A simulation study on power comparisons for group sequential tests of non-parametric statistics

In this article, a group sequential test (GST) of non-parametric statistics for survival data is briefly reviewed. An asymptotic joint distribution of the test statistics, obtained after each interim analysis, is given to illustrate the applicability of the critical values of the GST procedures. It should be noted that censored observations are generally seen in survival data. Therefore, if one makes power calculations irrespective of censoring, reliable results may not be achieved, due to the lack of information about the censoring structure. A wide simulation study, covering different censoring rates and tied observations, is conducted to make the power comparisons under various scenarios. The simulation results are interpreted and compared with the results obtained by using power analysis and sample size (PASS) software.     

Order statistics from non-identical right-truncated Lomax random variables with applications

In this paper, we derive some recurrence relations for the single and the product moments of order statistics from n independent and non-identically distributed Lomax and right-truncated Lomax random variables. These recurrence relations are simple in nature and could be used systematically in order to compute all the single and product moments of all order statistics in a simple recursive manner. The results for order statistics from the multiple-outlier model (with a slippage of p observations) are deduced as special cases. We then apply these results by examining the robustness of censored BLUE's to the presence of multiple outliers. Received: November 30, 1998; revised version: March 8, 2000     

On designing an acceptance sampling plan for the Pareto lifetime model

In this paper, the design of reliability sampling plans for the Pareto lifetime model under progressive Type-II right censoring is considered. Sampling plans are derived using the decision theoretic approach with a suitable loss or cost function that consists of sampling cost, rejection cost, and acceptance cost. The decision rule is based on the estimated reliability function. Plans are constructed within the Bayesian context using the natural conjugate prior. Simulations for evaluating the Bayes risk are carried out and the optimal sampling plans are reported for various sample sizes, observed number of failures and removal probabilities.     

On Non-parametric Estimation of the Survival Function with Competing Risks

The non-parametric maximum likelihood estimators (MLEs) are derived for survival functions associated with individual risks or system components in a reliability framework. Lifetimes are observed for systems that contain one or more of those components. Analogous to a competing risks model, the system is assumed to fail upon the first instance of any component failure; i.e. the system is configured in series. For any given risk or component type, the asymptotic distribution is shown to depend explicitly on the unknown survival function of the other risks, as well as the censoring distribution. Survival functions with increasing failure rate are investigated as a special case. The order restricted MLE is shown to be consistent under mild assumptions of the underlying component lifetime distributions.     

Urn Sampling and the Proportional Hazard Model

This paper investigates the urn sampling analogue for the score statistic relating survival to covariates assuming a proportional hazard model. The exact permutation distribution can be calculated as well as the exact low order moments for arbitrary censoring patterns. The asymptotic distribution of the score statistic is an easy consequence. The method is naturally extended to deal with the multivariate case, time varying covariates and interval censoring. Finally the relationship between the censoring process, the survival times and covariates are studied considering different reference sets for the distribution of the score statistic. Some assumptions about the censoring process are investigated and as a consequence the effect of censoring is clarified.     

Exact confidence bounds for an exponential parameter under hybrid censoring

Consider a life testing experiment in which n units are put on test, successive failure times are recorded, and the observation is terminated either at a specified number r of failures or a specified time T whichever is reached first. This mixture of type I and type II censoring schemes, called hybrid censoring, is of wide use. Under this censoring scheme and the assumption of an exponential life distribution, the distribution of the maximum likelihood estimator of the mean life θ is derived. It is then used to construct an exact lower confidence bound for θ.     

On the incidence–prevalence relation and length‐biased sampling

For many diseases, logistic constraints render large incidence studies difficult to carry out. This becomes a drawback, particularly when a new study is needed each time the incidence rate is investigated in a new population. By carrying out a prevalent cohort study with follow‐up it is possible to estimate the incidence rate if it is constant. The authors derive the maximum likelihood estimator (MLE) of the overall incidence rate, λ, as well as age‐specific incidence rates, by exploiting the epidemiologic relationship, (prevalence odds) = (incidence rate) × (mean duration) (P/[1 ? P] = λ × µ). The authors establish the asymptotic distributions of the MLEs and provide approximate confidence intervals for the parameters. Moreover, the MLE of λ is asymptotically most efficient and is the natural estimator obtained by substituting the marginal maximum likelihood estimators for P and µ into P/[1 ? P] = λ × µ. Following‐up the subjects allows the authors to develop these widely applicable procedures. The authors apply their methods to data collected as part of the Canadian Study of Health and Ageing to estimate the incidence rate of dementia amongst elderly Canadians. The Canadian Journal of Statistics © 2009 Statistical Society of Canada     

Simultaneous Confidence Intervals for the Difference of Two Survival Functions

In comparing two treatments with failure time observations, confidence bands for the "difference" of two survival curves provide useful information about a global picture of the treatment difference over time. In this note, we propose a rather simple procedure for constructing such simultaneous confidence intervals. Our technique can also be used in the one-sample case, which has been extensively studied in the literature.     

Biased sampling with right censoring: A note on sun,Cui & Tiwari (2002)

Sun, Cui & Tiwari (2002) studied the asymptotic behaviour of certain goodness‐of‐fit tests in the presence of biased sampling and right censoring. The author illustrates that unfortunately, an assumption made by Sun, Cui and Tiwari on the independence between failure and censoring time fails to hold in many important applications, which limits the applicability of their results.