Optimal designs for multivariate logistic mixed models with longitudinal data

This paper considers the optimal design problem for multivariate mixed-effects logistic models with longitudinal data. A decomposition method of the binary outcome and the penalized quasi-likelihood are used to obtain the information matrix. The D-optimality criterion based on the approximate information matrix is minimized under different cost constraints. The results show that the autocorrelation coefficient plays a significant role in the design. To overcome the dependence of the D-optimal designs on the unknown fixed-effects parameters, the Bayesian D-optimality criterion is proposed. The relative efficiencies of designs reveal that both the cost ratio and autocorrelation coefficient play an important role in the optimal designs.     

A Comparative Study of Model-based Tests of Independence for Ordinal Data Using the Bootstrap

When analyzing categorical data using loglinear models in sparse contingency tables, asymptotic results may fail. In this paper the empirical properties of three commonly used asymptotic tests of independence, based on the uniform association model for ordinal data, are investigated by means of Monte Carlo simulation. Five different bootstrapped tests of independence are presented and compared to the asymptotic tests. The comparisons are made with respect to both size and power properties of the tests. Results indicate that the asymptotic tests have poor size control. The test based on the estimated association parameter is severely conservative and the two chi-squared tests (Pearson, likelihood-ratio) are both liberal. The bootstrap tests that either use a parametric assumption or are based on non-pivotal test statistics do not perform better than the asymptotic tests in all situations. The bootstrap tests that are based on approximately pivotal statistics provide both adjustment of size and enhancement of power. These tests are therefore recommended for use in situations similar to those included in the simulation study.     

On An Intriguing Distributional Identity

For a continuous random variable X with support equal to (a, b), with c.d.f. F, and g: Ω₁ → Ω₂ a continuous, strictly increasing function, such that Ω₁∩Ω₂?(a, b), but otherwise arbitrary, we establish that the random variables F(X) ? F(g(X)) and F(g^{? 1}(X)) ? F(X) have the same distribution. Further developments, accompanied by illustrations and observations, address as well the equidistribution identity U ? ψ(U) = ^dψ^{? 1}(U) ? U for U ～ U(0, 1), where ψ is a continuous, strictly increasing and onto function, but otherwise arbitrary. Finally, we expand on applications with connections to variance reduction techniques, the discrepancy between distributions, and a risk identity in predictive density estimation.     

Some new constructions of circular balanced repeated measurements designs

Repeated measurements designs are widely used in medicine, pharmacology, animal sciences, and psychology. In this article, some infinite series are developed to generate the balanced repeated measurements designs for p (periods) even. For p odd, construction procedures are also described. Catalogues of the proposed designs are also presented for p = 5, 7, 9, when v ≤ 100.     

Characterization of singular balanced fractional sm factorial designs derivable from balanced arrays with maximum number of constraints

An upper bound on the maximum number of constraints for s-symbol balanced arrays is derived. It is shown that balanced fractional s^m factorial designs derived from some balanced arrays with the maximum possible number of constraints become singular.     

On the existence of linear trend free block designs

We present a class of counerexamples for a conjecture on the existence or linear trend free block designs we will also prove a considerably weakened version of this conjecture which will determine all combinations of designs parmetres for which the class of linear trend free block designs is non empty.     

Construction of incomplete Sudoku square and partially balanced incomplete block designs

Abstract

The present article deals with the study of association among the elements of a Sudoku square. In this direction, we have defined an association scheme and constructed incomplete Sudoku square designs which are capable of studying four explanatory variables and also happen to be the designs for two-way elimination of heterogeneity. Some series of Partially Balanced Incomplete Block (PBIB) designs have also been obtained.     

Randomization tests in recursive response-adaptive randomization procedures

In a randomized clinical trial, response-adaptive randomization procedures use the information gathered, including the previous patients' responses, to allocate the next patient. In this setting, we consider randomization-based inference. We provide an algorithm to obtain exact p-values for statistical tests that compare two treatments with dichotomous responses. This algorithm can be applied to a family of response adaptive randomization procedures which share the following property: the distribution of the allocation rule depends only on the imbalance between treatments and on the imbalance between successes for treatments 1 and 2 in the previous step. This family includes some outstanding response adaptive randomization procedures. We study a randomization test to contrast the null hypothesis of equivalence of treatments and we show that this test has a similar performance to that of its parametric counterpart. Besides, we study the effect of a covariate in the inferential process. First, we obtain a parametric test, constructed assuming a logit model which relates responses to treatments and covariate levels, and we give conditions that guarantee its asymptotic normality. Finally, we show that the randomization test, which is free of model specification, performs as well as the parametric test that takes the covariate into account.     

Factor screening in nonregular two-level designs based on projection-based variable selection

In this paper, we focus on the problem of factor screening in nonregular two-level designs through gradually reducing the number of possible sets of active factors. We are particularly concerned with situations when three or four factors are active. Our proposed method works through examining fits of projection models, where variable selection techniques are used to reduce the number of terms. To examine the reliability of the methods in combination with such techniques, a panel of models consisting of three or four active factors with data generated from the 12-run and the 20-run Plackett–Burman (PB) design is used. The dependence of the procedure on the amount of noise, the number of active factors and the number of experimental factors is also investigated. For designs with few runs such as the 12-run PB design, variable selection should be done with care and default procedures in computer software may not be reliable to which we suggest improvements. A real example is included to show how we propose factor screening can be done in practice.     

关于含参变量无穷积分的绝对一致收敛的注记

本文从一个反例 ,证明了即使∫∞af(x ,t)dt绝对收敛且一致收敛 ,但不能推出∫∞a |f(x ,t) |dt一致收敛。