Estimation under modified Weibull distribution based on right censored generalized order statistics

In this paper, the maximum likelihood (ML) and Bayes, by using Markov chain Monte Carlo (MCMC), methods are considered to estimate the parameters of three-parameter modified Weibull distribution (MWD(β, τ, λ)) based on a right censored sample of generalized order statistics (gos). Simulation experiments are conducted to demonstrate the efficiency of the proposed methods. Some comparisons are carried out between the ML and Bayes methods by computing the mean squared errors (MSEs), Akaike's information criteria (AIC) and Bayesian information criteria (BIC) of the estimates to illustrate the paper. Three real data sets from Weibull(α, β) distribution are introduced and analyzed using the MWD(β, τ, λ) and also using the Weibull(α, β) distribution. A comparison is carried out between the mentioned models based on the corresponding Kolmogorov–Smirnov (K–S) test statistic, {AIC and BIC} to emphasize that the MWD(β, τ, λ) fits the data better than the other distribution. All parameters are estimated based on type-II censored sample, censored upper record values and progressively type-II censored sample which are generated from the real data sets.     

Robust location estimation with missing data

In a missing data setting, we have a sample in which a vector of explanatory variables ${\bf x}_i$ is observed for every subject i, while scalar responses $y_i$ are missing by happenstance on some individuals. In this work we propose robust estimators of the distribution of the responses assuming missing at random (MAR) data, under a semiparametric regression model. Our approach allows the consistent estimation of any weakly continuous functional of the response's distribution. In particular, strongly consistent estimators of any continuous location functional, such as the median, L‐functionals and M‐functionals, are proposed. A robust fit for the regression model combined with the robust properties of the location functional gives rise to a robust recipe for estimating the location parameter. Robustness is quantified through the breakdown point of the proposed procedure. The asymptotic distribution of the location estimators is also derived. The proofs of the theorems are presented in Supplementary Material available online. The Canadian Journal of Statistics 41: 111–132; 2013 © 2012 Statistical Society of Canada     

Estimation with right‐censored observations under a semi‐Markov model

The semi‐Markov process often provides a better framework than the classical Markov process for the analysis of events with multiple states. The purpose of this paper is twofold. First, we show that in the presence of right censoring, when the right end‐point of the support of the censoring time is strictly less than the right end‐point of the support of the semi‐Markov kernel, the transition probability of the semi‐Markov process is nonidentifiable, and the estimators proposed in the literature are inconsistent in general. We derive the set of all attainable values for the transition probability based on the censored data, and we propose a nonparametric inference procedure for the transition probability using this set. Second, the conventional approach to constructing confidence bands is not applicable for the semi‐Markov kernel and the sojourn time distribution. We propose new perturbation resampling methods to construct these confidence bands. Different weights and transformations are explored in the construction. We use simulation to examine our proposals and illustrate them with hospitalization data from a recent cancer survivor study. The Canadian Journal of Statistics 41: 237–256; 2013 © 2013 Statistical Society of Canada     

A comparison of test statistics for the recovery of rapid growth‐based enumeration tests

This paper considers five test statistics for comparing the recovery of a rapid growth‐based enumeration test with respect to the compendial microbiological method using a specific nonserial dilution experiment. The finite sample distributions of these test statistics are unknown, because they are functions of correlated count data. A simulation study is conducted to investigate the type I and type II error rates. For a balanced experimental design, the likelihood ratio test and the main effects analysis of variance (ANOVA) test for microbiological methods demonstrated nominal values for the type I error rate and provided the highest power compared with a test on weighted averages and two other ANOVA tests. The likelihood ratio test is preferred because it can also be used for unbalanced designs. It is demonstrated that an increase in power can only be achieved by an increase in the spiked number of organisms used in the experiment. The power is surprisingly not affected by the number of dilutions or the number of test samples. A real case study is provided to illustrate the theory. Copyright © 2013 John Wiley & Sons, Ltd.     

On the recoding of continuous and bounded indexes to a binomial form: an application to quality-of-life scores

The statistical analysis of patient-reported outcomes (PROs) as endpoints has shown to be of great practical relevance. The resulting scores or indexes from the questionnaires used to measure PROs could be treated as continuous or ordinal. The goal of this study is to propose and evaluate a recoding process of the scores, so that they can be treated as binomial outcomes and, therefore, analyzed using logistic regression with random effects. The general methodology of recoding is based on the observable values of the scores. In order to obtain an optimal recoding, the evaluation of the recoding method is tested for different values of the parameters of the binomial distribution and different probability distributions of the random effects. We illustrate, evaluate and validate the proposed method of recoding with the Short Form-36 (SF-36) Survey and real data. The optimal recoding approach is very useful and flexible. Moreover, it has a natural interpretation, not only for ordinal scores, but also for questionnaires with many dimensions and different profiles, where a common method of analysis is desired, such as the SF-36.     

A time-varying measurement error model for age of onset of a psychiatric diagnosis: applied to first depressive episode diagnosed by the Composite International Diagnostic Interview (CIDI)

A substantial degree of uncertainty exists surrounding the reconstruction of events based on memory recall. This form of measurement error affects the performance of structured interviews such as the Composite International Diagnostic Interview (CIDI), an important tool to assess mental health in the community. Measurement error probably explains the discrepancy in estimates between longitudinal studies with repeated assessments (the gold-standard), yielding approximately constant rates of depression, versus cross-sectional studies which often find increasing rates closer in time to the interview. Repeated assessments of current status (or recent history) are more reliable than reconstruction of a person's psychiatric history based on a single interview. In this paper, we demonstrate a method of estimating a time-varying measurement error distribution in the age of onset of an initial depressive episode, as diagnosed by the CIDI, based on an assumption regarding age-specific incidence rates. High-dimensional non-parametric estimation is achieved by the EM-algorithm with smoothing. The method is applied to data from a Norwegian mental health survey in 2000. The measurement error distribution changes dramatically from 1980 to 2000, with increasing variance and greater bias further away in time from the interview. Some influence of the measurement error on already published results is found.     

Modelling small and medium enterprise loan defaults as rare events: the generalized extreme value regression model

A pivotal characteristic of credit defaults that is ignored by most credit scoring models is the rarity of the event. The most widely used model to estimate the probability of default is the logistic regression model. Since the dependent variable represents a rare event, the logistic regression model shows relevant drawbacks, for example, underestimation of the default probability, which could be very risky for banks. In order to overcome these drawbacks, we propose the generalized extreme value regression model. In particular, in a generalized linear model (GLM) with the binary-dependent variable we suggest the quantile function of the GEV distribution as link function, so our attention is focused on the tail of the response curve for values close to one. The estimation procedure used is the maximum-likelihood method. This model accommodates skewness and it presents a generalisation of GLMs with complementary log–log link function. We analyse its performance by simulation studies. Finally, we apply the proposed model to empirical data on Italian small and medium enterprises.     

A note on statistical method for genotype calling of high-throughput single-nucleotide polymorphism arrays

We study the genotype calling algorithms for the high-throughput single-nucleotide polymorphism (SNP) arrays. Building upon the novel SNP-robust multi-chip average preprocessing approach and the state-of-the-art corrected robust linear model with Mahalanobis distance (CRLMM) approach for genotype calling, we propose a simple modification to better model and combine the information across multiple SNPs with empirical Bayes modeling, which could often significantly improve the genotype calling of CRLMM. Through applications to the HapMap Trio data set and a non-HapMap test set of high quality SNP chips, we illustrate the competitive performance of the proposed method.     

Block and Basu bivariate lifetime distribution in the presence of cure fraction

This paper presents estimates for the parameters included in the Block and Basu bivariate lifetime distributions in the presence of covariates and cure fraction, applied to analyze survival data when some individuals may never experience the event of interest and two lifetimes are associated with each unit. A Bayesian procedure is used to get point and confidence intervals for the unknown parameters. Posterior summaries of interest are obtained using standard Markov Chain Monte Carlo methods in rjags package for R software. An illustration of the proposed methodology is given for a Diabetic Retinopathy Study data set.     

On a bounded bimodal two-sided distribution fitted to the Old-Faithful geyser data

In this paper, we shall develop a novel family of bimodal univariate distributions (also allowing for unimodal shapes) and demonstrate its use utilizing the well-known and almost classical data set involving durations and waiting times of eruptions of the Old-Faithful geyser in Yellowstone park. Specifically, we shall analyze the Old-Faithful data set with 272 data points provided in Dekking et al. [3]. In the process, we develop a bivariate distribution using a copula technique and compare its fit to a mixture of bivariate normal distributions also fitted to the same bivariate data set. We believe the fit-analysis and comparison is primarily illustrative from an educational perspective for distribution theory modelers, since in the process a variety of statistical techniques are demonstrated. We do not claim one model as preferred over the other.