狂野爱情的毁灭——从电视剧《金锁记》谈改编艺术

电视剧<金锁记>在遵循原作内在精神的基础上,从不同的角度糅合了现代人的审美特质,与现代人产生共鸣.改编后的<金锁记>所带来的艺术效果是强烈的,为改编艺术提供了一种参考和借鉴.     

移动互联网时代教育舆情风险防范与危机应对探析

移动互联网时代,教育舆情的呈现日益显在化,教育舆情的类型日渐多元化,教育舆情的演化日趋复杂化;与此同时,教育舆情处置面临着教育舆情风险不确定性增大、教育舆情冲突破坏性加重、教育舆情危机化解难度升高等诸多新挑战。应该针对当前移动互联网时代教育舆情生成与演化各阶段的特点,做好教育舆情态势的识别与研判,抓好教育舆情风险的预警与防范。同时,明确教育舆情危机应对的责任主体及其处置权限;及时发声,回应社会关切,掌控舆情走向;解决问题,化解矛盾,平息舆情危机;妥善做好相关善后事宜,防止舆情反复及次生舆情事件的发生。     

语言应急和应急语言

基于2020年我国发生的新冠肺炎疫情防控过程中语言服务的相关事实来观察语言应急和应急语言,讨论其与社会语言生活相关的一些问题。研究认为语言应急和应急语言具有不同的领域分野,语言应急侧重从社会行为视角进行观察,可以分为自发应急和自觉应急,其内部各有表现与特征;应急语言侧重从语言符号系统视角进行观察,在需求、规划、使用三个方面各有不同的特征维度与表现。文章进一步基于语言应急和提高应急速率、应急语言和提高应急质量目的,针对语言应急体制机制建设提出了三个方面的申论和建议,希望能从语言应急和应急语言的角度对国家治理体系的建设和治理能力的提高有所贡献。     

"首唱"与"唱和"--再论法治的"共识效应"

要建成中国特色的社会主义法治国家,首先应从理论与实践的层面上解决好社会性的号召与个体的道德响应之间的关系,笔者称其为形成法律人的"首唱"与非法律人的"唱和"的法治的共识效应.为此,本文通过对"共识效应"进行理论论证与实证分析后,试图从精英文化与大众文化对立统一的视角,对全球化背景下的当代中国法治建设,提出具有中庸思想特色的若干己见.     

工业企业生产能力的确定及实现模式分析

在现代市场经济环境下,工业企业竞争优势的形成与其快速反应客户需求的能力密切相关,而企业的这一能力又与其生产能力水平存在着内在的联系;考察各种影响企业合理生产能力水平的因素,可以看到,采取虚拟经营方式,是一种全新的企业生产能力实现模式。     

基于驾驶员反应行为的诱导博弈分析

运用博弈论的概念与方法，剖析驾驶员对诱导信息的反应行为，研究其他驾驶员的决策对某一特定决策过程的外在影响，并就科学的诱导策略进行探讨．     

试论网络会计的形成及其发展对策

由于网络技术的产生及其在会计领域中的广泛应用,网络会计应运而生,成为会计发展的新领域。网络会计在产生及逐渐发展的过程中,面临着一些问题,需要制定相应对策,使网络会计逐步完善。     

A bias analysis of Weibull models under heaped data

Retrospectively collected duration data are often reported incorrectly. An important type of such an error is heaping—respondents tend to round-off or round-up the data according to some rule of thumb. For two special cases of the Weibull model we study the behaviour of the ‘naive estimators’, which simply ignore the measurement error due to heaping, and derive closed expressions for the asymptotic bias. These results give a formal justification of empirical evidence and simulation-based findings reported in the literature. Additionally, situations where a remarkable bias has to be expected can be identified, and an exact bias correction can be performed.     

Models of Neurotoxicity: Extrapolation of Benchmark Doses in Vitro

In risk assessment, no observed exposure level (NOAEL) and benchmark dose (BMD) are usually derived either from epidemiological studies in humans or from animal experiments. In many in vitro studies, concentration-effect/response curves have been analyzed using different mathematical models finalized to the identification of EC50. In the present article, we propose a model to fit dose-response curves in vitro. The BMD approach has been used to compare the cell viability (MIT assay) of different rat (C6 and PC12, glial and neuronal, respectively) and human cell lines (D384 and SK-N-MC, glial and neuronal, respectively) after 24-hour exposure to the following neurotoxic substances: manganese chloride (MnCl2), methyl-mercury (Me-Hg), and the enantiomers of styrene oxide (SO). For all rat and human cell lines, the potency of the examined compounds was: MnCl2 < S-SO < R-SO < Me-Hg. A preliminary comparison with in vivo toxicity data for these substances gave rise to consistent results. Whereas a reasonable agreement between in vitro and in vivo data has been found for Mn and styrene oxide, a wide scatter of LOAEL has been reported for Me-Hg and these appear to be either much higher or lower than the BMD for the MIT assay we observed in vitro.     

Addressing Nonlinearity in the Exposure-Response Relationship for a Genotoxic Carcinogen: Cancer Potency Estimates for Ethylene Oxide

Ethylene oxide (EO) has been identified as a carcinogen in laboratory animals. Although the precise mechanism of action is not known, tumors in animals exposed to EO are presumed to result from its genotoxicity. The overall weight of evidence for carcinogenicity from a large body of epidemiological data in the published literature remains limited. There is some evidence for an association between EO exposure and lympho/hematopoietic cancer mortality. Of these cancers, the evidence provided by two large cohorts with the longest follow-up is most consistent for leukemia. Together with what is known about human leukemia and EO at the molecular level, there is a body of evidence that supports a plausible mode of action for EO as a potential leukemogen. Based on a consideration of the mode of action, the events leading from EO exposure to the development of leukemia (and therefore risk) are expected to be proportional to the square of the dose. In support of this hypothesis, a quadratic dose-response model provided the best overall fit to the epidemiology data in the range of observation. Cancer dose-response assessments based on human and animal data are presented using three different assumptions for extrapolating to low doses: (1) risk is linearly proportionate to dose; (2) there is no appreciable risk at low doses (margin-of-exposure or reference dose approach); and (3) risk below the point of departure continues to be proportionate to the square of the dose. The weight of evidence for EO supports the use of a nonlinear assessment. Therefore, exposures to concentrations below 37 microg/m3 are not likely to pose an appreciable risk of leukemia in human populations. However, if quantitative estimates of risk at low doses are desired and the mode of action for EO is considered, these risks are best quantified using the quadratic estimates of cancer potency, which are approximately 3.2- to 32-fold lower, using alternative points of departure, than the linear estimates of cancer potency for EO. An approach is described for linking the selection of an appropriate point of departure to the confidence in the proposed mode of action. Despite high confidence in the proposed mode of action, a small linear component for the dose-response relationship at low concentrations cannot be ruled out conclusively. Accordingly, a unit risk value of 4.5 x 10(-8) (microg/m3)(-1) was derived for EO, with a range of unit risk values of 1.4 x 10(-8) to 1.4 x 10(-7) (microg/m3)(-1) reflecting the uncertainty associated with a theoretical linear term at low concentrations.