An analytic method for randomized trials with informative censoring: Part 1

Consider a randomized trial in which time to the occurrence of a particular disease, say pneumocystis pneumonia in an AIDS trial or breast cancer in a mammographic screening trial, is the failure time of primary interest. Suppose that time to disease is subject to informative censoring by the minimum of time to death, loss to and end of follow-up. In such a trial, the censoring time is observed for all study subjects, including failures. In the presence of informative censoring, it is not possible to consistently estimate the effect of treatment on time to disease without imposing additional non-identifiable assumptions. The goals of this paper are to specify two non-identifiable assumptions that allow one to test for and estimate an effect of treatment on time to disease in the presence of informative censoring. In a companion paper (Robins, 1995), we provide consistent and reasonably efficient semiparametric estimators for the treatment effect under these assumptions. In this paper we largely restrict attention to testing. We propose tests that, like standard weighted-log-rank tests, are asymptotically distribution-free -level tests under the null hypothesis of no causal effect of treatment on time to disease whenever the censoring and failure distributions are conditionally independent given treatment arm. However, our tests remain asymptotically distribution-free -level tests in the presence of informative censoring provided either of our assumptions are true. In contrast, a weighted log-rank test will be an -level test in the presence of informative censoring only if (1) one of our two non-identifiable assumptions hold, and (2) the distribution of time to censoring is the same in the two treatment arms. We also extend our methods to studies of the effect of a treatment on the evolution over time of the mean of a repeated measures outcome, such as CD-4 count.     

Estimation for Continuous Branching Processes

The maximum-likelihood estimator for the curved exponential family given by continuous branching processes with immigration is investigated. These processes originated from population biology but also model the dynamics of interest rates and development of the state of technology in economics. It is proved that in contrast to branching processes with discrete space and/or time the MLE gives a unified approach to the inference. In order to include singular subdomains of the parameter space we modify the MLE slightly. Consistency and asymptotic normality for the MLE are considered. Concerning the asymptotic theory of the experiments, all three properties LAQ, LAN, and LAMN occur for different submodels     

A Class of Efficient Non-parametric K-sample Tests for Multivariate Counting Processes with Frailties

A K -sample testing problem is studied for multivariate counting processes with time-dependent frailty. Asymptotic distributions and efficiency of a class of non-parametric test statistics are established for certain local alternatives. The concept of efficiency is to show that for every non-parametric test in this class, there is a parametric submodel for which the optimal test has the same asymptotic power as the non-parametric one. The theory is applied to analyse a diabetic retinopathy study data set. A simulation study is also presented to illustrate the theory     

Efficient Estimation of a Distribution Function under Quadrant Dependence

LetX₁,X₂, ..., be real-valued random variables forming a strictly stationary sequence, and satisfying the basic requirement of being either pairwise positively quadrant dependent or pairwise negatively quadrant dependent. LetF^ be the marginal distribution function of theX_ips, which is estimated by the empirical distribution functionF_n and also by a smooth kernel-type estimateF_n, by means of the segmentX₁, ...,X_n. These estimates are compared on the basis of their mean squared errors (MSE). The main results of this paper are the following. Under certain regularity conditions, the optimal bandwidth (in the MSE sense) is determined, and is found to be the same as that in the independent identically distributed case. It is also shown thatn MSE(F_n(t)) andnMSE (F^_n(t)) tend to the same constant, asn→∞ so that one can not discriminate be tween the two estimates on the basis of the MSE. Next, ifi(n) = min {k∈{1, 2, ...}; MSE (F_k(t)) ≤ MSE (F_n(t))}, then it is proved thati(n)/n tends to 1, asn→∞. Thus, once again, one can not choose one estimate over the other in terms of their asymptotic relative efficiency. If, however, the squared bias ofF^_n(t) tends to 0 sufficiently fast, or equivalently, the bandwidthh_n satisfies the requirement thatnh³_n→ 0, asn→∞, it is shown that, for a suitable choice of the kernel, (i(n) ?n)/(nh_n) tends to a positive number, asn→∞ It follows that the deficiency ofF_n(t) with respect toF^_n(t),i(n) ?n, is substantial, and, actually, tends to ∞, asn→∞. In terms of deficiency, the smooth estimateF^_n(t) is preferable to the empirical distribution functionF_n(t)     

Uniform asymptotic linearity of a process based on a signed rank statistic

Consider the process with, cf. (1.2) on page 265 in B1, X₁, …, X_N a sample from a distribution F and, for i = 1, …, N, R${}_{\text{|x}{}_{\text{1}}\text{, - q}{}_{\text{1}}\text{ø|}}$ , the rank of |X₁ - q₁ø| among |X₁ - q₁ø|, …, |X_N - q_Nø|. It is shown that, under certain regularity conditions on F and on the constants p_i and q_i, T^ø_N(t) is asymptotically approximately a linear function of ø uniformly in t and in ø for |ø| ≤ C. The special case where the p_i and the q_i, are independent of i is considered.     

预设推理与语篇情景组合模式

预设推理是一种以读者经验争认知结构为基础的认知活动.对语篇语义的理解,既需要读者解读语言因素又需要读者的非语言因素的参与,即与语篇相关的预设推理.语篇情景组合就是作者利用先前存入的知识以及认知能力并与文本中的符号产生联系,以互明的认知情境为栽体,在话语之间建构最佳关联,以取得最大语境效果,创设情景的心理认知过程.文章拟从读者在解读语篇时所采用的预设推理方法以及作者在建构语篇时所采用的语篇情景组合模式两方面来探讨含义推导的心理认知过程.     

加权复合分位数回归方法在动态VaR风险度量中的应用

风险价值(VaR)因为简单直观,成为了当今国际上最主流的风险度量方法之一,而基于时间序列自回归(AR)模型来计算无条件风险度量值在实业界有广泛应用。本文基于分位数回归理论对AR模型提出了一个估计方法--加权复合分位数回归(WCQR)估计,该方法可以充分利用多个分位数信息提高参数估计的效率,并且对于不同的分位数回归赋予不同的权重,使得估计更加有效,文中给出了该估计的渐近正态性质。有限样本的数值模拟表明,当残差服从非正态分布时,WCQR估计的的统计性质接近于极大似然估计,而该估计是不需要知道残差分布的,因此,所提出的WCQR估计更加具有竞争力。此方法在预测资产收益的VaR动态风险时有较好的应用,我们将所提出的理论分析了我国九只封闭式基金,实证分析发现,结合WCQR方法求得的VaR风险与用非参数方法求得的VaR风险非常接近,而结合WCQR方法可以计算动态的VaR风险值和预测资产收益的VaR风险值。     

生存分析与股指涨跌的概率推断

通过研究上证指数连涨连跌的收益率,发现其服从伽玛分布,并且可得出股指涨跌的条件概率,以及极值时的情况,进一步研究了成交量的影响,从而说明了技术分析特别是价量分析为何在实际中仍然被广泛运用.可认为随机游动假说是一种粗糙的近似,本研究也有助于加深对市场有效性理论的认识.     

中国宪法非讼化原因探析

中国宪法呈现为非讼化特征是有其历史必然性的。其主要原因在于 :前苏联宪法模式及其苏维埃宪法意识的影响 ,宪法章程化、宪法纲领化和宪法问题政治化等中国现代宪法观念的作用 ,以及中国社会民主意识和公民宪法权利意识的限制     

Testing for No Effect by Cosine Series Methods

The properties of three lack-of-fit tests that are related to non-parametric cosine regression analysis are examined in the context of testing for a constant mean function. Analytic power comparisons of these tests vs a most powerful test are made using intermediate asymptotic relative efficiency. In particular, a data-driven test is produced which is asymptotically as efficient as the most powerful test over a class of alternatives. A small scale simulation experiment is conducted to ascertain the extent that the large sample comparisons are applicable to finite samples.