Comparing mean ranks for repeated measures data

Rank tests are considered that compare t treatments in repeated measures designs. A statistic is given that contains as special cases several that have been proposed for this problem, including one that corresponds to the randomized block ANOVA statistic applied to the rank transformed data. Another statistic is proposed, having a null distribution holding under more general conditions, that is the rank transform of the Hotelling statistic for repeated measures. A statistic of this type is also given for data that are ordered categorical rather than fully rankedo Unlike the Friedman statistic, the statistics discussed in this article utilize a single ranking of the entire sample. Power calculations for an underlying normal distribution indicate that the rank transformed ANOVA test can be substantially more powerful than the Friedman test.     

An approximation for analyzing a broad class of implicitly and explicitly defined estimators

An approximation is presented that can be used to gain insight into the characteristics – such as outlier sensitivity, bias, and variability – of a wide class of estimators, including maximum likelihood and least squares. The approximation relies on a convenient form for an arbitrary order Taylor expansion in a multivariate setting. The implicit function theorem can be used to construct the expansion when the estimator is not defined in closed form. We present several finite-sample and asymptotic properties of such Taylor expansions, which are useful in characterizing the difference between the estimator and the expansion.     

Estimation of gene/haplotype frequencies in genetic marker systems based on phenotype data

Two equivalent methods (gene counting and maximum likelihood) for estimating gene frequencies in a general genetic marker system based on observed phenotype data are derived. Under the maximum likelihood approach, an expression is given for the estimated covariance matrix from which estimated standard errors of the estimators can be found. In addition, consideration is given to the problem of estimating gene frequencies when there are available several independent population data sets.     

Smoothed estimates for nonlinear time series models with irregular data

Time series data observed at unequal time intervals (irregular data) occur quite often and this usually poses problems in its analysis. A recursive form of the exponentially smoothed estimated is here proposed for a nonlinear model with irregularly observed data and its asymptotic properties are discussed An alternative smoother to that of Wright (1985) is also derived. Numerical comparison is made between the resulting estimates and other smoothed estimates.     

Estimation of the location and scale parameters of the extreme value distmbution based on multiply type-II censored samples

In this paper, we consider the problem of estimating the location and scale parameters of an extreme value distribution based on multiply Type-II censored samples. We first describe the best linear unbiased estimators and the maximum likelihood estimators of these parameters. After observing that the best linear unbiased estimators need the construction of some tables for its coefficients and that the maximum likelihood estimators do not exist in an explicit algebraic form and hence need to be found by numerical methods, we develop approximate maximum likelihood estimators by appropriately approximating the likelihood equations. In addition to being simple explicit estimators, these estimators turn out to be nearly as efficient as the best linear unbiased estimators and the maximum likelihood estimators. Next, we derive the asymptotic variances and covariance of these estimators in terms of the first two single moments and the product moments of order statistics from the standard extreme value distribution. Finally, we present an example in order to illustrate all the methods of estimation of parameters discussed in this paper.     

P-value adjustment for multiple binary endpoints

The p-value-based adjustment of individual endpoints and the global test for an overall inference are the two general approaches for the analysis of multiple endpoints. Statistical procedures developed for testing multivariate outcomes often assume that the multivariate endpoints are either independent or normally distributed. This paper presents a general approach for the analysis of multivariate binary data under the framework of generalized linear models. The generalized estimating equations (GEE) approach is applied to estimate the correlation matrix of the test statistics using the identity and exchangeable working correlation matrices with the model-based as well as robust estimators. The objectives of the approaches are the adjustment of p-values of individual endpoints to identify the affected endpoints as well as the global test of an overall effect. A Monte Carlo simulation was conducted to evaluate the overall family wise error (FWE) rates of the single-step down p-value adjustment approach from two adjustment methods to three global test statistics. The p-value adjustment approach seems to control the FWE better than the global approach Applications of the proposed methods are illustrated by analyzing a carcinogenicity experiment designed to study the dose response trend for 10 tumor sites, and a developmental toxicity experiment with three malformation types: external, visceral, and skeletal.     

Rethinking the Univariate Approach to Panel Unit Root Testing: Using Covariates to Resolve the Incidental Trend Problem

In an influential article, Hansen showed that covariate augmentation can lead to substantial power gains when compared to univariate tests. In this article, we ask if this result extends also to the panel data context? The answer turns out to be yes, which is maybe not that surprising. What is surprising, however, is the extent of the power gain, which is shown to more than outweigh the well-known power loss in the presence of incidental trends. That is, the covariates have an order effect on the neighborhood around unity for which local asymptotic power is negligible.     

Model Averaging for Prediction With Fragmentary Data

ABSTRACT

One main challenge for statistical prediction with data from multiple sources is that not all the associated covariate data are available for many sampled subjects. Consequently, we need new statistical methodology to handle this type of “fragmentary data” that has become more and more popular in recent years. In this article, we propose a novel method based on the frequentist model averaging that fits some candidate models using all available covariate data. The weights in model averaging are selected by delete-one cross-validation based on the data from complete cases. The optimality of the selected weights is rigorously proved under some conditions. The finite sample performance of the proposed method is confirmed by simulation studies. An example for personal income prediction based on real data from a leading e-community of wealth management in China is also presented for illustration.     

MODELING THE LIFETIME OF LONGITUDINAL ELEMENTS

In the study of the stochastic behaviour of the lifetime of an element as a function of its length, it is often observed that the failure time (or lifetime) decreases as the length increases. In probabilistic terms, such an idea can be expressed as follows. Let T be the lifetime of a specimen of length x, so the survival function, which denotes the probability that an element of length x survives till time t, will be given by S_T (t, x) = P(T > t/α(x), where α(x) is a monotonically decreasing function. In particular, it is often assumed that T has a Weibull distribution. In this paper, we propose a generalization of this Weibull model by assuming that the distribution of T is Generalized gamma (GG). Since the GG model contains the Weibull, Gamma and Lognormal models as special and limiting cases, a GG regression model is an appropriate tool for describing the size effect on the lifetime and for selecting among the embedded models. Maximum likelihood estimates are obtained for the GG regression model with α(x) = cx^b . As a special case this provide an alternative to the usual approach to estimation for the GG distribution which involves reparametrization. Related parametric inference issues are addressed and illustrated using two experimental data sets. Some discussion of censored data is also provided.     

HAZARD RATE ESTIMATION FOR CENSORED DATA BY WAVELET METHODS

ABSTRACT

We study the estimation of a hazard rate function based on censored data by non-linear wavelet method. We provide an asymptotic formula for the mean integrated squared error (MISE) of nonlinear wavelet-based hazard rate estimators under randomly censored data. We show this MISE formula, when the underlying hazard rate function and censoring distribution function are only piecewise smooth, has the same expansion as analogous kernel estimators, a feature not available for the kernel estimators. In addition, we establish an asymptotic normality of the nonlinear wavelet estimator.