图像时代包装设计之美学解析

图像时代的包装设计与以往时代有着显著的差异,商品对象的使用价值被边缘化,功能性要素隐退至二线,视觉性的图像符号成为设计关注的焦点.整个设计呈现出区别于以往时代的美学新质:强调图像的观赏性,图像能指的虚拟性,图像审美的随意性和前快乐性,图像生产的间接性.这种新质重构了审美主体的心理,生成了一种新感性,并以一种无意识的方式将人们的消费欲望内化为一种时尚信仰与自觉的情感选择,从而建构了一种关于消费主义的价值神话与话语霸权,完成了物(商品)对人(主体)的控制,深刻地表征了人的复杂的社会关系与权力形式.     

浅析城市色彩设计对于城市规划的意义

城市色彩规划设计在现代城市建设中的具有重大的现实意义,主要体现在以下几个方面：城市色彩是城市人居环境质量的重要组成部分,是城市历史文化的重要载体,是城市现代文明的体现,同时也是矫正城市建筑无序状态的重要手段。     

Logistic模型配合家禽生长资料参数估计方法比较的Monte Carlo研究

本文用Logistic模型配合Monte Cario方法模拟的30个家禽生长资料,以比较Logis-tic模型参数估计的最小一乘法、最小二乘法和minx~2法,以及线性化方法。结果表明:最小二乘法(LS)和最小一乘法结果相当,均优于ininx~2方法;参数估计的线性化方法结果较差,以改良三点法效果较好。     

Determining the minimum duration of treatment in tuberculosis: An order restricted non-inferiority trial design

Tuberculosis (TB) is one of the biggest killers among infectious diseases worldwide. Together with the identification of drugs that can provide benefits to patients, the challenge in TB is also the optimisation of the duration of these treatments. While conventional duration of treatment in TB is 6 months, there is evidence that shorter durations might be as effective but could be associated with fewer side effects and may be associated with better adherence. Based on a recent proposal of an adaptive order-restricted superiority design that employs the ordering assumptions within various duration of the same drug, we propose a non-inferiority (typically used in TB trials) adaptive design that effectively uses the order assumption. Together with the general construction of the hypothesis testing and expression for type I and type II errors, we focus on how the novel design was proposed for a TB trial concept. We consider a number of practical aspects such as choice of the design parameters, randomisation ratios, and timings of the interim analyses, and how these were discussed with the clinical team.     

A comparative study of adaptive trial designs for dose optimization

Recently, the US Food and Drug Administration Oncology Center of Excellence initiated Project Optimus to reform the dose optimization and dose selection paradigm in oncology drug development. The agency pointed out that the current paradigm for dose selection—based on the maximum tolerated dose (MTD)—is not sufficient for molecularly targeted therapies and immunotherapies, for which efficacy may not increase after the dose reaches a certain level. In these cases, it is more appropriate to identify the optimal biological dose (OBD) that optimizes the risk–benefit tradeoff of the drug. Project Optimus has spurred tremendous interest and urgent need for guidance on designing dose optimization trials. In this article, we review several representative dose optimization designs, including model-based and model-assisted designs, and compare their operating characteristics based on 10,000 randomly generated scenarios with various dose-toxicity and dose-efficacy curves and some fixed representative scenarios. The results show that, compared with model-based designs, model-assisted methods have advantages of easy-to-implement, robustness, and high accuracy to identify OBD. Some guidance is provided to help biostatisticians and clinicians to choose appropriate dose optimization methods in practice.