Water Adherence Factors for Human Skin

On incidental dermal exposure to chemicals in water, a key exposure factor is the amount of water adhering to skin. Although soil adherence factors have been developed for risk assessment, measurements of water adherence on human skin have not been described. In the Environmental Protection Agency's (EPA's) dermal risk assessment guidance, dermal dose from environmental exposures is based upon the flux rate across the skin, which assumes that an unlimited amount of chemical is available for absorption. This assumption is applicable to certain exposure scenarios such as swimming and bathing. However, exposures to contaminated water frequently involve scenarios where the available chemical is limited by the amount of water adhering to the skin, for example, during accidental splashes. We conducted studies in human volunteers to investigate water adherence per unit area of skin after brief contact with water. In two sets of experiments, either water was applied with a micropipette to 10‐cm² areas of the lower leg, foot, and hand, or the foot and hand were briefly immersed in water. In males, using a micropipette, water adherence ranged from 1.93 (foot) to 7.13 μL/cm² (lower leg). In females, it ranged from 1.10 (lower leg) to 4.83 μL/cm² (hand). Hand and foot immersion resulted in relatively higher values of 6.89 and 5.17 μL/cm², respectively, in males, and 5.40 and 6.39 μL/cm² in females. Water adherence was affected by amount of body hair and type of exposure. Water adherence factors can be used to calculate the applied dose per unit area for exposures involving intermittent water contact.     

Employee Assistance Program Staffing

No abstract available for this article.     

On Second-Order A-, D- and E-Minimax Designs for Estimating Slopes in Extrapolation and Restricted Interpolation Regions

Summary

The concepts of D-, A- and E-minimax optimality criteria of designs for estimating the slopes of a response surface are considered for situations where the region of interest may not be identical to the experimental region. Optimal second-order designs are derived for the situation where the experimental region and the region of interest are both hyperspherical with a common centre. The dependence of the optimal design on the relative sizes of the regions is investigated. Further, the perfomance of designs optimal for one region in estimating slopes in other regions is also examined.     

Sensitivity studies of air scattered neutron dose from particle accelerators

Sensitivity analysis of air scattered neutron dose at several distances from a particle accelerator with respect to shield thickness and neutron yield distributions has been carried out. We illustrate the successful use of Response Surface Methodology in studying the behaviour of the sensitivity coefficients for main effects and interaction terms. A comparison of the full six factor design and the orthogonal Central Composite Design has been made. The overhead shield is found to be the most sensitive parameter followed by the high energy part of the neutron energy distribution.     

Response-Response Relationships in Organizational Behavior Management

Abstract

The issue of behavioral covariation has been a topic of interest to behavior analysts for many years. Many writers have used the term response generalization interchangeably with behavioral covariation. In this paper, we argue from the extant literature that the term “response generalization” should be used to describe only very specific occasions of behavioral covariation. In fact, we argue, response generalization is merely one of at least six types of behavioral covariation observed in organizational behavior management studies. After describing response generalization, the remaining five types of response-response relations we describe are: (1) physiological relations, (2) when target behaviors occasion related behaviors, (3) when target behaviors reinforce related behaviors, (4) when target and related behaviors are maintained by the same reinforcing stimulus, and (5) covariation through participation in verbal relations. We conclude by discussing the potential for additional research on this topic in the area of verbal relations.     

Linking Elderly to Holistic Care Services through Integrated Communication Technology: The Personal Emergency Link Service Rendered by the Senior Citizen Home Safety Association in Hong Kong

Through a Personal Emergency Link system, the Senior Citizen Home Safety Association has rendered 24-hour care to more than 111,000 service users in Hong Kong who are mostly vulnerable seniors and chronic invalids living alone or living with their elderly spouses/caregivers only. This article will describe how the Personal Emergency Link system is used to link seniors living in the community. Measures taken to prevent failure of the system will be described. With the use of different technology applications, many human touches and warm caregiving are rendered to the elderly and needy.     

川东T构造须家河组储层地震响应及形成机制

对川东T构造须家河组含气储层的地球物理响应特征进行了分析，采用地质与地球物理互馈结合的手段，通过合成记录正演、储层置换的方法进行了其地质形成机制研究。结果表明：T构造须家河组含气储层主要表现为低频率、弱振幅（近空白）反射，其形成机制主要有两方面的因素，一是含气层速度的降低导致振幅减弱，在薄层叠加效应的作用下，含气层下部出现弱振幅；二是含气层对高频的吸收作用，低频率导致砂泥岩互层无法分辨，表现为弱振幅。最终形成的低频率、弱振幅特征是这两种因素的综合响应，该特征在Ｔ构造高部位可以作为识别含气储层的标志。     

Robust williams trent test

To investigate the biological activities of a new compound or drug, experimenters usually compare a series of increasing doses to a control. Among other objectives, one may try to investigate any possible dose-response trend and to determine the minimum effective dose among all the experimental doses. Williams (1971, 1972) proposed a procedure to test the dose-response trend and also to identify the minimum effective dose based on the normally distributed data. In this paper, we propose a similar test procedure based on the robust estimate'of the average response to perform similar analysis. The proposed method is more resistant to the outliers and more powerful than the Williams procedure when the data distribution deviates from normality. We illustrate the use of this procedure with data arising from a recent study.     

Construction of New Three-Level Response Surface Designs

Response surface methodology is widely used for developing, improving, and optimizing processes in various fields. In this article, we present a method for constructing three-level designs in order to explore and optimize response surfaces combining orthogonal arrays and covering arrays in a particular manner. The produced designs achieve the properties of rotatability, predictive performance and efficiency for the estimation of a second-order model.