Estimation of Benchmark Dose of Lifetime Cadmium Intake for Adverse Renal Effects Using Hybrid Approach in Inhabitants of an Environmentally Exposed River Basin in Japan

The aim of this study is to estimate the reference level of lifetime cadmium intake (LCd) as the benchmark doses (BMDs) and their 95% lower confidence limits (BMDLs) for various renal effects by applying a hybrid approach. The participants comprised 3,013 (1,362 men and 1,651 women) and 278 (129 men and 149 women) inhabitants of the Cd‐polluted and nonpolluted areas, respectively, in the environmentally exposed Kakehashi River basin. Glucose, protein, aminonitrogen, metallothionein, and β₂‐microglobulin in urine were measured as indicators of renal dysfunction. The BMD and BMDL that corresponded to an additional risk of 5% were calculated with background risk at zero exposure set at 5%. The obtained BMDLs of LCd were 3.7 g (glucose), 3.2 g (protein), 3.7 g (aminonitrogen), 1.7 g (metallothionein), and 1.8 g (β₂‐microglobulin) in men and 2.9 g (glucose), 2.5 g (protein), 2.0 g (aminonitrogen), 1.6 g (metallothionein), and 1.3 g (β₂‐microglobulin) in women. The lowest BMDL was 1.7 g (metallothionein) and 1.3 g (β₂‐microglobulin) in men and women, respectively. The lowest BMDL of LCd (1.3 g) was somewhat lower than the representative threshold LCd (2.0 g) calculated in the previous studies. The obtained BMDLs may contribute to further discussion on the health risk assessment of cadmium exposure.     

Do Interactions Between Environmental Chemicals and the Human Microbiome Need to Be Considered in Risk Assessments?

One of the most dynamic and fruitful areas of current health‐related research concerns the various roles of the human microbiome in disease. Evidence is accumulating that interactions between substances in the environment and the microbiome can affect risks of disease, in both beneficial and adverse ways. Although most of the research has concerned the roles of diet and certain pharmaceutical agents, there is increasing interest in the possible roles of environmental chemicals. Chemical risk assessment has, to date, not included consideration of the influence of the microbiome. We suggest that failure to consider the possible roles of the microbiome could lead to significant error in risk assessment results. Our purpose in this commentary is to summarize some of the evidence supporting our hypothesis and to urge the risk assessment community to begin considering and influencing how results from microbiome‐related research could be incorporated into chemical risk assessments. An additional emphasis in our commentary concerns the distinct possibility that research on chemical–microbiome interactions will also reduce some of the significant uncertainties that accompany current risk assessments. Of particular interest is evidence suggesting that the microbiome has an influence on variability in disease risk across populations and (of particular interest to chemical risk) in animal and human responses to chemical exposure. The possible explanatory power of the microbiome regarding sources of variability could reduce what might be the most significant source of uncertainty in chemical risk assessment.     

WTO下构建环境保护与自由贸易法律制度之分析

WTO机制有利于实现全球贸易自由化,但其有关的环境规则又对自由贸易产生直接或间接影响,使我国的自由贸易既面临挑战也面临机遇。我国加入WTO后的环境保护和自由贸易法律制度应适应WTO的环境规则,提高国民的环保意识;完善环境贸易法律,积极推动我国绿色贸易的发展;积极利用WTO规则及其争端解决机制以及强化贸易与环境执法,才能使我国的环境保护与自由贸易法律制度与国际市场全面接轨。     

论公民环境教育的目标共生

公民环境教育的目标问题是有关环境教育研究领域的一个重要方向。全面而系统的公民环境教育目标谱系应该包含知识、技能、意识、伦理、行为、评价与建议以及意愿等七个维度。而七个维度目标之间的互利共生是公民环境教育层次提升、效果提高的必由之路。     

环境管制、知识产权保护与区域创新能力——基于我国省际面板数据的实证研究

文章基于政府主导视角,利用2006—2015年我国30个省级面板数据,构建多元回归模型,分析变量之间的关系.其结果显示,环境管制、知识产权保护与区域创新能力之间呈非线性关系,环境管制与知识产权保护同时实施对区域创新能力有显著的促进作用,且具有区域异质性.从企业生存角度出发,提出门槛效应假说,采用Hansen面板门槛回归模型进行检验.结果表明,在环境管制与知识产权保护共同发挥作用时,环境管制必须控制在合理的范围内.最后采用门槛效应回归方法找到了环境管制与知识产权保护对区域创新能力影响的门槛值,并提出相应的政策建议.     

Attenuating Initial Beliefs: Increasing the Acceptance of Anthropogenic Climate Change Information by Reflecting on Values

Anthropogenic climate change information tends to be interpreted against the backdrop of initial environmental beliefs, which can lead to some people being resistant toward the information. In this article (N = 88), we examined whether self‐affirmation via reflection on personally important values could attenuate the impact of initial beliefs on the acceptance of anthropogenic climate change evidence. Our findings showed that initial beliefs about the human impact on ecological stability influenced the acceptance of information only among nonaffirmed participants. Self‐affirmed participants who were initially resistant toward the information showed stronger beliefs in the existence of climate change risks and greater acknowledgment that individual efficacy has a role to play in reducing climate change risks than did their nonaffirmed counterparts.     

中国环境立法的困境与出路

在环境法律实践的过程中,通过与污染受害者沟通和交流,发现许多问题都是根源于环境立法存在的问题。也就是,环境立法中的单向的立法理念,只注重至上而下的国家力量,这会导致法律与最初目的的偏离,从保护环境利益走向保护部门利益。因此,要寻求新的出路——发展双向融合的立法理念,即注重至上而下的政府主导与至下而上的公众参与有机结合,通过公众有效参与环境立法,发现环境法律实践中的问题,及时反馈到立法领域。从而在有效的互动中完善环境法治。     

当代环境文化建设的理论变革及其发展趋势

人类的环境文化表征着人与自然之间相互关系变迁的整个过程。面对近现代以来被扭曲和异化的环境文化,当代环境文化正在进行理论变革。必须全面推进可持续发展战略,转变工业生产方式、经济增长模式和人们生活方式,从而建立起人与自然协同进化、促进环境公平和实现生态现代化的当代新型环境文化。     

Testing hypotheses for the growth curve model when the data are incomplete

Kleinbaum (1973) developed a generalized growth curve model for analyzing incomplete longitudinal data. In this paper the small sample properties of several related test statistics are investigated via Monte Carlo techniques. The covariance matrix is estimated by each of three non-iterative methods. The null and non-null distributions of these test statistics are examined.     

Financial policy innovation for social change: a case study of China's green credit policy

Financial policy impacts on a range of social issues such as poverty alleviation, education, pollution control, etc. Making good use of financial policy and applying innovation to existing financial systems can generate positive outcomes for society. This article is to discuss the case of green credit policy in China. This policy was jointly announced in 2007 by financial and environmental regulators. According to this policy, banks were encouraged to give more loans to environmental friendly companies than to others. Such policy has made great progress, and it became a more formal document entitled ‘Green Credit Guideline’ in 2012. This guideline included a comprehensive definition on green credit and specified several requirements at practical levels. Despite the great success, challenges of implementing such policy still remain. First, information about corporate environmental performance is insufficient; second, market incentives for green credit policy are not high enough; third, most banking staff lack knowledge and capacity to handle environmental affairs. Nevertheless, this case still sheds light on how financial policy innovation drives social changes. The key is to identify the connection between social issues and financial issues, and then to make a business case that creates pressures or incentives for financial institutions. This requires a market where social and environmental cost is appropriately priced and internalized to those who generate it. Ideally, financial policies should help shape such a market so that society can share values created by financial institutions.