Simultaneous confidence band for the difference of segmented linear models

Consider comparing between two treatments a response variable, whose expectation depends on the value of a continuous covariate in some nonlinear fashion. We fit separate segmented linear models to each treatment to approximate the nonlinear relationship. For this setting, we provide a simultaneous confidence band for the difference between treatments of the expected value functions. The treatments are said to differ significantly on intervals of the covariate where the simultaneous confidence band does not contain zero. We consider segmented linear models where the locations of the changepoints are both known and unknown. The band is obtained from asymptotic results.     

Testing for qualitative interaction of multiple sources of informative dropout in longitudinal data

Longitudinal studies suffer from patient dropout. The dropout process may be informative if there exists an association between dropout patterns and the rate of change in the response over time. Multiple patterns are plausible in that different causes of dropout might contribute to different patterns. These multiple patterns can be dichotomized into two groups: quantitative and qualitative interaction. Quantitative interaction indicates that each of the multiple sources is biasing the estimate of the rate of change in the same direction, although with differing magnitudes. Alternatively, qualitative interaction results in the multiple sources biasing the estimate of the rate of change in opposing directions. Qualitative interaction is of special concern, since it is less likely to be detected by conventional methods and can lead to highly misleading slope estimates. We explore a test for qualitative interaction based on simultaneous confidence intervals. The test accommodates the realistic situation where reasons for dropout are not fully understood, or even entirely unknown. It allows for an additional level of clustering among participating subjects. We apply these methods to a study exploring tumor growth rates in mice as well as a longitudinal study exploring rates of change in cognitive functioning for Alzheimer's patients.     

Controlled Direct and Mediated Effects: Definition,Identification and Bounds

Abstract. Results are given which provide bounds for controlled direct effects when nounmeasured confounding assumptions required for the identification of these effects do not hold. Previous results concerning bounds for controlled direct effects rely on monotonicity relationships between the treatment, mediator and the outcome themselves; the results presented in this article instead assume that monotonicity relationships hold between the unmeasured confounding variable or variables and the treatment, mediator and outcome. Whereas prior results give bounds that contain the null hypothesis of no direct effect, the results presented here will in many instances yield bounds that do not contain the null hypothesis of no direct effect. For contexts in which a set of variables intercepts all paths between a treatment and an outcome, it is possible to provide a definition for a controlled mediated effect. We discuss the identification of these controlled mediated effects; the bounds for controlled direct effects are applicable also to controlled mediated effects. An example is given to illustrate how the results in the article can be used to draw inferences about direct and mediated effects in the presence of unmeasured confounding variables.     

消费者信心指数与消费需求关系研究——以南京市居民消费需求为例

传统消费理论主要是注重对消费者收入与消费支出的关系研究,而新的西方消费者信心指数理论指出,消费者信心指数对消费支出有重要影响,特别是在当前国内消费需求增长缓慢的情况下,如何提高居民消费信心对刺激居民消费支出的增长有着重要的现实意义。运用计量经济模型,并结合南京市居民消费支出增长与消费者信心指数的数量关系,通过实证研究印证了两者间存在紧密相关性,从而建立南京市居民消费函数的主观因素拓展模型,并进而提出提高居民消费需求的政策建议,即在注重对影响消费的客观因素——收入的研究外,还要注重对影响消费的主观因素——消费者信心指数的研究。     

Simulation study of confidence regions for canonical variate analysis

Canonical variate analysis often involves the construction of confidence regions round points representing group means in a 2-dimensional plot. Traditionally circles have always been constructed, but some authors have recently advocated ellipses as being more appropriate. This paper describes a Monte Carlo study investigating the effect of a range of factors on the inclusion rates of true population means within both types of region for normal data. The traditional circles do not perform too badly within a restricted range, but they are nearly always under-included. The ellipses usually have higher inclusion rates, and so are often closer to the nominal rate, but are sometimes over-included.     

中国消费者信心影响因素实证分析

消费者信心是对消费者整体所表现出来的信心程度及其变动的一种测度。使用离散顺序选择模型对2009年第1季度中国大陆消费者信心指数的原始调查数据进行实证分析,结果显示：消费者对未来经济发展的信心受到其对未来就业、收入、生活和投资四个方面信心的显著影响。     

Optimal simultaneous confidence bands in simple linear regression

A simultaneous confidence band provides useful information on the plausible range of an unknown regression model. For simple linear regression models, the most frequently quoted bands in the statistical literature include the hyperbolic band and the three-segment bands. One interesting question is whether one can construct confidence bands better than the hyperbolic and three-segment bands. The optimality criteria for confidence bands include the average width criterion considered by Gafarian (1964) and Naiman (1984) among others, and the minimum area confidence set (MACS) criterion of Liu and Hayter (2007). In this paper, two families of exact 1−α$1-\alpha$ confidence bands, the inner-hyperbolic bands and the outer-hyperbolic bands, which include the hyperbolic and three-segment bands as special cases, are introduced in simple linear regression. Under the MACS criterion, the best confidence band within each family is found by numerical search and compared with the hyperbolic band, the best three-segment band and with each other. The methodologies are illustrated with a numerical example and the Matlab programs used are available upon request.     

On the Validity of the Bootstrap in Non‐Parametric Functional Regression

Abstract. We consider the functional non‐parametric regression model Y= r( χ )+?, where the response Y is univariate, χ is a functional covariate (i.e. valued in some infinite‐dimensional space), and the error ? satisfies E(? | χ ) = 0. For this model, the pointwise asymptotic normality of a kernel estimator of r (·) has been proved in the literature. To use this result for building pointwise confidence intervals for r (·), the asymptotic variance and bias of need to be estimated. However, the functional covariate setting makes this task very hard. To circumvent the estimation of these quantities, we propose to use a bootstrap procedure to approximate the distribution of . Both a naive and a wild bootstrap procedure are studied, and their asymptotic validity is proved. The obtained consistency results are discussed from a practical point of view via a simulation study. Finally, the wild bootstrap procedure is applied to a food industry quality problem to compute pointwise confidence intervals.     

Random Weighted Bootstrap Method for Recurrent Events with Informative Censoring

Using the data from the AIDS Link to Intravenous Experiences cohort study as an example, an informative censoring model was used to characterize the repeated hospitalization process of a group of patients. Under the informative censoring assumption, the estimators of the baseline rate function and the regression parameters were shown to be related to a latent variable. Hence, it becomes impractical to directly estimate the unknown quantities in the moments of the estimators for the bandwidth selection of a smoothing estimator and the construction of confidence intervals, which are respectively based on the asymptotic mean squared errors and the asymptotic distributions of the estimators. To overcome these difficulties, we develop a random weighted bootstrap procedure to select appropriate bandwidths and to construct approximated confidence intervals. One can see that our method is simple and faster to implement from a practical point of view, and is at least as accurate as other bootstrap methods. In this article, it is shown that the proposed method is useful through the performance of a Monte Carlo simulation. An application of our procedure is also illustrated by a recurrent event sample of intravenous drug users for inpatient cares over time.