Approximating the risk score for disease diagnosis using MARS

In disease screening and diagnosis, often multiple markers are measured and combined to improve the accuracy of diagnosis. McIntosh and Pepe [Combining several screening tests: optimality of the risk score, Biometrics 58 (2002), pp. 657–664] showed that the risk score, defined as the probability of disease conditional on multiple markers, is the optimal function for classification based on the Neyman–Pearson lemma. They proposed a two-step procedure to approximate the risk score. However, the resulting receiver operating characteristic (ROC) curve is only defined in a subrange (L, h) of false-positive rates in (0,1) and the determination of the lower limit L needs extra prior information. In practice, most diagnostic tests are not perfect, and it is usually rare that a single marker is uniformly better than the other tests. Using simulation, I show that multivariate adaptive regression spline is a useful tool to approximate the risk score when combining multiple markers, especially when ROC curves from multiple tests cross. The resulting ROC is defined in the whole range of (0,1) and is easy to implement and has intuitive interpretation. The sample code of the application is shown in the appendix.     

Analysis of robust design experiments with time-dependent ordinal response characteristics: a quality improvement study from the horticulture industry

An approach to the analysis of time-dependent ordinal quality score data from robust design experiments is developed and applied to an experiment from commercial horticultural research, using concepts of product robustness and longevity that are familiar to analysts in engineering research. A two-stage analysis is used to develop models describing the effects of a number of experimental treatments on the rate of post-sales product quality decline. The first stage uses a polynomial function on a transformed scale to approximate the quality decline for an individual experimental unit using derived coefficients and the second stage uses a joint mean and dispersion model to investigate the effects of the experimental treatments on these derived coefficients. The approach, developed specifically for an application in horticulture, is exemplified with data from a trial testing ornamental plants that are subjected to a range of treatments during production and home-life. The results of the analysis show how a number of control and noise factors affect the rate of post-production quality decline. Although the model is used to analyse quality data from a trial on ornamental plants, the approach developed is expected to be more generally applicable to a wide range of other complex production systems.     

Emplaced mobilities: Lisbon as a translocality in the migration journeys of Punjabi Sikhs to Europe

The arrival in Portugal of recent migrants from the Indian subcontinent is normally a secondary movement from within Europe tied to the search for a regular pathway into legal integration in the EU. However, as favourable migration policy is not paired with easy economic integration onward migration is common. We argue that such complex migration strategies cannot be amply explored through an origin–destination model; instead we suggest that a translocal perspective provides a framework to examine connections and experiences of emplacement in places of passage/reception like Lisbon. Through a qualitative study of the migration journeys and emplaced practices of Punjabi migrants in Lisbon, our findings highlight relationality between multiple scales, elucidating how agency and structure interact at micro and macro levels in shaping migration experiences and outcomes. We show how the materiality of local community structures ensures the navigation of daily life in the city and provides pathways toward legality contributing to wider mobility regimes. Moreover, we illustrate how onward migration represents an individual strategy to realise different aspects of integration in other EU destinations challenging nation-state-bound understandings of citizenship/settlement and integration.     

Exploring types of interference between work and non-work: using a diary study approach

Studies of work and family issues have used predominately between-subject cross-sectional designs. While some researchers have called for more longitudinal studies, others have suggested that a more strategic way forward for the field is the use of daily diary studies (Frone, Russell, & Cooper, 1992). This study explores different types of interference between work and non-work domains, using a diary study methodology. This study consisted of a two-week diary study among 12 Irish employees. Analysis involved a two-step procedure involving both content analysis and interpretative phenomenological analysis (IPA). Results indicated that while individuals reported strain-based and time-based interference, evidence was also found of interference concerning persistent and intrusive thoughts. Despite some limitations to the study, this paper demonstrates that diary studies represent an opportunity for researchers to explore work and non-work experiences in a sensitive and ecologically valid way.     

A cross-cultural study on surrogate mother's empathy and maternal–foetal attachment

BackgroundTraditional and gestational surrogate mothers assist infertile couples by carrying their children. In 2005, a meta-analysis on surrogacy was conducted but no study had examined empathy and maternal–foetal attachment of surrogate mothers. Assessments of surrogate mothers show no sign of psychopathology, but one study showed differences on several MMPI-2 scales compared to a normative sample: surrogate mothers identified with stereotypically masculine traits such as assertiveness and competition. They had a higher self-esteem and lower levels of anxiety and depression.Research objectiveTo determine if there is a difference in empathy and maternal–foetal attachment of surrogate mothers compared to a comparison group of mothers.MethodsThree groups of European traditional and gestational surrogate mothers (n = 10), Anglo-Saxon traditional and gestational surrogate mothers (n = 34) and a European normative sample of mothers (n = 32) completed four published psychometric instruments: the Interpersonal Reactivity Index (empathy index), the Hospital Anxiety and Depressions Scale and the MC20, a social desirability scale. Pregnant surrogate mothers filled the Maternal Antenatal Attachment Scale (n = 11). Statistical non-parametric analyses of variance were conducted.FindingsDepending on cultural background, surrogate mothers present differences in terms of empathy, anxiety and depression, social desirability and quality of attachment to the foetus compared to a normative sample.ConclusionsEnvironment plays a role for traditional and gestational surrogacy. Surrogate mothers of both groups are less anxious and depressed than normative samples. Maternal–foetal attachment is strong with a slightly lower quality of attachment. Surrogate mother's empathy indexes are similar to normative samples, sometimes higher.     

In search of family-friendly careers? Professional strategies,work conditions and gender differences in work–family conflict

The aim of this paper is to investigate whether women in a dual-earner context acquire family-friendly jobs as a strategy to keep work–family conflict down. The analysis is based on a survey of newly graduated highly educated men and women in five occupations in Sweden (n?≈?2400). The sample was stratified by occupation and gender to minimize the influence of factors other than gender. The results show that women are more family-oriented, but also more career-oriented than men in their professional strategies. In their jobs, women have less control over work and schedules than men but a similar level of work demands. However, women face lower requirements for employer flexibility (e.g. frequent over time) and this is related to their professional strategies. Finally, women report a higher level of work–family conflict than men in the same occupation, but this gender difference becomes non-significant when accounting for women’s lower level of control. In sum, women in this sample clearly aim for both family and career and do not acquire family-friendly jobs, but aim to avoid ‘family-unfriendly’ requirements for constant availability. To some extent, this enables them to limit their work–family conflict but due to their lower control over work, women still experience more conflict than men in the same occupation.     

Stretching the borders: how international business travel affects the work–family balance

This study examined the consequences of international business travel for the balance between work–family domains by exploring how international business travellers and travellers’ partners manage the boundaries between work and family in order to maintain the balance. Interpretative phenomenological analysis was used in analysing the semi-structured interviews of 10 male travellers and 10 partners. Because of its irregular nature, international business travel affects the personal life and the family of business travellers. Work-related travel also has an impact on how travellers and their partners construct, manage and negotiate borders between work and family in order to avoid an imbalance between these domains. Integration of work and family is usually inevitable in international business traveler families. Integration may lead to role blurring and thus lead to imbalance.     

The significance of meaning. Why IPBES needs the social sciences and humanities

The term “biodiversity” is often used to describe phenomena of nature, which can be studied without a reference to the socially constructed, evaluative, or indeed normative contexts. In our paper, we challenge this conception by focusing particularly on methodological aspects of biodiversity research. We thereby engage with the idea of interdisciplinary biodiversity research as a scientific approach directed at the recognition and management of contemporary society in its ecological embedding. By doing this, we explore how research on and assessments of biodiversity can be enhanced if meaning, aspiration, desires, and related aspects of agency are methodically taken into account. In six sections, we substantiate our claim that the discourse on biodiversity (including the IPBES (Intergovernmental science-policy Platform on Biodiversity and Ecosystem Services) debate) is incomplete without contributions from the social sciences and humanities. In the introduction, a brief overview of biodiversity’s conceptual history is provided showing that “biodiversity” is a lexical invention intended to create a strong political momentum. However, that does not impede its usability as a research concept. Section 2 examines the origins of the Convention on Biological Diversity (CBD) by way of sociological discourse analysis. Subsequently, it proposes a matrix as a means to structure the ambiguities and tensions inherent in the CBD. The matrix reemphasizes our main thesis regarding the need to bring social and ethical expertise to the biodiversity discourse. In Section 3, we offer a brief sketch of the different methods of the natural and social sciences as well as ethics. This lays the groundwork for our Section 4, which explains and illustrates what social sciences and ethics can contribute to biodiversity research. Section 5 turns from research to politics and argues that biodiversity governance necessitates deliberative discourses in which participation of lay people plays an important role. Section 6 provides our conclusions.     

Armchair detectives and the social construction of falsehoods: an actor–network approach

ABSTRACT

This paper examines two large-scale cases ? the 2013 Boston bombing and the 2015 Bangkok bombing, each of which spurred an online investigation conducted by concerned citizens to find the bombers. While both bombing cases had different cultural discourses, the processes and outcomes of the online investigation were similar: there were rampant speculation and rumor-mongering, as well as false accusations and harassment of innocent suspects. The aim of the paper is to understand how such acts of mob justice happened. Using actor–network theory, a theoretical and methodological tool for mapping out the networks human and non-human interactions, I discuss two types of networks found in both investigations. The two network types demonstrate how a claim can be construed as fact or fiction through such networks of interaction. In light of debates on the proliferation of fake news and alternative facts, the findings have implications for the current and precarious state of truth in today’s society.     

Psychometric properties of the “parent-child relationship inventory” (PCRI) in a portuguese forensic sample

In Portugal, there is a gap regarding psychological tests validated for forensic contexts, particularly those related to child custody issues. The Parent–Child Relationship Inventory (PCRI) is one of the most used instruments in child custody contexts. This study aimed to analyze the psychometric properties of PCRI in a Portuguese forensic sample. PCRI factorial structure and psychometric properties were analyzed in a sample of 144 parents involved in child custody assessments. The questionnaire showed good internal consistency, except for the parental support, autonomy, and role orientation scales. It also showed good discriminant capacity. The confirmatory factor analysis did not replicate the 7-factor model proposed by Gerard. The results were discussed based on the use of PCRI in the context of child custody assessment.