A Discussion of Permutation Tests Conditional to Observed Responses in Unreplicated 2 M Full Factorial Designs

ABSTRACT

In this article we present a new solution to test for effects in unreplicated two-level factorial designs. The proposed test statistic, in case the error components are normally distributed, follows an F random variable, though our attention is on its nonparametric permutation version. The proposed procedure does not require any transformation of data such as residualization and it is exact for each effect and distribution-free. Our main aim is to discuss a permutation solution conditional to the original vector of responses. We give two versions of the same nonparametric testing procedure in order to control both the individual error rate and the experiment-wise error rate. A power comparison with Loughin and Noble's test is provided in the case of a unreplicated 2⁴ full factorial design.     

Hypothesis Testing Problems in an Unbalanced Longitudinal Ophthalmology Study

ABSTRACT

The analysis of clustered data in a longitudinal ophthalmology study is complicated by correlations between repeatedly measured visual outcomes of paired eyes in a participant and missing observations due to the loss of follow-up. In the present article we consider hypothesis testing problems in an ophthalmology study, where eligible eyes are randomized to two treatments (when two eyes of a participant are eligible, the paired eyes are assigned to different treatments), and vision function outcomes are repeatedly measured over time. A large sample-based nonparametric test statistic and a nonparametric Bootstrap test analog are proposed for testing an interaction effect of two factors and testing an effect of a eye-specific factor within a level of the other person-specific factor on visual function outcomes. Both test statistics allow for missing observations, correlations between repeatedly measured outcomes on individual eyes, and correlations between repeatedly measured outcomes on both eyes of each participant. A simulation study shows that these proposed test statistics maintain nominal significance levels approximately and comparable powers to each other, as well as higher powers than the naive test statistic ignoring correlations between repeated bilateral measurements of both eyes in the same person. For illustration, we apply the proposed test statistics to the changes of visual field defect score in the Advanced Glaucoma Intervention Study.     

The MLE of Geometric Parameter for a Geometric Process

In this article, we provide the MLE of the ratio parameter of a geometric process and discuss its consistency and asymptotic normality.     

Admissibility of Test Procedures for Linear Hypotheses in General Linear Model

This article shows that an F-test procedure is admissible for testing a linear hypothesis concerning one of the split mean vectors in a general linear model and an F-test procedure is also admissible for testing a linear hypothesis concerning another of the split mean vectors in the same model. These results are proved by showing that the critical functions of the tests are unique Bayes procedures with respect to proper prior distributions set in common for the null hypotheses and for the alternative ones, respectively.     

Marshall–Olkin Extended Lomax Distribution and Its Application to Censored Data

The problem of making statistical inference about θ =P(X > Y) has been under great investigation in the literature using simple random sampling (SRS) data. This problem arises naturally in the area of reliability for a system with strength X and stress Y. In this study, we will consider making statistical inference about θ using ranked set sampling (RSS) data. Several estimators are proposed to estimate θ using RSS. The properties of these estimators are investigated and compared with known estimators based on simple random sample (SRS) data. The proposed estimators based on RSS dominate those based on SRS. A motivated example using real data set is given to illustrate the computation of the newly suggested estimators.     

Bayesian Analysis in Regression Models Using Pseudo-Likelihoods

This article deals with the issue of using a suitable pseudo-likelihood, instead of an integrated likelihood, when performing Bayesian inference about a scalar parameter of interest in the presence of nuisance parameters. The proposed approach has the advantages of avoiding the elicitation on the nuisance parameters and the computation of multidimensional integrals. Moreover, it is particularly useful when it is difficult, or even impractical, to write the full likelihood function.

We focus on Bayesian inference about a scalar regression coefficient in various regression models. First, in the context of non-normal regression-scale models, we give a theroetical result showing that there is no loss of information about the parameter of interest when using a posterior distribution derived from a pseudo-likelihood instead of the correct posterior distribution. Second, we present non trivial applications with high-dimensional, or even infinite-dimensional, nuisance parameters in the context of nonlinear normal heteroscedastic regression models, and of models for binary outcomes and count data, accounting also for possibile overdispersion. In all these situtations, we show that non Bayesian methods for eliminating nuisance parameters can be usefully incorporated into a one-parameter Bayesian analysis.     

A New Approach for Testing Periodicity

This article describes testing for periodicity in the presence of FD processes. We propose two approaches for testing the periodicity based on Fisher's test. The first one is performed using the periodogram which has been divided into different parts. The second one is based on the discrete wavelet transform. Properties of the tests are illustrated by means of Monte Carlo simulations.     

A generalization of mosteller's test

A generalization of Mosteller's test for slippage of the location parameter is proposed. The distribution of the test statistic under the null hypothesis is obtained and the power of the test is compared with that of Mosteller's test     

On gart's test for interaction of second order

Gart (1972) ottered a Statistic on testing the hypothesis of no second-order interaction in a 2×s×t contingency table. The statistic was tn be used as an asymptotic chi-square with (s-1) (t-1) degrees of freedom. We show that this statistic suiters from the drawback that unless certain side conditions hold, the statistic would reject the null hypothesis with probability approaching one asymptotically even in the null case. Hence the statistic is not strictly valid for the hypothesis for which it was intended.