Bootstrap test of hypothesis for the multi-state models in survival analysis

Abstract

In the present paper we develop bootstrap tests of hypothesis, based on simulation, for the transition probability matrix arising in the context of a multi-state model. The bootstrap test statistic is based on the paper of Tattar and Vaman (2008 Tattar, P. N., Vaman, H. J. (2008). Testing transition probability matrix of a multi-state model with censored data. Lifetime Data Anal. 14(2):216–230.[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]), which develops a statistic for the testing problems concerning the transition probability matrix of the non homogeneous Markov process.     

A model with long-term survivors: negative binomial Birnbaum-Saunders

Abstract

We propose a cure rate survival model by assuming that the number of competing causes of the event of interest follows the negative binomial distribution and the time to the event of interest has the Birnbaum-Saunders distribution. Further, the new model includes as special cases some well-known cure rate models published recently. We consider a frequentist analysis for parameter estimation of the negative binomial Birnbaum-Saunders model with cure rate. Then, we derive the appropriate matrices for assessing local influence on the parameter estimates under different perturbation schemes. We illustrate the usefulness of the proposed model in the analysis of a real data set from the medical area.     

Exponential Inequalities in Stochastic Inverse Problems Using an Iterative Method

We consider an iterative method in order to solve linear inverse problems. We establish exponential inequalities for the probability of the distance between the approximated solution and the exact one for a calibration problem. The approximate is given by an iterative method with Gaussian errors. We treat an operator equation of the form Ax = u, where A is a compact operator.     

Test for periodicity in restrictive EXPAR models

Abstract

This article is devoted to study the problem of test of periodicity in the restricted exponential autoregressive (EXPAR) model. The local asymptotic normality property, of this model, is shown via the adapted sufficient conditions due to Swensen (1985 Swensen, A.R. (1985). The asymptotic distribution of the likelihood ratio for autoregressive time series with a regression trend. J. Multivariate Anal. 16:54–70.[Crossref], [Web of Science ®] , [Google Scholar]). Using this result, in the case where the innovation density is specified, we obtain a parametric local asymptotic “most stringent” test.     

A proportional hazards model for the analysis of doubly censored competing risks data

ABSTRACT

Competing risks data are common in medical research in which lifetime of individuals can be classified in terms of causes of failure. In survival or reliability studies, it is common that the patients (objects) are subjected to both left censoring and right censoring, which is refereed as double censoring. The analysis of doubly censored competing risks data in presence of covariates is the objective of this study. We propose a proportional hazards model for the analysis of doubly censored competing risks data, using the hazard rate functions of Gray (1988 Gray, R.J. (1988). A class of k-sample tests for comparing the cumulative incidence of a competing risk. Ann. Statist. 16:1141–1154.[Crossref], [Web of Science ®] , [Google Scholar]), while focusing upon one major cause of failure. We derive estimators for regression parameter vector and cumulative baseline cause specific hazard rate function. Asymptotic properties of the estimators are discussed. A simulation study is conducted to assess the finite sample behavior of the proposed estimators. We illustrate the method using a real life doubly censored competing risks data.     

Composite quantile regression for varying-coefficient single-index models

ABSTRACT

The varying-coefficient single-index model (VCSIM) is a very general and flexible tool for exploring the relationship between a response variable and a set of predictors. Popular special cases include single-index models and varying-coefficient models. In order to estimate the index-coefficient and the non parametric varying-coefficients in the VCSIM, we propose a two-stage composite quantile regression estimation procedure, which integrates the local linear smoothing method and the information of quantile regressions at a number of conditional quantiles of the response variable. We establish the asymptotic properties of the proposed estimators for the index-coefficient and varying-coefficients when the error is heterogeneous. When compared with the existing mean-regression-based estimation method, our simulation results indicate that our proposed method has comparable performance for normal error and is more robust for error with outliers or heavy tail. We illustrate our methodologies with a real example.     

Detection of outliers in mixed regressive-spatial autoregressive models

ABSTRACT

This article studies the outlier detection problem in mixed regressive-spatial autoregressive model. The formulae for testing outliers and their approximate distributions are derived under the mean-shift model and the variance-weight model, respectively. The simulation studies are conducted for examining the power and size of the test, as well as for the detection of outliers when a simulated data contains several outliers. A real data is analyzed to illustrate the proposed method, and modified models based on mean-shift and variance-weight models in which detected outliers are taken into account are suggested to deal with the outliers and confirm theconclusions.     

Regression Analysis of Left-truncated and Case I Interval-censored Data with the Additive Hazards Model

In recent years the analysis of interval-censored failure time data has attracted a great deal of attention and such data arise in many fields including demographical studies, economic and financial studies, epidemiological studies, social sciences, and tumorigenicity experiments. This is especially the case in medical studies such as clinical trials. In this article, we discuss regression analysis of one type of such data, Case I interval-censored data, in the presence of left-truncation. For the problem, the additive hazards model is employed and the maximum likelihood method is applied for estimations of unknown parameters. In particular, we adopt the sieve estimation approach that approximates the baseline cumulative hazard function by linear functions. The resulting estimates of regression parameters are shown to be consistent and efficient and have an asymptotic normal distribution. An illustrative example is provided.     

Uniform asymptotics for ruin probability of a two-dimensional dependent renewal risk model

ABSTRACT

In this paper we consider the tail behavior of a two-dimensional dependent renewal risk model with two dependent classes of insurance business, in which the claim sizes are governed by a common renewal counting process, and their inter-arrival times are dependent, identically distributed. For the case that the claim size distribution belongs to the intersection of long-tailed distribution class and dominant variation class, we obtain an asymptotic formula, which holds uniformly for all time in an infinite interval. Moreover, we point out that the formula still holds uniformly for all time in an infinite interval for widely dependent random variables (r.v.s) under some conditions.