Robust bootstrap estimates in heteroscedastic semi-varying coefficient models and applications in analyzing Australia CPI data

This article deals with the estimation of the parametric component, which is of primary interest, in the heteroscedastic semi-varying coefficient models. Based on the bootstrap technique, we present a procedure for estimating the parameters, which can provide a reliable approximation to the asymptotic distribution of the profile least-square (PLS) estimator. Furthermore, a bootstrap-type estimator of covariance matrix is developed, which is proved to be a consistent estimator of the covariance matrix. Moreover, some simulation experiments are conducted to evaluate the finite sample performance for the proposed methodology. Finally, the Australia CPI dataset is analyzed to demonstrate the application of the methods.     

Empirical Likelihood Inference for the Rao‐Hartley‐Cochran Sampling Design

The Hartley‐Rao‐Cochran sampling design is an unequal probability sampling design which can be used to select samples from finite populations. We propose to adjust the empirical likelihood approach for the Hartley‐Rao‐Cochran sampling design. The approach proposed intrinsically incorporates sampling weights, auxiliary information and allows for large sampling fractions. It can be used to construct confidence intervals. In a simulation study, we show that the coverage may be better for the empirical likelihood confidence interval than for standard confidence intervals based on variance estimates. The approach proposed is simple to implement and less computer intensive than bootstrap. The confidence interval proposed does not rely on re‐sampling, linearization, variance estimation, design‐effects or joint inclusion probabilities.     

Empirical Bayes estimation in continuous one-parameter exponential families under associated samples

In this paper, we study the empirical Bayes (EB) estimation in continuous one-parameter exponential families under negatively associated (NA) samples and positively associated (PA) samples. Under certain regularity conditions, it is shown that the convergence rates of proposed EB estimators under NA or PA samples are the same as those of EB estimators under independent observations, which significantly improve the existing results in EB estimation under associated samples.     

菲利普斯曲线在中国的有效性研究

从基本的菲利普斯曲线理论出发,提出了新的适应性预期模型,并以此为基础建立附加预期的菲利普斯曲线方程,进而估计出我国近年来的自然失业率水平,由此证明了菲利普斯曲线在我国的有效性,并描述了预期因素对实际通货膨胀水平的影响。最后结合实证分析结果提出解决我国通货膨胀和失业问题的建议,如保证货币政策的连贯性、加强信息披露、解决结构性失业问题等。     

Revisiting retesting in the estimation of proportions by group testing

In the estimation of a proportion p by group testing (pooled testing), retesting of units within positive groups has received little attention due to the minimal gain in precision compared to testing additional units. If acquisition of additional units is impractical or too expensive, and testing is not destructive, we show that retesting can be a useful option. We propose the retesting of a random grouping of units from positive groups, and compare it with nested halving procedures suggested by others. We develop an estimator of p for our proposed method, and examine its variance properties. Using simulation we compare retesting methods across a range of group testing situations, and show that for most realistic scenarios, our method is more efficient.     

Wavelet Estimator in Nonparametric Regression Model with Dependent Error’s Structure

In this article, we consider a nonparametric regression model with replicated observations based on the dependent error’s structure, for exhibiting dependence among the units. The wavelet procedures are developed to estimate the regression function. The moment consistency, the strong consistency, strong convergence rate and asymptotic normality of wavelet estimator are established under suitable conditions. A simulation study is undertaken to assess the finite sample performance of the proposed method.     

Estimating the population proportion in modified ranked set sampling methods

In this paper, proportion estimators and associated variance estimators are proposed for a binary variable with a concomitant variable based on modified ranked set sampling methods, which are extreme ranked set sampling (ERSS), median ranked set sampling (MRSS), percentile ranked set sampling (Per-RSS) and L ranked set sampling (LRSS) methods. The Monte Carlo simulation study is performed to compare the performance of the estimators based on bias, mean squared error, and relative efficiency for different levels of correlation coefficient, set and cycle sizes under normal and log-normal distributions. Moreover, the study is supported with real data application.     

Development of predictive signatures for treatment selection in precision medicine with survival outcomes

For survival endpoints in subgroup selection, a score conversion model is often used to convert the set of biomarkers for each patient into a univariate score and using the median of the univariate scores to divide the patients into biomarker‐positive and biomarker‐negative subgroups. However, this may lead to bias in patient subgroup identification regarding the 2 issues: (1) treatment is equally effective for all patients and/or there is no subgroup difference; (2) the median value of the univariate scores as a cutoff may be inappropriate if the sizes of the 2 subgroups are differ substantially. We utilize a univariate composite score method to convert the set of patient's candidate biomarkers to a univariate response score. We propose applying the likelihood ratio test (LRT) to assess homogeneity of the sampled patients to address the first issue. In the context of identification of the subgroup of responders in adaptive design to demonstrate improvement of treatment efficacy (adaptive power), we suggest that subgroup selection is carried out if the LRT is significant. For the second issue, we utilize a likelihood‐based change‐point algorithm to find an optimal cutoff. Our simulation study shows that type I error generally is controlled, while the overall adaptive power to detect treatment effects sacrifices approximately 4.5% for the simulation designs considered by performing the LRT; furthermore, the change‐point algorithm outperforms the median cutoff considerably when the subgroup sizes differ substantially.     

Response‐adaptive designs for binary responses: How to offer patient benefit while being robust to time trends?

Response‐adaptive randomisation (RAR) can considerably improve the chances of a successful treatment outcome for patients in a clinical trial by skewing the allocation probability towards better performing treatments as data accumulates. There is considerable interest in using RAR designs in drug development for rare diseases, where traditional designs are not either feasible or ethically questionable. In this paper, we discuss and address a major criticism levelled at RAR: namely, type I error inflation due to an unknown time trend over the course of the trial. The most common cause of this phenomenon is changes in the characteristics of recruited patients—referred to as patient drift. This is a realistic concern for clinical trials in rare diseases due to their lengthly accrual rate. We compute the type I error inflation as a function of the time trend magnitude to determine in which contexts the problem is most exacerbated. We then assess the ability of different correction methods to preserve type I error in these contexts and their performance in terms of other operating characteristics, including patient benefit and power. We make recommendations as to which correction methods are most suitable in the rare disease context for several RAR rules, differentiating between the 2‐armed and the multi‐armed case. We further propose a RAR design for multi‐armed clinical trials, which is computationally efficient and robust to several time trends considered.