On Non-parametric Estimation of the Survival Function with Competing Risks

The non-parametric maximum likelihood estimators (MLEs) are derived for survival functions associated with individual risks or system components in a reliability framework. Lifetimes are observed for systems that contain one or more of those components. Analogous to a competing risks model, the system is assumed to fail upon the first instance of any component failure; i.e. the system is configured in series. For any given risk or component type, the asymptotic distribution is shown to depend explicitly on the unknown survival function of the other risks, as well as the censoring distribution. Survival functions with increasing failure rate are investigated as a special case. The order restricted MLE is shown to be consistent under mild assumptions of the underlying component lifetime distributions.     

Urn Sampling and the Proportional Hazard Model

This paper investigates the urn sampling analogue for the score statistic relating survival to covariates assuming a proportional hazard model. The exact permutation distribution can be calculated as well as the exact low order moments for arbitrary censoring patterns. The asymptotic distribution of the score statistic is an easy consequence. The method is naturally extended to deal with the multivariate case, time varying covariates and interval censoring. Finally the relationship between the censoring process, the survival times and covariates are studied considering different reference sets for the distribution of the score statistic. Some assumptions about the censoring process are investigated and as a consequence the effect of censoring is clarified.     

An EOQ inventory model for items with Weibull distribution deterioration,ramp type demand rate and partial backlogging

In this paper, an EOQ inventory model is presented depleted not only by demand but also by Weibull distribution deterioration, in which the demand rate is assumed that with a ramp type function of time. In the model, shortages are allowed partial backlogging and the backlogging rate is variable and is dependent on waiting time for the next replenishment. The method is illustrated by three numerical examples, and sensitivity analysis of the optimal solution with respect to parameters of the system is carried out.     

Estimating the exponential reliability function for a system in series with type II censored data

The problem of estimating the one parameter exponential reliability function for a system composed of l componentes in series is considered. Under the type II censoring scheme, the Bayes nature of the minimum variance unbiased estimator is demonstrated and the admissibility of related generalized Bayes estimators is established. For the one component case, the best unbiased estimator is admissible.     

Exact confidence bounds for an exponential parameter under hybrid censoring

Consider a life testing experiment in which n units are put on test, successive failure times are recorded, and the observation is terminated either at a specified number r of failures or a specified time T whichever is reached first. This mixture of type I and type II censoring schemes, called hybrid censoring, is of wide use. Under this censoring scheme and the assumption of an exponential life distribution, the distribution of the maximum likelihood estimator of the mean life θ is derived. It is then used to construct an exact lower confidence bound for θ.     

On the incidence–prevalence relation and length‐biased sampling

For many diseases, logistic constraints render large incidence studies difficult to carry out. This becomes a drawback, particularly when a new study is needed each time the incidence rate is investigated in a new population. By carrying out a prevalent cohort study with follow‐up it is possible to estimate the incidence rate if it is constant. The authors derive the maximum likelihood estimator (MLE) of the overall incidence rate, λ, as well as age‐specific incidence rates, by exploiting the epidemiologic relationship, (prevalence odds) = (incidence rate) × (mean duration) (P/[1 ? P] = λ × µ). The authors establish the asymptotic distributions of the MLEs and provide approximate confidence intervals for the parameters. Moreover, the MLE of λ is asymptotically most efficient and is the natural estimator obtained by substituting the marginal maximum likelihood estimators for P and µ into P/[1 ? P] = λ × µ. Following‐up the subjects allows the authors to develop these widely applicable procedures. The authors apply their methods to data collected as part of the Canadian Study of Health and Ageing to estimate the incidence rate of dementia amongst elderly Canadians. The Canadian Journal of Statistics © 2009 Statistical Society of Canada     

Multi-step variance minimization in sequential tests

We introduce a multi-step variance minimization algorithm for numerical estimation of Type I and Type II error probabilities in sequential tests. The algorithm can be applied to general test statistics and easily built into general design algorithms for sequential tests. Our simulation results indicate that the proposed algorithm is particularly useful for estimating tail probabilities, and may lead to significant computational efficiency gains over the crude Monte Carlo method.     

Simultaneous Confidence Intervals for the Difference of Two Survival Functions

In comparing two treatments with failure time observations, confidence bands for the "difference" of two survival curves provide useful information about a global picture of the treatment difference over time. In this note, we propose a rather simple procedure for constructing such simultaneous confidence intervals. Our technique can also be used in the one-sample case, which has been extensively studied in the literature.     

二战时期的中美友谊

二战时期反对共同的敌人,是中美友谊关系的基础。太平洋战争爆发后,中美两国共同抗击法西斯势力,成了一条战壕的战友,以血肉凝成的中美两国人民的友谊迅速升华。对于美国支持的中国抗战,中共也曾表示感谢。史迪威、陈纳德是二战时期中美友谊的体现者和历史见证人。     

ON A MULTIPLE THREE-DECISION PROCEDURE FOR COMPARING SEVERAL TREATMENTS WITH A CONTROL

For the two-sided comparisons of several treatments with a control, a common statistical problem is to decide which treatments are better than the control and which are worse than the control. This paper studies a multiple three-decision procedure for this purpose, proposed by Bohrer (1979) and Bohrer et al. (1981), and provides tables of critical points to facilitate the application of the procedure. The paper defines a power function of the procedure, and tabulates sample sizes necessary to guarantee a given power level. It addresses the problem of optimal sampling allocation in order to maximize the power for a given total sample size, and considers generalization to the situation where the treatments might have unequal numbers of observations.