Comparison of causal effect estimators under exposure misclassification

Over the past decades, various principles for causal effect estimation have been proposed, all differing in terms of how they adjust for measured confounders: either via traditional regression adjustment, by adjusting for the expected exposure given those confounders (e.g., the propensity score), or by inversely weighting each subject's data by the likelihood of the observed exposure, given those confounders. When the exposure is measured with error, this raises the question whether these different estimation strategies might be differently affected and whether one of them is to be preferred for that reason. In this article, we investigate this by comparing inverse probability of treatment weighted (IPTW) estimators and doubly robust estimators for the exposure effect in linear marginal structural mean models (MSM) with G-estimators, propensity score (PS) adjusted estimators and ordinary least squares (OLS) estimators for the exposure effect in linear regression models. We find analytically that these estimators are equally affected when exposure misclassification is independent of the confounders, but not otherwise. Simulation studies reveal similar results for time-varying exposures and when the model of interest includes a logistic link.     

Applications and asymptotic power of marginal-free tests of stochastic vectorial independence

Fully nonparametric tests for the independence between random vectors are studied in this paper. The test statistics are functionals of an empirical process defined as the difference between the joint empirical copula and the product of the empirical copulas associated to the vectors that are suspected to be independent. The validity of a weighted bootstrap procedure is established, which allows for a quick computation of p-values. A special attention is given to the asymptotic behavior of the tests under contiguous sequences of distributions. Finally, a characteristic of the copulas in the Archimedean class in terms of independence of vectors is exploited in order to propose a new goodness-of-fit procedure.     

Exact likelihood inference for Laplace distribution based on Type-II censored samples

We develop exact inference for the location and scale parameters of the Laplace (double exponential) distribution based on their maximum likelihood estimators from a Type-II censored sample. Based on some pivotal quantities, exact confidence intervals and tests of hypotheses are constructed. Upon conditioning first on the number of observations that are below the population median, exact distributions of the pivotal quantities are expressed as mixtures of linear combinations and of ratios of linear combinations of standard exponential random variables, which facilitates the computation of quantiles of these pivotal quantities. Tables of quantiles are presented for the complete sample case.     

The Gamma-count distribution in the analysis of experimental underdispersed data

Event counts are response variables with non-negative integer values representing the number of times that an event occurs within a fixed domain such as a time interval, a geographical area or a cell of a contingency table. Analysis of counts by Gaussian regression models ignores the discreteness, asymmetry and heteroscedasticity and is inefficient, providing unrealistic standard errors or possibly negative predictions of the expected number of events. The Poisson regression is the standard model for count data with underlying assumptions on the generating process which may be implausible in many applications. Statisticians have long recognized the limitation of imposing equidispersion under the Poisson regression model. A typical situation is when the conditional variance exceeds the conditional mean, in which case models allowing for overdispersion are routinely used. Less reported is the case of underdispersion with fewer modeling alternatives and assessments available in the literature. One of such alternatives, the Gamma-count model, is adopted here in the analysis of an agronomic experiment designed to investigate the effect of levels of defoliation on different phenological states upon the number of cotton bolls. Data set and code for analysis are available as online supplements. Results show improvements over the Poisson model and the semi-parametric quasi-Poisson model in capturing the observed variability in the data. Estimating rather than assuming the underlying variance process leads to important insights into the process.     

Semiparametric Analysis of Network Formation

ABSTRACT

We consider a statistical model for directed network formation that features both node-specific parameters that capture degree heterogeneity and common parameters that reflect homophily among nodes. The goal is to perform statistical inference on the homophily parameters while treating the node-specific parameters as fixed effects. Jointly estimating all parameters leads to incidental-parameter bias and incorrect inference. As an alternative, we develop an approach based on a sufficient statistic that separates inference on the homophily parameters from estimation of the fixed effects. The estimator is easy to compute and can be applied to both dense and sparse networks, and is shown to have desirable asymptotic properties under sequences of growing networks. We illustrate the improvements of this estimator over maximum likelihood and bias-corrected estimation in a series of numerical experiments. The technique is applied to explain the import and export patterns in a dense network of countries and to estimate a more sparse advice network among attorneys in a corporate law firm.     

Optimal Information Processing and Bayes's Theorem

In this article statistical inference is viewed as information processing involving input information and output information. After introducing information measures for the input and output information, an information criterion functional is formulated and optimized to obtain an optimal information processing rule (IPR). For the particular information measures and criterion functional adopted, it is shown that Bayes's theorem is the optimal IPR. This optimal IPR is shown to be 100% efficient in the sense that its use leads to the output information being exactly equal to the given input information. Also, the analysis links Bayes's theorem to maximum-entropy considerations.     

A class of weighted normal distributions and its variants useful for inequality constrained analysis

This article develops a class of the weighted normal distributions for which the probability density function has the form of a product of a normal density and a weight function. The class constitutes marginal distributions obtained from various kinds of doubly truncated bivariate normal distributions. This class of distributions strictly includes the normal, skew–normal and two-piece skew–normal and is useful for selection modelling and inequality constrained normal mean analysis. Some distributional properties and Bayesian perspectives of the class are given. Probabilistic representation of the distributions is also given. The representation is shown to be straightforward to specify distribution and to implement computation, with output readily adapted for required analysis. Necessary theories and illustrative examples are provided.     

Controlled Direct and Mediated Effects: Definition,Identification and Bounds

Abstract. Results are given which provide bounds for controlled direct effects when nounmeasured confounding assumptions required for the identification of these effects do not hold. Previous results concerning bounds for controlled direct effects rely on monotonicity relationships between the treatment, mediator and the outcome themselves; the results presented in this article instead assume that monotonicity relationships hold between the unmeasured confounding variable or variables and the treatment, mediator and outcome. Whereas prior results give bounds that contain the null hypothesis of no direct effect, the results presented here will in many instances yield bounds that do not contain the null hypothesis of no direct effect. For contexts in which a set of variables intercepts all paths between a treatment and an outcome, it is possible to provide a definition for a controlled mediated effect. We discuss the identification of these controlled mediated effects; the bounds for controlled direct effects are applicable also to controlled mediated effects. An example is given to illustrate how the results in the article can be used to draw inferences about direct and mediated effects in the presence of unmeasured confounding variables.     

认知语境的构建

本文在关联理论的框架下讨论发话人怎袢通过语言和非语言手段制约受话人的认知语境以及受话人如何在认知环境中选择并延伸认知语境.     

浅谈语境与交际

本文从语用学角度出发探讨了语境与交际的关系.重点论述了人们在交际过程中,在交际模式的指导下如何利用语境,寻找到最佳的关联,推理出说话者的真正意图,具体分析了语境在交际中所起的重大作用.