A permutation approach for testing heterogeneity in two-sample categorical variables

In many sciences researchers often meet the problem of establishing if the distribution of a categorical variable is more concentrated, or less heterogeneous, in population P ₁ than in population P ₂. An approximate nonparametric solution to this problem is discussed within the permutation context. Such a solution has similarities to that of testing for stochastic dominance, that is, of testing under order restrictions, for ordered categorical variables. Main properties of given solution and a Monte Carlo simulation in order to evaluate its degree of approximation and its power behaviour are examined. Two application examples are also discussed.     

Use of log−log survival function in modeling time-covariate interactions in Cox regression

Plotting of log−log survival functions against time for different categories or combinations of categories of covariates is perhaps the easiest and most commonly used graphical tool for checking proportional hazards (PH) assumption. One problem in the utilization of the technique is that the covariates need to be categorical or made categorical through appropriate grouping of the continuous covariates. Subjectivity in the decision making on the basis of eye-judgment of the plots and frequent inconclusiveness arising in situations where the number of categories and/or covariates gets larger are among other limitations of this technique. This paper proposes a non-graphical (numerical) test of the PH assumption that makes use of log−log survival function. The test enables checking proportionality for categorical as well as continuous covariates and overcomes the other limitations of the graphical method. Observed power and size of the test are compared to some other tests of its kind through simulation experiments. Simulations demonstrate that the proposed test is more powerful than some of the most sensitive tests in the literature in a wide range of survival situations. An example of the test is given using the widely used gastric cancer data.     

A new alternative to the standard F test for clustered data

The data collection process and the inherent population structure are the main causes for clustered data. The observations in a given cluster are correlated, and the magnitude of such correlation is often measured by the intra-cluster correlation coefficient. The intra-cluster correlation can lead to an inflated size of the standard F test in a linear model. In this paper, we propose a solution to this problem. Unlike previous adjustments, our method does not require estimation of the intra-class correlation, which is problematic especially when the number of clusters is small. Our simulation results show that the new method outperforms the existing methods.     

Confidence interval estimation of the difference between paired AUCs based on combined biomarkers

In many diagnostic studies, multiple diagnostic tests are performed on each subject or multiple disease markers are available. Commonly, the information should be combined to improve the diagnostic accuracy. We consider the problem of comparing the discriminatory abilities between two groups of biomarkers. Specifically, this article focuses on confidence interval estimation of the difference between paired AUCs based on optimally combined markers under the assumption of multivariate normality. Simulation studies demonstrate that the proposed generalized variable approach provides confidence intervals with satisfying coverage probabilities at finite sample sizes. The proposed method can also easily provide P-values for hypothesis testing. Application to analysis of a subset of data from a study on coronary heart disease illustrates the utility of the method in practice.     

Modified inference about the mean of the exponential distribution using moving extreme ranked set sampling

The maximum likelihood estimator (MLE) and the likelihood ratio test (LRT) will be considered for making inference about the scale parameter of the exponential distribution in case of moving extreme ranked set sampling (MERSS). The MLE and LRT can not be written in closed form. Therefore, a modification of the MLE using the technique suggested by Maharota and Nanda (Biometrika 61:601–606, 1974) will be considered and this modified estimator will be used to modify the LRT to get a test in closed form for testing a simple hypothesis against one sided alternatives. The same idea will be used to modify the most powerful test (MPT) for testing a simple hypothesis versus a simple hypothesis to get a test in closed form for testing a simple hypothesis against one sided alternatives. Then it appears that the modified estimator is a good competitor of the MLE and the modified tests are good competitors of the LRT using MERSS and simple random sampling (SRS).     

Approximate confidence intervals for the weighted kappa coefficient of a binary diagnostic test subject to a case–control design

Case–control design to assess the accuracy of a binary diagnostic test (BDT) is very frequent in clinical practice. This design consists of applying the diagnostic test to all of the individuals in a sample of those who have the disease and in another sample of those who do not have the disease. The sensitivity of the diagnostic test is estimated from the case sample and the specificity is estimated from the control sample. Another parameter which is used to assess the performance of a BDT is the weighted kappa coefficient. The weighted kappa coefficient depends on the sensitivity and specificity of the diagnostic test, on the disease prevalence and on the weighting index. In this article, confidence intervals are studied for the weighted kappa coefficient subject to a case–control design and a method is proposed to calculate the sample sizes to estimate this parameter. The results obtained were applied to a real example.     

Asymptotic behaviour of proportions of observations in random regions determined by central order statistics from stationary processes

In this paper, we show that proportions of observations that fall into a random region determined by a given Borel set and a central order statistic converge almost surely, provided that the corresponding population quantile is unique. We also describe three types of possible asymptotic behaviour of these proportions in the case of non-unique population quantile. As an application of our findings we establish limiting properties of numbers of ties with a central order statistics in a discrete sample. Our results are derived not only for independent and identically distributed observations but more generally for strictly stationary and ergodic sequences of random variables.     

Combined asymmetric spatial weights matrix with application to housing prices

In this study, a combined asymmetric spatial weights matrix is proposed for capturing the unequal spatial dependence of housing prices, where the advantage of this matrix was demonstrated by a non-nested hypothesis test. To explore the heterogeneous spatial impacts of urban essential characteristics on housing prices over the eastern, central, and western regions of China, after the Lagrange multiplier and likelihood ratio tests, the spatial Durbin model using the proposed weights matrix was applied to each region. The estimation results showed that the direct impacts of college and new employment were significantly negative in the eastern region, but not significant in the central and western regions. By contrast, the direct impacts of hospitals and scenic spots were significantly positive in eastern China, but not significant in central and western China. In addition, the indirect impacts of the four variables were not significant in the three regions. These results suggest that in eastern China, the government may increase the requirements for using medical resources and close tourist attractions in a single city to cool down the skyrocketing housing prices in this area.     

Tests for Structural Changes in Time Series of Counts

We propose methods for detecting structural changes in time series with discrete‐valued observations. The detector statistics come in familiar L2‐type formulations incorporating the empirical probability generating function. Special emphasis is given to the popular models of integer autoregression and Poisson autoregression. For both models, we study mainly structural changes due to a change in distribution, but we also comment for the classical problem of parameter change. The asymptotic properties of the proposed test statistics are studied under the null hypothesis as well as under alternatives. A Monte Carlo power study on bootstrap versions of the new methods is also included along with a real data example.