Comments on the Mixture Detection Rule Used in SPC Control Charts

When calculating independently the false alarm rate of the eight usual runs rules used in SPC control chart, it appears that the proposed rule designed to detect mixture patterns corresponds to a Type-I error strongly lower than the seven other rules. This discrepancy is underlined and the mixture rule is showed to be useless both for in-control and out-of-control processes. Thus a modification of the mixture detection rule is proposed and the impact of this new mixture rule is then illustrated and discussed using Monte Carlo calculations.     

Necessary and Sufficient Condition for Nonsingular Fisher Information Matrix in ARMA and Fractional ARIMA Models

It is demonstrated that a necessary and sufficient condition for the Fisher information matrix of a causal and invertible ARMA to be nonsingular is that the model not be redundant; that is, the autoregressive and moving-average polynomials have no roots in common. This result is also extended to fractional ARIMA models.     

ON ENTROPY BASED TESTS FOR EXPONENTIALITY

ABSTRACT

Recent literature has proposed a test for exponentiality based on sample entropy. We consider transformations of the observations which turn the test of exponentiality into one of uniformity and use a corresponding test based on entropy. The test based on the transformed variables performs better in many cases of interest.     

Approximations of the Distributions of Test Statistics for Homogeneity of a Product Multinomial Model

Statistics R ^a based on power divergence can be used for testing the homogeneity of a product multinomial model. All R ^a have the same chi-square limiting distribution under the null hypothesis of homogeneity. R ⁰ is the log likelihood ratio statistic and R ¹ is Pearson's X ² statistic. In this article, we consider improvement of approximation of the distribution of R ^a under the homogeneity hypothesis. The expression of the asymptotic expansion of distribution of R ^a under the homogeneity hypothesis is investigated. The expression consists of continuous and discontinuous terms. Using the continuous term of the expression, a new approximation of the distribution of R ^a is proposed. A moment-corrected type of chi-square approximation is also derived. By numerical comparison, we show that both of the approximations perform much better than that of usual chi-square approximation for the statistics R ^a when a ≤ 0, which include the log likelihood ratio statistic.     

Constructions of Residual Treatment Effects Designs for Comparing Test Treatments with a Control

This article deals with residual treatment effects designs for the purpose of comparing v test treatments with a control treatment when the number of periods is no larger than v + 1. Control balanced residual treatment effects designs, which are Schur-optimal, are considered. Some methods of their construction are given.     

An Approximation for the Test of the Equality of the Smallest Eigenvalues of a Covariance Matrix

A limiting distribution of the likelihood ratio statistic for the test of the equality of the q smallest eigenvalues of a covariance matrix is obtained. This distribution can be used as an alternative to the chi-squared distribution which is usually used with this test. It is shown that this new method yields reasonable significance levels for those situations in which the chi-squared approximation is inadequate.     

A Design For Survival Studies: A Multi-regional Trial With Unrecognized Heterogeneity

A bridging study defined by ICH E5 is usually conducted in the new region after the test product has been approved for commercial marketing in the original region due to its proven efficacy and safety. However, extensive duplication of clinical evaluation in the new region not only requires valuable development resources but also delay availability of the test product to the needed patients in the new regions. To shorten the drug lag or the time lag for approval, simultaneous drug development, submission, and approval in the world may be desirable. Recently, multi-regional trials have attracted much attention from sponsors as well as regulatory authorities. Current methods for sample determination are based on the assumption that true treatment effect is uniform across regions. However, unrecognized heterogeneity among patients as ethnic or genetic factor will effect patients’ survival. Using the simple log-rank test for analysis of treatment effect on survival in studies under heterogeneity may be severely underpowered. In this article, we address the issue that the treatment effects are different among regions to design a multi-regional trial. The optimal log-rank test is employed to deal with the heterogeneous effect size among regions. The test statistic for the overall treatment effect is used to determine the total sample size for a multi-regional trial and the consistent trend and the proposed criteria are used to rationalize partition sample size to each region.     

A Multivariate Generalized Poisson Regression Model

A multivariate generalized Poisson regression model based on the multivariate generalized Poisson distribution is defined and studied. The regression model can be used to describe a count data with any type of dispersion. The model allows for both positive and negative correlation between any pair of the response variables. The parameters of the regression model are estimated by using the maximum likelihood method. Some test statistics are discussed, and two numerical data sets are used to illustrate the applications of the multivariate count data regression model.     

The Estimation and Testing of the Cointegration Order Based on the Frequency Domain

ABSTRACT

This article proposes a method to estimate the degree of cointegration in bivariate series and suggests a test statistic for testing noncointegration based on the determinant of the spectral density matrix for the frequencies close to zero. In the study, series are assumed to be I(d), 0 < d ? 1, with parameter d supposed to be known. In this context, the order of integration of the error series is I(d ? b), b ∈ [0, d]. Besides, the determinant of the spectral density matrix for the dth difference series is a power function of b. The proposed estimator for b is obtained here performing a regression of logged determinant on a set of logged Fourier frequencies. Under the null hypothesis of noncointegration, the expressions for the bias and variance of the estimator were derived and its consistency property was also obtained. The asymptotic normality of the estimator, under Gaussian and non-Gaussian innovations, was also established. A Monte Carlo study was performed and showed that the suggested test possesses correct size and good power for moderate sample sizes, when compared with other proposals in the literature. An advantage of the method proposed here, over the standard methods, is that it allows to know the order of integration of the error series without estimating a regression equation. An application was conducted to exemplify the method in a real context.