The Effect of Drop-Out on the Efficiency of Longitudinal Experiments

It is shown that drop-out often reduces the efficiency of longitudinal experiments considerably. In the framework of linear mixed models, a general, computationally simple method is provided, for designing longitudinal studies when drop-out is to be expected, such that there is little risk of large losses of efficiency due to the missing data. All the results are extensively illustrated using data from a randomized experiment with rats.     

Semiparametric Additive Accelerated Life Models

In this paper we investigate the asymptotic properties of estimators obtained for the semiparametric additive accelerated life model proposed by Bagdonavicius & Nikulin (1995). This model generalizes the well known additive hazards model of survival analysis and is close to the general transformation model (see Dabrowska & Doksum, 1988). Asymptotic properties of the estimator of the regression parameter and the estimator of the reliability function are given in the case of right censoring for discretized data and a numerical example illustrates these results.     

Kernel Density Estimation with Generalized Binning

We propose kernel density estimators based on prebinned data. We use generalized binning schemes based on the quantiles points of a certain auxiliary distribution function. Therein the uniform distribution corresponds to usual binning. The statistical accuracy of the resulting kernel estimators is studied, i.e. we derive mean squared error results for the closeness of these estimators to both the true function and the kernel estimator based on the original data set. Our results show the influence of the choice of the auxiliary density on the binned kernel estimators and they reveal that non-uniform binning can be worthwhile.     

吸烟对免疫功能的影响

本文就烟草在吸燃过程中产生的有害物质对免疫功能的影响,并阐述吸烟对人体的危害。     

DENSITY ESTIMATION FOR CLUSTERED DATA

The commonly used survey technique of clustering introduces dependence into sample data. Such data is frequently used in economic analysis, though the dependence induced by the sample structure of the data is often ignored. In this paper, the effect of clustering on the non-parametric, kernel estimate of the density, f(x), is examined. The window width commonly used for density estimation for the case of i.i.d. data is shown to no longer be optimal. A new optimal bandwidth using a higher-order kernel is proposed and is shown to give a smaller integrated mean squared error than two window widths which are widely used for the case of i.i.d. data. Several illustrations from simulation are provided.     

Statistical Analysis of Marginal Count Failure Data

Manufacturers want to assess the quality andreliability of their products. Specifically, they want to knowthe exact number of failures from the sales transacted duringa particular month. Information available today is sometimesincomplete as many companies analyze their failure data simplycomparing sales for a total month from a particular departmentwith the total number of claims registered for that given month.This information—called marginal count data—is, thus,incomplete as it does not give the exact number of failures ofthe specific products that were sold in a particular month. Inthis paper we discuss nonparametric estimation of the mean numbersof failures for repairable products and the failure probabilitiesfor nonrepairable products. We present a nonhomogeneous Poissonprocess model for repairable products and a multinomial modeland its Poisson approximation for nonrepairable products. A numericalexample is given and a simulation is carried out to evaluatethe proposed methods of estimating failure probabilities undera number of possible situations.     

A Multiple Imputation Approach to Linear Regression with Clustered Censored Data

Weextend Wei and Tanner's (1991) multiple imputation approach insemi-parametric linear regression for univariate censored datato clustered censored data. The main idea is to iterate the followingtwo steps: 1) using the data augmentation to impute for censoredfailure times; 2) fitting a linear model with imputed completedata, which takes into consideration of clustering among failuretimes. In particular, we propose using the generalized estimatingequations (GEE) or a linear mixed-effects model to implementthe second step. Through simulation studies our proposal comparesfavorably to the independence approach (Lee et al., 1993), whichignores the within-cluster correlation in estimating the regressioncoefficient. Our proposal is easy to implement by using existingsoftwares.     

Bayesian inference for generalized additive mixed models based on Markov random field priors

Most regression problems in practice require flexible semiparametric forms of the predictor for modelling the dependence of responses on covariates. Moreover, it is often necessary to add random effects accounting for overdispersion caused by unobserved heterogeneity or for correlation in longitudinal or spatial data. We present a unified approach for Bayesian inference via Markov chain Monte Carlo simulation in generalized additive and semiparametric mixed models. Different types of covariates, such as the usual covariates with fixed effects, metrical covariates with non-linear effects, unstructured random effects, trend and seasonal components in longitudinal data and spatial covariates, are all treated within the same general framework by assigning appropriate Markov random field priors with different forms and degrees of smoothness. We applied the approach in several case-studies and consulting cases, showing that the methods are also computationally feasible in problems with many covariates and large data sets. In this paper, we choose two typical applications.     

Case–control studies with complex sampling

The use of complex sampling designs in population-based case–control studies is becoming more common, particularly for sampling the control population. This is prompted by all the usual cost and logistical benefits that are conferred by multistage sampling. Complex sampling has often been ignored in analysis but, with the advent of packages like SUDAAN, survey-weighted analyses that take account of the sample design can be carried out routinely. This paper explores this approach and more efficient alternatives, which can also be implemented by using readily available software.     

Overcoming biases and misconceptions in ecological studies

The aggregate data study design provides an alternative group level analysis to ecological studies in the estimation of individual level health risks. An aggregate model is derived by aggregating a plausible individual level relative rate model within groups, such that population-based disease rates are modelled as functions of individual level covariate data. We apply an aggregate data method to a series of fictitious examples from a review paper by Greenland and Robins which illustrated the problems that can arise when using the results of ecological studies to make inference about individual health risks. We use simulated data based on their examples to demonstrate that the aggregate data approach can address many of the sources of bias that are inherent in typical ecological analyses, even though the limited between-region covariate variation in these examples reduces the efficiency of the aggregate study. The aggregate method has the potential to estimate exposure effects of interest in the presence of non-linearity, confounding at individual and group levels, effect modification, classical measurement error in the exposure and non-differential misclassification in the confounder.