Conditional Inference With a Functional Nuisance Parameter

This paper shows that the problem of testing hypotheses in moment condition models without any assumptions about identification may be considered as a problem of testing with an infinite‐dimensional nuisance parameter. We introduce a sufficient statistic for this nuisance parameter in a Gaussian problem and propose conditional tests. These conditional tests have uniformly correct asymptotic size for a large class of models and test statistics. We apply our approach to construct tests based on quasi‐likelihood ratio statistics, which we show are efficient in strongly identified models and perform well relative to existing alternatives in two examples.     

A Test for Instrument Validity

This paper develops a specification test for instrument validity in the heterogeneous treatment effect model with a binary treatment and a discrete instrument. The strongest testable implication for instrument validity is given by the condition for nonnegativity of point‐identifiable compliers' outcome densities. Our specification test infers this testable implication using a variance‐weighted Kolmogorov–Smirnov test statistic. The test can be applied to both discrete and continuous outcome cases, and an extension of the test to settings with conditioning covariates is provided.     

Linear Increments with Non‐monotone Missing Data and Measurement Error

Linear increments (LI) are used to analyse repeated outcome data with missing values. Previously, two LI methods have been proposed, one allowing non‐monotone missingness but not independent measurement error and one allowing independent measurement error but only monotone missingness. In both, it was suggested that the expected increment could depend on current outcome. We show that LI can allow non‐monotone missingness and either independent measurement error of unknown variance or dependence of expected increment on current outcome but not both. A popular alternative to LI is a multivariate normal model ignoring the missingness pattern. This gives consistent estimation when data are normally distributed and missing at random (MAR). We clarify the relation between MAR and the assumptions of LI and show that for continuous outcomes multivariate normal estimators are also consistent under (non‐MAR and non‐normal) assumptions not much stronger than those of LI. Moreover, when missingness is non‐monotone, they are typically more efficient.     

Bayesian Conditional Mean Estimation in Log‐Normal Linear Regression Models with Finite Quadratic Expected Loss

Log‐normal linear regression models are popular in many fields of research. Bayesian estimation of the conditional mean of the dependent variable is problematic as many choices of the prior for the variance (on the log‐scale) lead to posterior distributions with no finite moments. We propose a generalized inverse Gaussian prior for this variance and derive the conditions on the prior parameters that yield posterior distributions of the conditional mean of the dependent variable with finite moments up to a pre‐specified order. The conditions depend on one of the three parameters of the suggested prior; the other two have an influence on inferences for small and medium sample sizes. A second goal of this paper is to discuss how to choose these parameters according to different criteria including the optimization of frequentist properties of posterior means.     

On conditional risk estimation considering model risk

Usually, parametric procedures used for conditional variance modelling are associated with model risk. Model risk may affect the volatility and conditional value at risk estimation process either due to estimation or misspecification risks. Hence, non-parametric artificial intelligence models can be considered as alternative models given that they do not rely on an explicit form of the volatility. In this paper, we consider the least-squares support vector regression (LS-SVR), weighted LS-SVR and Fixed size LS-SVR models in order to handle the problem of conditional risk estimation taking into account issues of model risk. A simulation study and a real application show the performance of proposed volatility and VaR models.     

以目的与背景知识为双条件的逻辑AKC

首先,我们构造以目的和背景知识为双条件的条件句系统AKC,给出它的一些证明论结果。其次,我们引入有序邻域语义,给出描述AKC的特征公理和推理规则的框架条件,证明AKC相对这些框架条件是框架可靠的。最后,我们证明AKC相对这些框架条件也是框架完全的。     

Model selection in high-dimensional noisy data: a simulation study

In many practical applications, high-dimensional regression analyses have to take into account measurement error in the covariates. It is thus necessary to extend regularization methods, that can handle the situation where the number of covariates p largely exceed the sample size n, to the case in which covariates are also mismeasured. A variety of methods are available in this context, but many of them rely on knowledge about the measurement error and the structure of its covariance matrix. In this paper, we set the goal to compare some of these methods, focusing on situations relevant for practical applications. In particular, we will evaluate these methods in setups in which the measurement error distribution and dependence structure are not known and have to be estimated from data. Our focus is on variable selection, and the evaluation is based on extensive simulations.     

Empirical evaluation of the implementation of the EMA guideline on missing data in confirmatory clinical trials: Specification of mixed models for longitudinal data in study protocols

In confirmatory clinical trials, the prespecification of the primary analysis model is a universally accepted scientific principle to allow strict control of the type I error. Consequently, both the ICH E9 guideline and the European Medicines Agency (EMA) guideline on missing data in confirmatory clinical trials require that the primary analysis model is defined unambiguously. This requirement applies to mixed models for longitudinal data handling missing data implicitly. To evaluate the compliance with the EMA guideline, we evaluated the model specifications in those clinical study protocols from development phases II and III submitted between 2015 and 2018 to the Ethics Committee at Hannover Medical School under the German Medicinal Products Act, which planned to use a mixed model for longitudinal data in the confirmatory testing strategy. Overall, 39 trials from different types of sponsors and a wide range of therapeutic areas were evaluated. While nearly all protocols specify the fixed and random effects of the analysis model (95%), only 77% give the structure of the covariance matrix used for modeling the repeated measurements. Moreover, the testing method (36%), the estimation method (28%), the computation method (3%), and the fallback strategy (18%) are given by less than half the study protocols. Subgroup analyses indicate that these findings are universal and not specific to clinical trial phases or size of company. Altogether, our results show that guideline compliance is to various degrees poor and consequently, strict type I error rate control at the intended level is not guaranteed.     

考虑零售商质量控制和风险规避的供应链网络均衡研究

研究零售商质量控制和供应链成员风险规避背景下供应链网络均衡问题。应用条件风险值度量风险规避程度,利用变分不等式理论描绘供应链参与者的最优经济行为,设计供应链网络均衡模型,考虑风险规避和质量控制策略对均衡的影响,证明均衡解存在且唯一,并运用Levenberg-Marquardt算法求解均衡模型。最后对重要参数进行数值分析,揭示质量控制和风险规避对供应链均衡解以及参与者条件风险值的影响。研究表明：供应链参与者越规避风险越有利于产品质量水平的提高,风险规避程度的加深会降低制造商或零售商自身的CVaR,同时增大对方的CVaR,对因产品合格率提高带来的利益而言,制造商所得优于零售商。