A Factor-Adjusted Multiple Testing Procedure With Application to Mutual Fund Selection

In this article, we propose a factor-adjusted multiple testing (FAT) procedure based on factor-adjusted p-values in a linear factor model involving some observable and unobservable factors, for the purpose of selecting skilled funds in empirical finance. The factor-adjusted p-values were obtained after extracting the latent common factors by the principal component method. Under some mild conditions, the false discovery proportion can be consistently estimated even if the idiosyncratic errors are allowed to be weakly correlated across units. Furthermore, by appropriately setting a sequence of threshold values approaching zero, the proposed FAT procedure enjoys model selection consistency. Extensive simulation studies and a real data analysis for selecting skilled funds in the U.S. financial market are presented to illustrate the practical utility of the proposed method. Supplementary materials for this article are available online.     

Empirical evaluation of the implementation of the EMA guideline on missing data in confirmatory clinical trials: Specification of mixed models for longitudinal data in study protocols

In confirmatory clinical trials, the prespecification of the primary analysis model is a universally accepted scientific principle to allow strict control of the type I error. Consequently, both the ICH E9 guideline and the European Medicines Agency (EMA) guideline on missing data in confirmatory clinical trials require that the primary analysis model is defined unambiguously. This requirement applies to mixed models for longitudinal data handling missing data implicitly. To evaluate the compliance with the EMA guideline, we evaluated the model specifications in those clinical study protocols from development phases II and III submitted between 2015 and 2018 to the Ethics Committee at Hannover Medical School under the German Medicinal Products Act, which planned to use a mixed model for longitudinal data in the confirmatory testing strategy. Overall, 39 trials from different types of sponsors and a wide range of therapeutic areas were evaluated. While nearly all protocols specify the fixed and random effects of the analysis model (95%), only 77% give the structure of the covariance matrix used for modeling the repeated measurements. Moreover, the testing method (36%), the estimation method (28%), the computation method (3%), and the fallback strategy (18%) are given by less than half the study protocols. Subgroup analyses indicate that these findings are universal and not specific to clinical trial phases or size of company. Altogether, our results show that guideline compliance is to various degrees poor and consequently, strict type I error rate control at the intended level is not guaranteed.     

Robust inference for estimating equations with nonignorably missing data based on SIR algorithm

Nonresponse is a very common phenomenon in survey sampling. Nonignorable nonresponse – that is, a response mechanism that depends on the values of the variable having nonresponse – is the most difficult type of nonresponse to handle. This article develops a robust estimation approach to estimating equations (EEs) by incorporating the modelling of nonignorably missing data, the generalized method of moments (GMM) method and the imputation of EEs via the observed data rather than the imputed missing values when some responses are subject to nonignorably missingness. Based on a particular semiparametric logistic model for nonignorable missing response, this paper proposes the modified EEs to calculate the conditional expectation under nonignorably missing data. We can apply the GMM to infer the parameters. The advantage of our method is that it replaces the non-parametric kernel-smoothing with a parametric sampling importance resampling (SIR) procedure to avoid nonparametric kernel-smoothing problems with high dimensional covariates. The proposed method is shown to be more robust than some current approaches by the simulations.     

The nested joint clustering via Dirichlet process mixture model

This article focuses on the clustering problem based on Dirichlet process (DP) mixtures. To model both time invariant and temporal patterns, different from other existing clustering methods, the proposed semi-parametric model is flexible in that both the common and unique patterns are taken into account simultaneously. Furthermore, by jointly clustering subjects and the associated variables, the intrinsic complex shared patterns among subjects and among variables are expected to be captured. The number of clusters and cluster assignments are directly inferred with the use of DP. Simulation studies illustrate the effectiveness of the proposed method. An application to wheal size data is discussed with an aim of identifying novel temporal patterns among allergens within subject clusters.     

Zero-inflated sum of Conway-Maxwell-Poissons (ZISCMP) regression

While excess zeros are often thought to cause data over-dispersion (i.e. when the variance exceeds the mean), this implication is not absolute. One should instead consider a flexible class of distributions that can address data dispersion along with excess zeros. This work develops a zero-inflated sum-of-Conway-Maxwell-Poissons (ZISCMP) regression as a flexible analysis tool to model count data that express significant data dispersion and contain excess zeros. This class of models contains several special case zero-inflated regressions, including zero-inflated Poisson (ZIP), zero-inflated negative binomial (ZINB), zero-inflated binomial (ZIB), and the zero-inflated Conway-Maxwell-Poisson (ZICMP). Through simulated and real data examples, we demonstrate class flexibility and usefulness. We further utilize it to analyze shark species data from Australia's Great Barrier Reef to assess the environmental impact of human action on the number of various species of sharks.     

A dimensionality reduction method of continuous dependent variables based supervised Laplacian eigenmaps

Dimensionality reduction is one of the important preprocessing steps in high-dimensional data analysis. In this paper we propose a supervised manifold learning method, it makes use of the information of continuous dependent variables to distinguish intrinsic neighbourhood and extrinsic neighbourhood of data samples, and construct two graphs according to these two kinds of neighbourhoods. Following the idea of Laplacian eigenmaps, we reveal that on the low-dimensional manifold the neighbourhood structure can be preserved or even improved. Our approach has two important characteristics: (i) it uses dependent variables to find an informative low-dimensional projection which is robust to noisy independent variables and (ii) the objective function simultaneously enlarges the distance between dissimilar samples and pushes similar samples close to each other according to the graph constructed with the help of continuous dependent variables. Our experiments demonstrate that the effectiveness of our method is over their traditional rivals.     

Semiparametric regression of clustered current status data

This paper discusses regression analysis of clustered current status data under semiparametric additive hazards models. In particular, we consider the situation when cluster sizes can be informative about correlated failure times from the same cluster. To address the problem, we present estimating equation-based estimation procedures and establish asymptotic properties of the resulting estimates. Finite sample performance of the proposed method is assessed through an extensive simulation study, which indicates the procedure works well. The method is applied to a motivating data set from a lung tumorigenicity study.     

Assessing the market values of soccer players – a robust analysis of data from German 1. and 2. Bundesliga

The paper examines to what extent a player's market value depends on his skills. Therefore, a data set covering 28 performance measures and the market values of about 493 players from 1. and 2. German Bundesliga is analysed. Applying robust analysis techniques, we are able to robustly estimate market values of soccer players. The results show (1) that there are significantly underrated and overrated players and (2) that a player's affiliation to a certain team may contribute to his market value. We conclude that a club's reputation affects the market values of its players and that star players are in tendency overrated.     

Quantile regression for large-scale data via sparse exponential transform method

In recent decades, quantile regression has received much more attention from academics and practitioners. However, most of existing computational algorithms are only effective for small or moderate size problems. They cannot solve quantile regression with large-scale data reliably and efficiently. To this end, we propose a new algorithm to implement quantile regression on large-scale data using the sparse exponential transform (SET) method. This algorithm mainly constructs a well-conditioned basis and a sampling matrix to reduce the number of observations. It then solves a quantile regression problem on this reduced matrix and obtains an approximate solution. Through simulation studies and empirical analysis of a 5% sample of the US 2000 Census data, we demonstrate efficiency of the SET-based algorithm. Numerical results indicate that our new algorithm is effective in terms of computation time and performs well for large-scale quantile regression.     

Linear scalar-on-surface random effects regression models

Many research fields increasingly involve analyzing data of a complex structure. Models investigating the dependence of a response on a predictor have moved beyond the ordinary scalar-on-vector regression. We propose a regression model for a scalar response and a surface (or a bivariate function) predictor. The predictor has a random component and the regression model falls in the framework of linear random effects models. We estimate the model parameters via maximizing the log-likelihood with the ECME (Expectation/Conditional Maximization Either) algorithm. We use the approach to analyze a data set where the response is the neuroticism score and the predictor is the resting-state brain function image. In the simulations we tried, the approach has better performance than two other approaches, a functional principal component regression approach and a smooth scalar-on-image regression approach.