Exact Likelihood Equations for Autoregression Models with Multivariate Elliptically Contoured Distributions

Abstract

The multivariate elliptically contoured distributions provide a viable framework for modeling time-series data. It includes the multivariate normal, power exponential, t, and Cauchy distributions as special cases. For multivariate elliptically contoured autoregressive models, we derive the exact likelihood equations for the model parameters. They are closely related to the Yule-Walker equations and involve simple function of the data. The maximum likelihood estimators are obtained by alternately solving two linear systems and illustrated using the simulation data.     

A Multivariate Synthetic Control Chart for Monitoring the Process Mean Vector of Skewed Populations Using Weighted Standard Deviations

This article proposes a multivariate synthetic control chart for skewed populations based on the weighted standard deviation method. The proposed chart incorporates the weighted standard deviation method into the standard multivariate synthetic control chart. The standard multivariate synthetic chart consists of the Hotelling's T ² chart and the conforming run length chart. The weighted standard deviation method adjusts the variance–covariance matrix of the quality characteristics and approximates the probability density function using several multivariate normal distributions. The proposed chart reduces to the standard multivariate synthetic chart when the underlying distribution is symmetric. In general, the simulation results show that the proposed chart performs better than the existing multivariate charts for skewed populations and the standard T ² chart, in terms of false alarm rates as well as moderate and large mean shift detection rates based on the various degrees of skewnesses.     

Testing Equality of Mean Vectors in Two Sample Problem with Missing Data

Finding the influence of traffic accident on the road is helpful to analyze the characteristics of traffic flow, and take reasonable and effective control measures. Here, the detrended fluctuation analysis method is applied to investigate the complexity of time series in mixed traffic flow with a blockage induced by an accident. As a parameter to depict the long-term evolutionary behavior of the time series in traffic flow, the scaling exponent is analyzed. According to the scaling exponent, it is shown that the traffic flow time series can display long-range correlation characteristics, short-range correlation characteristics, and non-power-law relation in the long-range correlation characteristics, which is strongly dependent on the entering probability of vehicle, the ratio of slow vehicle and the blockage duration time.     

Dirichlet Processes in Nonlinear Mixed Effects Models

In this article, we use two efficient approaches to deal with the difficulty in computing the intractable integrals when implementing Gibbs sampling in the nonlinear mixed effects model (NLMM) based on Dirichlet processes (DP). In the first approach, we compute the Laplace's approximation to the integral for its high accuracy, low cost, and ease of implementation. The second approach uses the no-gaps algorithm of MacEachern and Müller (1998 MacEachern , S. , Müller , P. ( 1998 ). Estimating mixtures of Dirichlet process models . Journal of Computational and Graphical Statistics 7 : 223 – 238 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) to perform Gibbs sampling without evaluating the difficult integral. We apply both approaches to real problems and simulations. Results show that both approaches perform well in density estimation and prediction and are superior to the parametric analysis in that they can detect important model features, such as skewness, long tails, and multimodality, whereas the parametric analysis cannot.     

Determining Optimal Number of Samples for Constructing Multivariate Control Charts

Normally, an average run length (ARL) is used as a measure for evaluating the detecting performance of a multivariate control chart. This has a direct impact on the false alarm cost in Phase II. In this article, we first conduct a simulation study to calculate both in-control and out-of-control ARLs under various combinations of process shifts and number of samples. Then, a trade-off analysis between sampling inspection and false alarm costs is performed. Both the simulation results and trade-off analysis suggest that the optimal number of samples for constructing a multivariate control chart in Phase I can be determined.     

Infinite Variation Tempered Stable Ornstein–Uhlenbeck Processes with Discrete Observations

We investigate transition law between consecutive observations of Ornstein–Uhlenbeck processes of infinite variation with tempered stable stationary distribution. Thanks to the Markov autoregressive structure, the transition law can be written in the exact sense as a convolution of three random components; a compound Poisson distribution and two independent tempered stable distributions, one with stability index in (0, 1) and the other with index in (1, 2). We discuss simulation techniques for those three random elements. With the exact transition law and proposed simulation techniques, sample paths simulation proves significantly more efficient, relative to the known approximative technique based on infinite shot noise series representation of tempered stable Lévy processes.     

Dependence Between Two Diagnostic Tests with Copula Function Approach: A Simulation Study

The study of the dependence between two medical diagnostic tests is an important issue in health research since it can modify the diagnosis and, therefore, the decision regarding a therapeutic treatment for an individual. In many practical situations, the diagnostic procedure includes the use of two tests, with outcomes on a continuous scale. For final classification, usually there is an additional “gold standard” or reference test. Considering binary test responses, we usually assume independence between tests or a joint binary structure for dependence. In this article, we introduce a simulation study assuming two dependent dichotomized tests using two copula function dependence structures in the presence or absence of verification bias. We compare the test parameter estimators obtained under copula structure dependence with those obtained assuming binary dependence or assuming independent tests.     

The Effect of Methods for Handling Missing Values on the Performance of the MEWMA Control Chart

This article is concerned with the effect of the methods for handling missing values in multivariate control charts. We discuss the complete case, mean substitution, regression, stochastic regression, and the expectation–maximization algorithm methods for handling missing values. Estimates of mean vector and variance–covariance matrix from the treated data set are used to build the multivariate exponentially weighted moving average (MEWMA) control chart. Based on a Monte Carlo simulation study, the performance of each of the five methods is investigated in terms of its ability to obtain the nominal in-control and out-of-control average run length (ARL). We consider three sample sizes, five levels of the percentage of missing values, and three types of variable numbers. Our simulation results show that imputation methods produce better performance than case deletion methods. The regression-based imputation methods have the best overall performance among all the competing methods.     

Case–control genome-wide joint association study using semiparametric empirical model and approximate Bayes factor

We propose a semiparametric approach for the analysis of case–control genome-wide association study. Parametric components are used to model both the conditional distribution of the case status given the covariates and the distribution of genotype counts, whereas the distribution of the covariates are modelled nonparametrically. This yields a direct and joint modelling of the case status, covariates and genotype counts, and gives a better understanding of the disease mechanism and results in more reliable conclusions. Side information, such as the disease prevalence, can be conveniently incorporated into the model by an empirical likelihood approach and leads to more efficient estimates and a powerful test in the detection of disease-associated SNPs. Profiling is used to eliminate a nuisance nonparametric component, and the resulting profile empirical likelihood estimates are shown to be consistent and asymptotically normal. For the hypothesis test on disease association, we apply the approximate Bayes factor (ABF) which is computationally simple and most desirable in genome-wide association studies where hundreds of thousands to a million genetic markers are tested. We treat the approximate Bayes factor as a hybrid Bayes factor which replaces the full data by the maximum likelihood estimates of the parameters of interest in the full model and derive it under a general setting. The deviation from Hardy–Weinberg Equilibrium (HWE) is also taken into account and the ABF for HWE using cases is shown to provide evidence of association between a disease and a genetic marker. Simulation studies and an application are further provided to illustrate the utility of the proposed methodology.     

General treatment of goodness-of-fit tests based on Kullback–Leibler information

This paper introduces a general goodness-of-fit test based on the estimated Kullback–Leibler information. The test uses the Vasicek entropy estimate. Two special cases of the test for location–scale and shape families are discussed. The results are used to introduce goodness-of-fit tests for the uniform, Laplace, Weibull and beta distributions. The critical values and powers for some alternatives are obtained by simulation.