Break point detection for functional covariance

Many neuroscience experiments record sequential trajectories where each trajectory consists of oscillations and fluctuations around zero. Such trajectories can be viewed as zero-mean functional data. When there are structural breaks in higher-order moments, it is not always easy to spot these by mere visual inspection. Motivated by this challenging problem in brain signal analysis, we propose a detection and testing procedure to find the change point in functional covariance. The detection procedure is based on the cumulative sum statistics (CUSUM). The fully functional testing procedure relies on a null distribution which depends on infinitely many unknown parameters, though in practice only a finite number of these parameters can be included for the hypothesis test of the existence of change point. This paper provides some theoretical insights on the influence of the number of parameters. Meanwhile, the asymptotic properties of the estimated change point are developed. The effectiveness of the proposed method is numerically validated in simulation studies and an application to investigate changes in rat brain signals following an experimentally-induced stroke.     

Improved inference for MCP-Mod approach using time-to-event endpoints with small sample sizes

The Multiple Comparison Procedures with Modeling Techniques (MCP-Mod) framework has been recently approved by the U.S. Food, Administration, and European Medicines Agency as fit-for-purpose for phase II studies. Nonetheless, this approach relies on the asymptotic properties of Maximum Likelihood (ML) estimators, which might not be reasonable for small sample sizes. In this paper, we derived improved ML estimators and correction for their covariance matrices in the censored Weibull regression model based on the corrective and preventive approaches. We performed two simulation studies to evaluate ML and improved ML estimators with their covariance matrices in (i) a regression framework (ii) the Multiple Comparison Procedures with Modeling Techniques framework. We have shown that improved ML estimators are less biased than ML estimators yielding Wald-type statistics that controls type I error without loss of power in both frameworks. Therefore, we recommend the use of improved ML estimators in the MCP-Mod approach to control type I error at nominal value for sample sizes ranging from 5 to 25 subjects per dose.     

Objective Bayes Covariate‐Adjusted Sparse Graphical Model Selection

We present an objective Bayes method for covariance selection in Gaussian multivariate regression models having a sparse regression and covariance structure, the latter being Markov with respect to a directed acyclic graph (DAG). Our procedure can be easily complemented with a variable selection step, so that variable and graphical model selection can be performed jointly. In this way, we offer a solution to a problem of growing importance especially in the area of genetical genomics (eQTL analysis). The input of our method is a single default prior, essentially involving no subjective elicitation, while its output is a closed form marginal likelihood for every covariate‐adjusted DAG model, which is constant over each class of Markov equivalent DAGs; our procedure thus naturally encompasses covariate‐adjusted decomposable graphical models. In realistic experimental studies, our method is highly competitive, especially when the number of responses is large relative to the sample size.     

Mixed linear regression with equi-cross-correlated errors

Received: August 12, 1999; revised version: April 3, 2000     

A permutation procedure for testing the equality of pattern hypotheses across groups involving correlation or covariance matrices

This paper describes a permutation procedure to test for the equality of selected elements of a covariance or correlation matrix across groups. It involves either centring or standardising each variable within each group before randomly permuting observations between groups. Since the assumption of exchangeability of observations between groups does not strictly hold following such transformations, Monte Carlo simulations were used to compare expected and empirical rejection levels as a function of group size, the number of groups and distribution type (Normal, mixtures of Normals and Gamma with various values of the shape parameter). The Monte Carlo study showed that the estimated probability levels are close to those that would be obtained with an exact test except at very small sample sizes (5 or 10 observations per group). The test appears robust against non-normal data, different numbers of groups or variables per group and unequal sample sizes per group. Power was increased with increasing sample size, effect size and the number of elements in the matrix and power was decreased with increasingly unequal numbers of observations per group.     

Non-parametric Curve Estimation by Wavelet Thresholding with Locally Stationary Errors

An important aspect in the modelling of biological phenomena in living organisms, whether the measurements are of blood pressure, enzyme levels, biomechanical movements or heartbeats, etc., is time variation in the data. Thus, the recovery of a 'smooth' regression or trend function from noisy time-varying sampled data becomes a problem of particular interest. Here we use non-linear wavelet thresholding to estimate a regression or a trend function in the presence of additive noise which, in contrast to most existing models, does not need to be stationary. (Here, non-stationarity means that the spectral behaviour of the noise is allowed to change slowly over time). We develop a procedure to adapt existing threshold rules to such situations, e.g. that of a time-varying variance in the errors. Moreover, in the model of curve estimation for functions belonging to a Besov class with locally stationary errors, we derive a near-optimal rate for the -risk between the unknown function and our soft or hard threshold estimator, which holds in the general case of an error distribution with bounded cumulants. In the case of Gaussian errors, a lower bound on the asymptotic minimax rate in the wavelet coefficient domain is also obtained. Also it is argued that a stronger adaptivity result is possible by the use of a particular location and level dependent threshold obtained by minimizing Stein's unbiased estimate of the risk. In this respect, our work generalizes previous results, which cover the situation of correlated, but stationary errors. A natural application of our approach is the estimation of the trend function of non-stationary time series under the model of local stationarity. The method is illustrated on both an interesting simulated example and a biostatistical data-set, measurements of sheep luteinizing hormone, which exhibits a clear non-stationarity in its variance.     

Outliers detection with the minimum covariance determinant estimator in practice

Robust statistics have slowly become familiar to all practitioners. Books entirely devoted to the subject (e.g. [R.A. Maronna, R.D. Martin, V.J. Yohai, Robust Statistics: Theory and Methods. John Wiley &; Sons, New York, NY, USA, 2006; P.J. Rousseeuw, A.M. Leroy, Robust Regression and Outlier Detection, John Wiley &; Sons, New York, NY, USA, 1987], …) are without any doubt responsible for the increased practice of robust statistics in all fields of applications. Even classical books often have at least one chapter (or parts of chapters) which develops robust methodology. The improvement of computing power has also contributed to the development of a wider and wider range of available robust procedures. However, this success story is now menacing to get backwards: non-specialists interested in the application of robust methodology are faced with a large set of (assumed equivalent) methods and with over-sophistication of some of them. Which method should one use? How should the (numerous) parameters be optimally tuned? These questions are not so easy to answer for non-specialists! One could then argue that default procedures are available in most statistical software (Splus, R, SAS, Matlab, …). However, using as illustration the detection of outliers in multivariate data, it is shown that, on one hand, it is not obvious that one would feel confident with the output of default procedures, and that, on the other hand, trying to understand thoroughly the tuning parameters involved in the procedures might require some extensive research. This is not conceivable when trying to compete with the classical methodology which (while clearly unreliable) is so straightforward. The aim of the paper is to help the practitioners willing to detect in a reliable way outliers in a multivariate data set. The chosen methodology is the Minimum Covariance Determinant estimator being widely available and intuitively appealing.     

Finding an unknown number of multivariate outliers

Summary.  We use the forward search to provide robust Mahalanobis distances to detect the presence of outliers in a sample of multivariate normal data. Theoretical results on order statistics and on estimation in truncated samples provide the distribution of our test statistic. We also introduce several new robust distances with associated distributional results. Comparisons of our procedure with tests using other robust Mahalanobis distances show the good size and high power of our procedure. We also provide a unification of results on correction factors for estimation from truncated samples.     

Modified regression estimators using robust regression methods and covariance matrices in stratified random sampling

Abstract

This article proposes new regression-type estimators by considering Tukey-M, Hampel M, Huber MM, LTS, LMS and LAD robust methods and MCD and MVE robust covariance matrices in stratified sampling. Theoretically, we obtain the mean square error (MSE) for these estimators. We compare the efficiencies based on MSE equations, between the proposed estimators and the traditional combined and separate regression estimators. As a result of these comparisons, we observed that our proposed estimators give more efficient results than traditional approaches. And, these theoretical results are supported with the aid of numerical examples and simulation based on data sets that include outliers.