Exact inference for a simple step-stress model with competing risks for failure from exponential distribution under Type-II censoring

In reliability analysis, accelerated life-testing allows for gradual increment of stress levels on test units during an experiment. In a special class of accelerated life tests known as step-stress tests, the stress levels increase discretely at pre-fixed time points, and this allows the experimenter to obtain information on the parameters of the lifetime distributions more quickly than under normal operating conditions. Moreover, when a test unit fails, there are often more than one fatal cause for the failure, such as mechanical or electrical. In this article, we consider the simple step-stress model under Type-II censoring when the lifetime distributions of the different risk factors are independently exponentially distributed. Under this setup, we derive the maximum likelihood estimators (MLEs) of the unknown mean parameters of the different causes under the assumption of a cumulative exposure model. The exact distributions of the MLEs of the parameters are then derived through the use of conditional moment generating functions. Using these exact distributions as well as the asymptotic distributions and the parametric bootstrap method, we discuss the construction of confidence intervals for the parameters and assess their performance through Monte Carlo simulations. Finally, we illustrate the methods of inference discussed here with an example.     

A Bayesian estimate of the concordance correlation coefficient with skewed data

Concordance correlation coefficient (CCC) is one of the most popular scaled indices used to evaluate agreement. Most commonly, it is used under the assumption that data is normally distributed. This assumption, however, does not apply to skewed data sets. While methods for the estimation of the CCC of skewed data sets have been introduced and studied, the Bayesian approach and its comparison with the previous methods has been lacking. In this study, we propose a Bayesian method for the estimation of the CCC of skewed data sets and compare it with the best method previously investigated. The proposed method has certain advantages. It tends to outperform the best method studied before when the variation of the data is mainly from the random subject effect instead of error. Furthermore, it allows for greater flexibility in application by enabling incorporation of missing data, confounding covariates, and replications, which was not considered previously. The superiority of this new approach is demonstrated using simulation as well as real‐life biomarker data sets used in an electroencephalography clinical study. The implementation of the Bayesian method is accessible through the Comprehensive R Archive Network. Copyright © 2015 John Wiley & Sons, Ltd.     

Joint modelling of longitudinal biomarker and gap time between recurrent events: copula-based dependence

In this paper, we will extend the joint model of longitudinal biomarker and recurrent event via copula function for accounting the dependence between the two processes. The general idea of joining separate processes by allowing model-specific random effect may come from different families distribution. It is a main advantage of the proposed method that a copula construction does not constrain the choice of marginal distributions of random effects. A maximum likelihood estimation with importance sampling technique as a simple and easy understanding method is employed to model inference. To evaluate and verify the validation of the proposed joint model, a bootstrapping method as a model-based resampling is developed. Our proposed joint model is also applied to pemphigus disease data for assessing the effect of biomarker trajectory on risk of recurrence.     

The likelihood ratio test for homogeneity in finite mixture models

The authors study the asymptotic behaviour of the likelihood ratio statistic for testing homogeneity in the finite mixture models of a general parametric distribution family. They prove that the limiting distribution of this statistic is the squared supremum of a truncated standard Gaussian process. The autocorrelation function of the Gaussian process is explicitly presented. A re‐sampling procedure is recommended to obtain the asymptotic p‐value. Three kernel functions, normal, binomial and Poisson, are used in a simulation study which illustrates the procedure.     

Saddlepoint-Based Bootstrap Inference for Quadratic Estimating Equations

Abstract.  We propose an easy to implement method for making small sample parametric inference about the root of an estimating equation expressible as a quadratic form in normal random variables. It is based on saddlepoint approximations to the distribution of the estimating equation whose unique root is a parameter's maximum likelihood estimator (MLE), while substituting conditional MLEs for the remaining (nuisance) parameters. Monotoncity of the estimating equation in its parameter argument enables us to relate these approximations to those for the estimator of interest. The proposed method is equivalent to a parametric bootstrap percentile approach where Monte Carlo simulation is replaced by saddlepoint approximation. It finds applications in many areas of statistics including, nonlinear regression, time series analysis, inference on ratios of regression parameters in linear models and calibration. We demonstrate the method in the context of some classical examples from nonlinear regression models and ratios of regression parameter problems. Simulation results for these show that the proposed method, apart from being generally easier to implement, yields confidence intervals with lengths and coverage probabilities that compare favourably with those obtained from several competing methods proposed in the literature over the past half-century.     

Estimating the number of clusters

Hartigan (1975) defines the number q of clusters in a d ‐variate statistical population as the number of connected components of the set {f > c}, where f denotes the underlying density function on R^d and c is a given constant. Some usual cluster algorithms treat q as an input which must be given in advance. The authors propose a method for estimating this parameter which is based on the computation of the number of connected components of an estimate of {f > c}. This set estimator is constructed as a union of balls with centres at an appropriate subsample which is selected via a nonparametric density estimator of f. The asymptotic behaviour of the proposed method is analyzed. A simulation study and an example with real data are also included.     

Bootstrap procedures in a spatial-temporal model

Two bootstrap procedures are introduced into the hybrid of the backfitting algorithm and the Cochrane–Orcutt procedure in the estimation of a spatial-temporal model. The use of time blocks of consecutive observations in resampling steps proved to be optimal in terms of stability and efficiency of estimates. Between iterations, there were minimal changes in the empirical distributions of the parameter estimates associated with the covariate and temporal effects indicating convergence of the algorithm. Crop yield data are used to illustrate the proposed methods.

The simulation study indicated that prediction error from the fitted model (estimated from either Method 1 or Method 2) is very low. Also, the prediction error is relatively robust to the number of spatial units and the number of time points.     

Obtaining prediction intervals for FARIMA processes using the sieve bootstrap

The sieve bootstrap (SB) prediction intervals for invertible autoregressive moving average (ARMA) processes are constructed using resamples of residuals obtained by fitting a finite degree autoregressive approximation to the time series. The advantage of this approach is that it does not require the knowledge of the orders, p and q, associated with the ARMA(p, q) model. Up until recently, the application of this method has been limited to ARMA processes whose autoregressive polynomials do not have fractional unit roots. The authors, in a 2012 publication, introduced a version of the SB suitable for fractionally integrated autoregressive moving average (FARIMA (p,d,q)) processes with 0<d<0.5 and established its asymptotic validity. Herein, we study the finite sample properties this new method and compare its performance against an older method introduced by Bisaglia and Grigoletto in 2001. The sieve bootstrap (SB) method is a numerically simpler alternative to the older method which requires the estimation of p, d, and q at every bootstrap step. Monte-Carlo simulation studies, carried out under the assumption of normal, mixture of normals, and exponential distributions for the innovations, show near nominal coverages for short-term and long-term SB prediction intervals under most situations. In addition, the sieve bootstrap method yields better coverage and narrower intervals compared to the Bisaglia–Grigoletto method in some situations, especially when the error distribution is a mixture of normals.     

Transformation and Smoothing in Sample Survey Data

Abstract. We consider model‐based prediction of a finite population total when a monotone transformation of the survey variable makes it appropriate to assume additive, homoscedastic errors. As the transformation to achieve this does not necessarily simultaneously produce an easily parameterized mean function, we assume only that the mean is a smooth function of the auxiliary variable and estimate it non‐parametrically. The back transformation of predictions obtained on the transformed scale introduces bias which we remove using smearing. We obtain an asymptotic expansion for the prediction error which shows that prediction bias is asymptotically negligible and the prediction mean‐squared error (MSE) using a non‐parametric model remains in the same order as when a parametric model is adopted. The expansion also shows the effect of smearing on the prediction MSE and can be used to compute the asymptotic prediction MSE. We propose a model‐based bootstrap estimate of the prediction MSE. The predictor produces competitive results in terms of bias and prediction MSE in a simulation study, and performs well on a population constructed from an Australian farm survey.