Nearly optimal orthogonally blocked desings for a quadratic mixture model with q components

In experiments with mixtures involving process variables, orthogonal block designs may be used to allow estimation of the parameters of the mixture components independently of estimation of the parameters of the process variables. In the class of orthogonally blocked designs based on pairs of suitably chosen Latin squares, the optimal designs consist primarily of binary blends of the mixture components, regardless of how many ingredients are available for the mixture. This paper considers ways of modifying these optimal designs so that some or all of the runs used in the experiment include a minimum proportion of each mixture ingredient. The designs considered are nearly optimal in the sense that the experimental points are chosen to follow ridges of maxima in the optimality criteria. Specific designs are discussed for mixtures involving three and four components and distinctions are identified for different designs with the same optimality properties. The ideas presented for these specific designs are readily extended to mixtures with q>4 components.     

Balanced Factorial Designs for cDNA Microarray Experiments

Balanced factorial designs are introduced for cDNA microarray experiments. Single replicate designs obtained using the classical method of confounding are shown to be particularly useful for deriving suitable balanced designs for cDNA microarrays. Classical factorial designs obtained using methods other than the method of confounding are also shown to be useful. The paper provides a systematic method of deriving designs for microarray experiments as opposed to algorithmic and ad-hoc methods and generalizes several of the microarray designs given recently in the literature.     

Optimum Mixture Design Using Deficiency Criterion

In a mixture experiment the measured response is assumed to depend only on the relative proportion of ingredients or components present in the mixture. Scheffe (1958 Scheffe , H. ( 1958 ). Experiments with mixtures . J. R. Statist. Soc. B 20 : 344 – 360 . [Google Scholar], 1963 Scheffe , H. ( 1963 ). Simplex – centroid design for experiments with mixtures . J. R. Statist. Soc. B 25 : 235 – 263 . [Google Scholar]) first systematically considered this problem and introduced different models and designs suitable in such situations. Optimum designs for the estimation of parameters of different mixture models are available in the literature. The problem of estimating the optimum proportion of mixture components is of great practical importance. Pal and Mandal (2006 Pal , M. , Mandal , N. K. ( 2006 ). Optimum designs for optimum mixtures . Statist. Probab. Lett. 76 ( 13 ): 1369 – 1379 .[Crossref], [Web of Science ®] , [Google Scholar], 2007 Pal , M. , Mandal , N. K. (2007). Optimum mixture design via equivalence theory. communicated. JCISS 32:107–126. [Google Scholar]) attempted to find a solution to this problem by adopting a pseudo-Bayesian approach and using the trace criterion. Subsequently, Pal and Mandal (2008 Pal , M. , Mandal , N. K. ( 2008 ). Minimax designs for optimum mixtures . To appear in Statist. Probab. Lett.  [Google Scholar]) solved the problem using minimax criterion. In this article, the deficiency criterion due to Chatterjee and Mandal (1981 Chatterjee , S. K. , Mandal , N. K. ( 1981 ). Response surface designs for estimating the optimal point . Calcutta Statist. Assoc. Bull. . 30 : 145 – 169 .[Crossref] , [Google Scholar]) has been used as a measure for comparing the performance of competing designs.     

New Statistic to Increase Correctness in Simulation Factor Screening Using Frequency Domain Method

Simulation models often include a large number of input factors, many of them may be unimportant to the output; justifying the use of factor screening experiments to eliminate unimportant input factors from consideration in later stages of analysis. With a large number of factors, the challenge is designing experiments so that total number of runs and consequently the required time and cost decrease while achieving a satisfactory detection rate. This article employs frequency domain method (FDM) which is applicable in discrete-event simulation models to propose a new statistic defined as the ratio of estimated signal spectrum to maximum estimated noise spectrum. The proposed method not only has the FDM advantages compared to classic screening approaches but also helps to reduce the error of associated with distinguishing important effects from unimportant ones. Furthermore, as an alternative to the existing statistics, it is shown that not only the proposed statistic does not deteriorate the power of the screening test but in some instances it helps to improve it.     

The use of a reference variety for comparisons in incomplete series of crop variety trials

In a series of crop variety trials, ‘test varieties’ are compared with one another and with a ‘reference’ variety that is included in all trials. The series is typically analyzed with a linear mixed model and the method of generalized least squares. Usually, the estimates of the expected differences between the test varieties and the reference variety are presented. When the series is incomplete, i.e. when all test varieties were not included in all trials, the method of generalized least squares may give estimates of expected differences to the reference variety that do not appear to accord with observed differences. The present paper draws attention to this phenomenon and explores the recurrent idea of comparing test varieties indirectly through the use of the reference. A new ‘reference treatment method’ was specified and compared with the method of generalized least squares when applied to a five-year series of 85 spring wheat trials. The reference treatment method provided estimates of differences to the reference variety that agreed with observed differences, but was considerably less efficient than the method of generalized least squares.     

Clustering Effects in Unreplicated Factorial Experiments

The analysis of unreplicated factorial designs concentrates much attention since there are no degrees of freedom left to estimate the error variance. In this article, we propose clustering the factorial estimates in two groups, one containing the active effects and one containing the inactive effects. The powerfulness of the proposed method is revealed via a comparative simulation study.     

基于的教学一体化工作平台的研究与实现

探讨了部队院校教学中存在的问题,并针对这些问题提出了基于教师、学生、学生管理者的双监督的教学管理模式。根据该模式给出了基于CSCW的教学一体化工作平台的构建方案,并介绍了其主要功能和实现的关键技术,为网络教学系统的软件实现提供了一个良好的解决方案。     

高校计算机基础教育面临的问题及改进措施

新生入学时计算机知识差异性很大,针对此问题应开展分层教学,改革教学思路,并在基础教学中大力提倡＂精讲多练＂,从而全面地对学生的基本素质和思维方式进行培养。     

浅析计算机管理固定资产

在新形势下,固定资产的地位越来越重要,随着计算机技术的发展,人们开始应用计算机技术进行资产的管理。本文提出计算机软件科学管理固定资产理念并介绍其具体应用过程。     

基于计算机和网络的大学英语教学中教师角色的再定位

计算机和网络技术的发展为大学英语教学带来了新的机遇和挑战。传统的教师角色已不再适应当前大学英语教学的发展需要。大学英语教师应该以建构主义为指导,结合大学英语教学改革的方向,主动转变观念,实现大学英语教师在新的教学模式下的角色转换。