列表清单法和单一土地利用动态度双向模型,对福建省及各设区市耕地流向进行分析。并在此基础上,研究了福建省耕地的减少与经济发展的关系,提出福建省耕地保护的措施。     

"生态旅游"概念探微

选取国外 44个生态旅游定义作为研究对象 ,通过确认关键词、对关键词进行聚类分析 ,将定义内容归纳为 6大类 11组分 ,进而构建生态旅游概念模型。在检验模型理论上的可靠性和实践上的适应性后 ,依据模型提出自己的生态旅游定义     

基于马尔可夫链的产品市场保有量预测模型

售后服务机构为了准确地准备库存,都需要预测产品的市场保有量。基于马尔可夫链建立的状态概率矩阵模型,与抽样调查、时间序列法、回归分析法等方法相比,更能准确预测市场产品保有量。与传统产品相比较,更新换代速度快的电子产品,要预测其市场保有量,更需要利用状态概率矩阵模型。     

建筑节能激励政策的非对称博弈分析

本文探讨了建筑节能领域中政府与房地产商群体之间的非对称博弈问题,分析了该博弈所具有的模仿者动态模型、斯坦克尔伯格模型的特点,并构造了两者关于建筑节能激励政策的非对称博弈模型,最后对双方分别提出了博弈策略建议。     

客运专线运营对区域经济的影响

铁路客运专线的运营将提高干线的客货运输能力,降低社会运输总成本,带动高新产业发展,节约旅行时间,带动第三产业的发展等.本文建立了数学模型,以秦沈客运专线为例进行了定量分析,为客运专线的规划提供参考依据.     

Influence diagnostics and outlier tests for semiparametric mixed models

Summary. Semiparametric mixed models are useful in biometric and econometric applications, especially for longitudinal data. Maximum penalized likelihood estimators (MPLEs) have been shown to work well by Zhang and co-workers for both linear coefficients and nonparametric functions. This paper considers the role of influence diagnostics in the MPLE by extending the case deletion and subject deletion analysis of linear models to accommodate the inclusion of a nonparametric component. We focus on influence measures for the fixed effects and provide formulae that are analogous to those for simpler models and readily computable with the MPLE algorithm. We also establish an equivalence between the case or subject deletion model and a mean shift outlier model from which we derive tests for outliers. The influence diagnostics proposed are illustrated through a longitudinal hormone study on progesterone and a simulated example.