A Taguchi-based Kansei engineering study of mobile phones at product design stage

This article is aimed at applying Taguchi method in Kansei engineering and explores a way to integrate it into an industrial product design stage. Emotional customer needs are derived using Kansei image word pairs. The Taguchi-based approach is validated by a case study with mobile phones. Experimental work in implementing the proposed approach was able to suggest design attributes of a mobile phone that are essential to be considered at the product design stage to satisfy the customers’ expectations and hence to increase the company's sales.     

A pragmatic adaptive enrichment design for selecting the right target population for cancer immunotherapies

One of the challenges in the design of confirmatory trials is to deal with uncertainties regarding the optimal target population for a novel drug. Adaptive enrichment designs (AED) which allow for a data-driven selection of one or more prespecified biomarker subpopulations at an interim analysis have been proposed in this setting but practical case studies of AEDs are still relatively rare. We present the design of an AED with a binary endpoint in the highly dynamic setting of cancer immunotherapy. The trial was initiated as a conventional trial in early triple-negative breast cancer but amended to an AED based on emerging data external to the trial suggesting that PD-L1 status could be a predictive biomarker. Operating characteristics are discussed including the concept of a minimal detectable difference, that is, the smallest observed treatment effect that would lead to a statistically significant result in at least one of the target populations at the interim or the final analysis, respectively, in the setting of AED.     

Logistic retainment interval dose exploration design for Phase I clinical trials of cytotoxic agents

Phase I studies of a cytotoxic agent often aim to identify the dose that provides an investigator specified target dose-limiting toxicity (DLT) probability. In practice, an initial cohort receives a dose with a putative low DLT probability, and subsequent dosing follows by consecutively deciding whether to retain the current dose, escalate to the adjacent higher dose, or de-escalate to the adjacent lower dose. This article proposes a Phase I design derived using a Bayesian decision-theoretic approach to this sequential decision-making process. The design consecutively chooses the action that minimizes posterior expected loss where the loss reflects the distance on the log-odds scale between the target and the DLT probability of the dose that would be given to the next cohort under the corresponding action. A logistic model is assumed for the log odds of a DLT at the current dose with a weakly informative t-distribution prior centered at the target. The key design parameters are the pre-specified odds ratios for the DLT probabilities at the adjacent higher and lower doses. Dosing rules may be pre-tabulated, as these only depend on the outcomes at the current dose, which greatly facilitates implementation. The recommended default version of the proposed design improves dose selection relative to many established designs across a variety of scenarios.     

绿色理念在图书馆建筑中的体现——以南京工程学院逸夫图书信息中心为例

绿色图书馆是现代图书馆的发展趋势,它贯彻的是一种科学、健康、创新、可持续发展的理念.绿色图书馆建设首先要从建筑做起.绿色建筑在设计上主要包括五个因素:可持续发展、节水、节能、材料选择与室内环境质量.南京工程学院逸夫图书信息中心在选址、造型及色彩、节能、功能区域设置、智能化系统、无障碍设计等方面充分体现了绿色图书馆的理念,达到了人、建筑、自然的和谐统一.     

北京奥林匹克公园中心区地下交通联系通道地面建筑设计的思考

北京奥林匹克公园中心区地下交通联系通道地面建筑由于位置突出、功能要求苛刻,故方案选定十分慎重。本文通过分析上述方案设计过程,对如下几个理论问题进行了探讨：①通道地面建筑的主要类型和特点;②建筑设计一般原则在通道地面建筑设计中的具体运用,提出实现功能是设计的出发点,坚持不断创新是设计的核心,解决设计理念与实践的矛盾是设计的最基本原则;③结合园林景观设计理论,强调了通道地面建筑与周边环境的协调关系。文章目的是探讨建筑设计理论应如何具体指导设计实践。     

天麻中天麻素的提取工艺

目的考察影响天麻中天麻素的提取因素。方法采用正交试验法,以提取液中醇浸膏收率及天麻素的含量为考察指标。结果提取的最佳条件70℃下,用40%乙醇提取3次,每次2h,6倍量乙醇。结论所用工艺稳定可行。     

探讨素描与设计结合的“二位一体”教学理念

随着时代的发展,如何更好地搞好设计学科建设,是艺术教育的社会使命和责任。训练思维、发展能力,这已成为素描教学的核心思想。素描与设计概念结合的“二位一体”教学,是造型基础课在现代设计教学中的必然转变。可以从观察能力、语言能力、思维能力等几方面进行训练。     

浅析绿色设计在服装设计中的运用

服装的绿色设计要求设计师在进行设计的时候,在材料的选择和运用、设计风格的确立、部件化与功能性策略的使用等方面,呵护生态,节约资源,做到自然简约,舒适环保.     

探析营销时代报纸版式设计的美感表达

为了探析适应营销时代报纸版式设计的美感表达,运用了印刷制版技术、专业审美水平、设计理念等科学设计方法,理论联系实际地分析了现代报纸版面设计颠覆性的变化,这不单是新闻加艺术的关系,也不是传统意义的美化和装饰,而是建立在视觉科学、阅读规律、市场营销之上,对信息传达、视觉承载、阅读过程、整体形象、文化品位的完整设计,是一个以审美活动为对象,以美感经验为中介,研究美、审美和艺术创造的一般现象和普遍规律的一门科学,是科学与艺术结合的过程.     

需要薪酬——一种新型企业薪酬模式的探索与设计

随着市场经济的不断完善,企业在薪酬管理内容、管理模式等方面有了很大的发展,但受传统薪酬管理的影响,目前的薪酬模式尚存在许多不足之处。在这种情况下,以相关薪酬理论为支撑,并借鉴宽带薪酬的设计思想,探索一种新型薪酬模式——需要薪酬,表现出一定的必要性及价值性。