Bayesian Treatment of Model Uncertainty for Partially Applicable Models

This article discusses how analyst's or expert's beliefs on the credibility and quality of models can be assessed and incorporated into the uncertainty assessment of an unknown of interest. The proposed methodology is a specialization of the Bayesian framework for the assessment of model uncertainty presented in an earlier paper. This formalism treats models as sources of information in assessing the uncertainty of an unknown, and it allows the use of predictions from multiple models as well as experimental validation data about the models’ performances. In this article, the methodology is extended to incorporate additional types of information about the model, namely, subjective information in terms of credibility of the model and its applicability when it is used outside its intended domain of application. An example in the context of fire risk modeling is also provided.     

On the construction of optimal experimental designs: a penalty approach

Tn optimal experimental design theory there are well-known situations, in which additional constraints are implied to the design set. These constraints destroy in general the simplex structure of the set of feasible points of the design set. Thus the available iteration procedures for the unrestricted case are no longer applicable.

In this paper a penalty approach is suggested which transforms the restricted problem to the unrestricted case and allows the application of well-known algorithms such as the Fedorov-Wynn-type or the projected gradient procedure.     

关于留数定理的一个推广

研究了留数定理的有关问题,通过举例论证和归纳推理等证明方法,得到了单个留数定理的一个推广结论,最后将此结论应用于一些积分问题中.     

On asymptotic distribution of prediction in functional linear regression

There has been substantial recent attention on problems involving a functional linear regression model with scalar response. Among them, there have been few works dealing with asymptotic distribution of prediction in functional linear regression models. In recent literature, the centeral limit theorem for prediction has been discussed, but the proof and conditions under which the random bias terms for a fixed predictor converge to zero have been ignored so that the impact of these terms on the convergence of the prediction has not been well understood. Clarifying the proof and conditions under which the bias terms converge to zero, we show that the asymptotic distribution of the prediction is normal. Furthermore, we have derived those results related to other terms that already obtained by others, under milder conditions. Finally, we conduct a simulation study to investigate performance of the asymptotic distribution under various parameter settings.     

Reconciliation with the Utility of Chance by Elaborated Outcomes Destroys the Axiomatic Basis of Expected Utility Theory

Expected utility theory does not directly deal with the utility of chance. It has been suggested in the literature (Samuelson, 1952, Markowitz, 1959) that this can be remedied by an approach which explicitly models the emotional consequences which give rise to the utility of chance. We refer to this as the elaborated outcomes approach. It is argued that the elaborated outcomes approach destroys the possibility of deriving a representation theorem based on the usual axioms of expected utility theory. This is shown with the help of an example due to Markowitz. It turns out that the space of conceivable lotteries over elaborated outcomes is too narrow to permit the application of the axioms. Moreover it is shown that a representation theorem does not hold for the example.     

On the coase theorem and coalitional stability: the principle of equal relative concession

The Coase theorem is argued to be incompatible with bargaining set stability due to a tension between the grand coalition and sub-coalitions. We provide a counter-intuitive argument to demonstrate that the Coase theorem may be in complete consonance with bargaining set stability. We establish that an uncertainty concerning the formation of sub-coalitions will explain such compatibility: each agent fears that others may `gang up' against him and this fear forces the agents to negotiate. The grand coalition emerges from the negotiations if each agent uses the principle of equal relative sacrifice to determine the actual allocation. We also establish the rational basis for the choice of the principle of equal relative concession by the negotiating agents. Hence we argue that the Coase theorem will be valid even if there are stable sub-coalitions.     

A general central limit theorem and a subsampling variance estimator for α‐mixing point processes

We establish a central limit theorem for multivariate summary statistics of nonstationary α‐mixing spatial point processes and a subsampling estimator of the covariance matrix of such statistics. The central limit theorem is crucial for establishing asymptotic properties of estimators in statistics for spatial point processes. The covariance matrix subsampling estimator is flexible and model free. It is needed, for example, to construct confidence intervals and ellipsoids based on asymptotic normality of estimators. We also provide a simulation study investigating an application of our results to estimating functions.     

When is n large enough? Looking for the right sample size to estimate proportions

The central limit theorem indicates that when the sample size goes to infinite, the sampling distribution of means tends to follow a normal distribution; it is the basis for the most usual confidence interval and sample size formulas. This study analyzes what sample size is large enough to assume that the distribution of the estimator of a proportion follows a Normal distribution. Also, we propose the use of a correction factor in sample size formulas to ensure a confidence level even when the central limit theorem does not apply for these distributions.     

Analysis of microtubule dynamics using growth curve models

Microtubules are part of the structural network within a cell's cytoplasm, providing structural support as well as taking part in many of the cellular processes. A large body of data provide evidence that dynamics of microtubules in a cell is reponsible for the performance of many critical cellular functions such as cell division. In this article, we study the effect of four different isoforms of a protein tau on microtubule dynamics using growth curve models. The results show that a linear growth curve model is sufficient to explain the data. Moreover, we find that a mutated version of a 3-repeat tau protein has a similar effect as a 4-repeat tau protein on microtubule dynamics. The latter findings conform with the biological understanding of the effect of the protein tau on microtubule dynamics.